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College Football Week 2 Odds, Lines, Predictions and TV Schedule

Chris Amberley

by Chris Amberley in College Football

Updated Sep 9, 2021 · 5:25 AM PDT

Haasan Haskins touchdown run
Michigan running back Hassan Haskins runs for a touchdown against Western Michigan during an NCAA football game on Saturday, Sept. 4, 2021, in Ann Arbor, Mich. (AP Photo/Al Goldis)
  • Week 2 of the College Football season continues September 10th-11th
  • No. 3 Ohio State gained 10.3 yards per play in Week 1, which ranked second among FBS teams
  • All the odds can be found below along with some best bets for Week 2

The college football season rolls on as Week 2 games featuring Power 5 teams kick off Friday and Saturday around the country.

All of the nation’s top-10 programs are in action, but a handful of their games are off the board, which speaks to the lack of quality of their opponents.

No. 3 Ohio State is not one of those super elites facing a cupcake opponent, as they’re expected to have their hands full with No. 12 Oregon.

Check out all the Week 2 odds below, plus a few bets to target, starting with a potential shootout between the Ducks and Buckeyes.

College Football Week 2 Odds

Team Moneyline Spread Total Broadcast
Kansas +1500 +25 (-105) O 52 (-110) ESPN2
Coastal Carolina -3500 -25 (-115) U 52 (-110) Fri 7:30pm ET
Team Moneyline Spread Total Broadcast
Illinois +300 +10 (-110) O 55 (-110) ACC Network
Virginia -400 -10 (-110) U 55 (-110) Sat 11am ET
Team Moneyline Spread Total Broadcast
Oregon +475 +14.5 (-115) O 63.5 (-115) FOX
Ohio State -675 -14.5 (-105) U 63.5 (-105) Sat 12pm ET
Team Moneyline Spread Total Broadcast
South Carolina -125 -1.5 (-110) O 58 (-105) ESPN2
East Carolina +105 +1.5 (-110) U 58 (-115) Sat 12pm ET
Team Moneyline Spread Total Broadcast
Pittsburgh -180 -3.5 (-110) O 57 (-110) ESPN
Tennessee +155 +3.5 (-110) U 57 (-110) Sat 12pm ET
Team Moneyline Spread Total Broadcast
Miami OH +750 +20 (-110) O 53.5 (-115) ESPNU
Minnesota -1250 -20 (-110) U 53.5 (-105) Sat 12pm ET
Team Moneyline Spread Total Broadcast
 Tulsa +385 +13 (-110) O 51.5 (-110) FS1
Oklahoma State -525 -13 (-110) U 51.5 (-110) Sat 12pm ET
Team Moneyline Spread Total Broadcast
Florida -4500 -28 (-105) O 58 (-105) ABC
South Florida +1800 +28 (-115) U 58 (-115) Sat 1pm ET
Team Moneyline Spread Total Broadcast
Middle Tennessee +750 +20.5 (-115) O 54 (-115) ACC Network
Virginia Tech -1250 -20.5 (-105) U 54 (-105) Sat 2pm ET
Team Moneyline Spread Total Broadcast
Toledo +600 +16.5 (-110) O 54.5 (-115) Peacock
Notre Dame -900 -16.5 (-110) U 54.5 (-105) Sat 2:30pm ET
Team Moneyline Spread Total Broadcast
Purdue OFF -33.5 (-110) O 58 (-110) ABC
 UConn OFF +33.5 (-110) U 58 (-110) Sat 3pm ET
Team Moneyline Spread Total Broadcast
Ball State +950 +23 (-115) O 57 (-110) CBSSN
Penn State -1750 -23 (-105) U 57 (-110) Sat 3:30pm ET
Team Moneyline Spread Total Broadcast
Boston College OFF -37 (-120) O 60 (-110) FloSports
Massachusetts OFF +37 (+100) U 60 (-110) Sat 3:30pm ET
Team Moneyline Spread Total Broadcast
UAB +1400 +24.5 (-110) O 45.5 (-115) ESPN2
Georgia -3300 -24.5 (-110) U 45.5 (-105) Sat 3:30pm ET
Team Moneyline Spread Total Broadcast
California +340 +13.5 (-110) O 48 (-110) ESPNU
TCU -450 -13.5 (-110) U 48 (-110) Sat 3:30pm ET
Team Moneyline Spread Total Broadcast
Buffalo +400 +13.5 (-115) O 54.5 (-110) BIG TEN Network
Nebraska -550 -13.5 (-105) U 54.5 (-110) Sat 3:30pm ET
Team Moneyline Spread Total Broadcast
Texas A&M -850 -17 (-115) O 51 (-105) FOX
Colorado +575 +17 (-105) U 51 (-115) Sat 3:30pm ET
Team Moneyline Spread Total Broadcast
Iowa +165 +4.5 (-110) O 46 (-110) ABC
Iowa State -195 -4.5 (-110) U 46 (-110) Sat 4:30pm ET
Team Moneyline Spread Total Broadcast
Texas -255 -6.5 (-115) O 57 (+100) ESPN
Arkansas +205 +6.5 (-105) U 57 (-120) Sat 7pm ET
Team Moneyline Spread Total Broadcast
Eastern Michigan +1300 +26 (-105) O 52 (-110) FS1
Wisconsin -3000 -26 (-115) U 52 (-110) Sat 7pm ET
Team Moneyline Spread Total Broadcast
Appalachian State +250 +9 (-115) O 55 (-110) ESPNU
Miami FL -320 -9 (-105) U 55 (-110) Sat 7pm ET
Team Moneyline Spread Total Broadcast
North Carolina State -130 -2.5 (-110) O 55.5 (-110) ESPN2
Mississippi State +110 +2.5 (-110) U 55.5 (-110) Sat 7pm ET
Team Moneyline Spread Total Broadcast
Missouri +175 +5 (-110) O 56.5 (-110) SEC Network
Kentucky -210 -5 (-110) U 56.5 (-110) Sat 7:30pm ET
Team Moneyline Spread Total Broadcast
Georgia State +1200 +22.5 (-110) O 66 (-110) ESPN3
North Carolina -2500 -22.5 (-110) U 66 (-110) Sat 7:30pm ET
Team Moneyline Spread Total Broadcast
Washington +220 +6.5 (+105) O 48.5 (-110) ABC
Michigan -275 -6.5 (-125) U 48.5 (-110) Sat 8pm ET
Team Moneyline Spread Total Broadcast
Vanderbilt +220 +7 (-110) O 51 (-110) CBSSN
Colorado State -275 -7 (-110) U 51 (-110) Sat 10pm ET
Team Moneyline Spread Total Broadcast
San Diego State -125 -1.5 (-110) O 47 (-110) PAC-12 Network
 Arizona +105 +1.5 (-110) U 47 (-110) Sat 10pm ET
Team Moneyline Spread Total Broadcast
 Utah -280 -7 (-110) O 49 (-110) ESPN
BYU +225 +7 (-110) U 49 (-110) Sat 10:15pm ET
Team Moneyline Spread Total Broadcast
Stanford +600 +17 (-110) O 51.5 (-120) FOX
USC -900 -17 (-110) U 51.5 (+100) Sat 10:30pm ET
Team Moneyline Spread Total Broadcast
UNLV OFF +33.5 (-110) O 53 (-110) ESPN2
Arizona State OFF -33.5 (-110) U 53 (-110) Sat 10:30pm ET
Team Moneyline Spread Total Broadcast
Hawaii +340 +11 (-105) O 64 (-110) FS1
 Oregon State -450 -11 (-115) U 64 (-110) Sat 11pm ET

Odds as of September 7th at DraftKings

Oregon vs Ohio State

Ohio State is a 14.5-point favorite, in a game that features a total of 63.5. The over/under is up 5 points since it opened, and it’s not hard to see why.

The Buckeyes offense put on a show in Week 1, lighting up Minnesota for 45 points, 35 of which came in the second half. C.J. Stroud threw for 294 yards and four touchdowns in his first career start, while the team averaged 10.3 yards per play, the second best mark of any FBS program.

Ohio State is the number one ranked offense per SP+, and now faces an Oregon program that could be without a couple key starters. Projected top-five pick Kayvon Thibodeaux is questionable, after suffering an ankle injury in the Ducks’ season opener, while linebacker Dru Mathis had already been ruled out with a leg issue. Oregon allowed Fresno State, ranked 39th offensively per SP+, to put up 24 points and 373 yards on them in Eugene last week, and should struggle to handle the Buckeyes’ firepower.

As good as Ohio State’s offense looked, their defense looked equally as bad. The Buckeyes surrendered 31 points and 408 total yards to Minnesota last week, while the Ducks offense is loaded with experience. Nine starters are back from last season, including dual threat QB Anthony Brown, who’s in his sixth collegiate season.

Pick: Over 63.5 (-115)

Washington vs Michigan

Our next target is Michigan, who’ll host Washington as 6.5-point favorites. The Wolverines got off to a strong start last week, blowing out Western Michigan by 33, easily covering the 17-point spread. Michigan started slow, but reeled off 40 straight points to cruise to victory.

Jim Harbaugh’s crew averaged 9.2 yards per play, amassing 335 rushing yards, while limiting WMU to 4.6 yards per play. Michigan did lose star receiver Ronnie Bell for the season, but this team wants to pound the ball as much as possible. The Wolverines carried the ball 40 times, and produced three rushing TD over 22 yards.

Washington on the other hand, suffered the worst loss of any Power 5 team in Week 1, losing to FCS program Montana. The Huskies managed only 291 yards, and freshman Dylan Morris was picked off three times by the Grizzlies defense.

Morris averaged just 4.9 yards per attempt, while the run game also struggled putting up 2.4 yards per carry.

Pick: Michigan -6.5 (-125)

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