Opening College Football Week 13 Odds, Spread and Early Predictions

• Week 13 of the college football season begins in earnest Thanksgiving night with #12 Ole Miss visiting #25 Mississippi State in the Egg Bowl
• The top matchup of the week has #4 Ohio State visiting #6 Michigan
• The full list of Week 13 opening lines and odds can be found below with predictions

One of the most storied rivalries in college football headlines Week 13.

Ohio State (10-1), currently ranked #4 but certain to move up on Tuesday, travels to Ann Arbor to meet #6 Michigan (10-1) at 12:00 pm ET Saturday in a Big Ten showdown. The opening line has the Buckeyes favored by 7.5 points.

The East Division championship will be on the line. Ohio State has an 8-0 record in conference play and Michigan is 7-1 but the Wolverines would hold the head-to-head tiebreaker with a win.

In the latest round of Bedlam, #13 Oklahoma (10-1) visits #9 Oklahoma State (10-1) at 7:30 pm ET, Saturday, in Stillwater. The Big 12 regular-season title is at stake as both teams are 7-1 in conference play. OK State opened as a three-point favorite.

Oklahoma State has clinched a berth in the Big 12 Championship Game and the Sooners could set up a rematch by beating the Cowboys; #11 Baylor is in third place and would gain a title game berth with a home win over Texas Tech and an Oklahoma loss.

One other gave involving ranked teams has #12 Mississippi visiting #25 Mississippi State at 7:30 pm ET Thursday in a Thanksgiving game in Starkville.

Here is a look at all the NCAAF Week 12 opening lines:

College Football Week 13 Opening Odds

Odds as on November 21st at DraftKings.

Big Game at The Big House

Ohio State blasted #7 Michigan State 56-7 on Saturday in Columbus as C.J. Stroud threw for six touchdowns and nearly 400 yards in the first half.

C.J. Stroud had a ridiculous first half performance: 29-31, 393 pass yards and 6 touchdowns 😳 pic.twitter.com/C1row39Vz6

— ESPN (@espn) November 20, 2021

Stroud finished 32 for 35 for 432 yards against the Spartans, who have allowed more passing yards than any team in the country. With Ohio State winning in a blowout, Stroud was removed from the game by coach Ryan Day late in the third quarter.

Michigan State’s Kenneth Walker III, the nation’s leading rusher, was held to 25 yards on six carries.

Michigan tuned up for the showdown in Ann Arbor by rolling to a 59-18 victory over Maryland on the road. Highlighting the rout was Mike Sainristil’s one-handed catch in the end zone for a second-quarter touchdown.

WHAT A CATCH BY MIKE SAINRISTIL 😳@UMichFootball is not letting up! 👀 pic.twitter.com/lFkOTb5gWO

— FOX College Football (@CFBONFOX) November 20, 2021

Hassan Haskins scored two TDs and Donovan Edwards had 10 catches for 170 yards and a touchdown for the Wolverines.

Ohio State has won eight straight games in the series and Michigan coach Jim Harbaugh has beaten the Buckeyes. While Ohio State is playing as well as any team in the country, this is a different Michigan team and should keep things close.

The Pick: Michigan +7.5 (-110)

Bedlam Could Set Up Bedlam II

Caleb Williams passed for a touchdown and ran for another as Oklahoma held off Iowa State 28-21 on Saturday while Jalen Redmond returned a fumble for a score.

CALEB WILLIAMS. TO. THE. HOUSE. pic.twitter.com/cD3V8eW4I2

— 𝕺𝖐𝖑𝖆𝖍𝖔𝖒𝖆 𝖛𝖘. 𝕿𝖍𝖊 𝖂𝖔𝖗𝖑𝖉 (@soonergridiron) November 20, 2021

Kennedy Brooks ran for 115 yards the Sooners.

Iowa State got the ball at its 14-yard line, trailing 28-21 with two minutes left. The Cyclones drove to the Oklahoma 21, but Pat Fields intercepted a pass by Brock Purdy with 15 seconds remaining.

Oklahoma State blanked Texas Tech 23-0 on the road, handing the Red Raiders their first shutout loss since 1997. It was the Cowboys’ first shutout on the road since 1985.

The Cowboys have allowed only one offensive touchdown over their past four games. Oklahoma held Texas Tech to 108 total yards, including a 25-yard pass on the final drive.

No fly zone 🚫#LetsRide I @TheJBnard pic.twitter.com/CqMzVp4ZyA

— OSU Cowboy Football (@CowboyFB) November 21, 2021

Spencer Sanders threw a touchdown and ran for another score and Tanner Brown kicked three field goals for Oklahoma State.

Oklahoma has beaten Oklahoma State six times in a row and in 16 of the last 18 games. However, look for the Cowboys defense to give Williams fits in this one.

The Pick: Oklahoma State -3 (-110)

Alabama Overvalued?

Alabama has proven it can cover just about any spread during the Nick Saban ERA, so being 19.5-point road favorites over archrival Auburn doesn’t seem like a big deal.

However, the Crimson Tide has not come close to covering in its last two SEC games. They beat LSU 20-14 as 29.5-point favorites Nov. 6 and Arkansas 42-35 as 20.5-point choices Saturday. Both were in Tuscaloosa.

Even though Auburn has lost three games in a row, this number seems high considering Alabama’s recent struggles.