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Week 10 College Football Picks Against the Spread

Ryan Bolta

by Ryan Bolta in College Football

Updated Jan 6, 2023 · 7:24 AM PST

Mario Cristobal
Mario Cristobal's Ducks return to the field for their abbreviated 2020 schedule this year. (Photo by Brian Rothmuller/Icon Sportswire)
  • Week 10 of the 2020 college football season features a slate of intriguing games on Saturday, November 7th
  • The Pac-12 becomes the final FBS conference to begin play this weekend with six conference games
  • See the odds and the best picks against the spread for your Week 10 card below

PAC-12 football is here, and there’s no better time to take advantage of the slate.

It’s easy for oddsmakers to get things right when they’ve had time to watch the teams and pour over the analytics. That’s why it’s awesome to try and get the jump and make some money right out of the gate.

Here are three picks from the opening weekend of PAC-12 action that you should consider betting.

Stanford vs #12 Oregon Week 10 Odds

Team Spread Moneyline Total
Stanford +10.5 (-115) +285 N/A
Oregon -10.5 (-107) -385 N/A

All odds taken Nov. 4th at DraftKings

Pick #1: Oregon Will Fail to Cover 10.5 Against Stanford

The Oregon Ducks are a good football team. The conference title odds tell you that. Fading them in their first game of the season isn’t meant to suggest they can’t have a competitive season.

It is however a strong belief that things are going to take time to come together in Eugene. The case can be made the Ducks lost more talent from last season than any other program in college football outside of the LSU Tigers.

The most obvious omission from the roster is quarterback Justin Herbert who is now plying his trade for the Los Angeles Chargers. Seeing the success Herbert has had at the next level goes to show he’ll be a tough one to replace.

Tyler Shough has potential to be a great college quarterback but it will take time. Left Tackle Penei Sewell will likely be a top five selection in the 2021 NFL draft and he opted out of the season to prepare for that next step.

Joining him in opting out were defensive backs Thomas Graham, Jevon Holland and Brady Breeze. The Ducks recruit well and have talent to fill in, but they may not be as talented and definitely won’t be as capable right out of the gate. Take Stanford to cover the number while Oregon works in the new talent.

The Pick: Stanford +10.5 (-114)

Colorado vs UCLA Week 10 Odds

Team Spread Moneyline Total
UCLA -6.5 (-121) -245 O 55.5 (-112)
Colorado +6.5 (+100) +195 U 55.5 (-109)

Pick #2: Take Colorado +6.5 at Home vs UCLA

There are a few rules in play with the decision to take Colorado as a home underdog against UCLA. First and foremost, it’s never a bad time to bet against Chip Kelly.

It’s his third season opener as the head of the Bruins program and he’s never started the season 1-0. More seriously though, giving up almost a touchdown requires an amount of faith in a defense that quite frankly just doesn’t deserve it.

UCLA ranked 113th in total defense last year. They bring back 10 of their top 13 tacklers but it’s tough to know it’s that’s good news or bad when looking at their numbers on that side of the ball.

Colorado on the other hand has some promise heading into this season. Karl Dorrell is the new head coach and opens his tenure against his former team. Dorrell went 35-27 at UCLA from 2003-2007. He’ll be working with a senior quarterback in Sam Noyer who will finally be handed the reigns are playing pieces of three seasons.

Noyer is a dual-threat who is 6’4 and 200 pounds. While he may not have the skill to wow scouts at the next level, he certainly appears to possess attributes that could cause the Bruins fits in this one. Bet on the Buffaloes to keep this one tight and consider the +100 price tag a cherry on top of the sundae.

The Pick: Colorado +10.5 (+100)

Arizona State vs #20 USC Odds

Team Spread Moneyline Total
Arizona State +10.5 (-107) +300 O 58.5 (-110)
#20 USC -10.5 (-114) -400 U 58.5 (-110)

Pick #3: Sun Devils Cover Against the Trojans

Two good teams, two good quarterbacks. Let’s start with each teams most important offensive weapon. USC returns starter Kedon Slovis who compiled 3,502 passing yards and 30 touchdowns last season. His one issue was interceptions, as he threw 9 of them in total and must do a better job protecting the football.

On the opposite sideline Arizona State bring back Jayden Daniels who had 2,943 passing yards and a 17/2 touchdown to interception ratio last year. In addition to his ability to throw the ball, Daniels rushed for 355 yards and three more scores on the ground. This matchup pits potentially the two most skilled returning quarterbacks in the conference.

Both teams have weapons to put up points, so this should be a shootout right? Not so fast. This one is scheduled to kickoff at noon eastern which is 9:00 AM pacific time. The Trojans will be in the huddle around the same time they would usually by huddling around the breakfast buffet. It’s a season opener being played bright and early for these two teams. Expect the game to be sloppier than you might expect, which makes getting 10.5 with the Sun Devils an inviting proposition.

The Pick: Arizona State +10.5 (-107)

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