Opening College Football Week 12 Odds, Spreads and Early Predictions

• Ranked #17 in the nation, Tulane hosts SMU on Thursday night in the first game involving a ranked team during Week 12 of the college football season
• Top games Saturday include #8 USC vs #12 UCLA and #13 Utah vs #6 Oregon
• A look at all the Week 12 opening odds can be found below with early predictions

The first game involving a ranked team during Week 12 of the college football season is Thursday when #17 Tulane hosts SMU in the American Athletic Conference.

Tulane (8-2) had its five-game win-streak end Saturday with a 31-24 loss to visiting UCF but is favored by 2.5 points against the Mustangs. SMU (6-4) won at South Florida 41-23 to run its winning streak to three games.

Four games involving ranked teams are on the schedule for Saturday: #21 Illinois (7-3) vs #3 Michigan (10-0) in the Big Ten, #1 Georgia (10-0) vs #24 Kentucky (6-4) in the SEC and #8 USC (9-1) vs #12 UCLA (8-2) and #13 Utah (8-2) vs #6 Oregon (8-2) in the Pac-12.

The college football odds will be updated throughout the week

College Football Week 12 Opening Odds

Odds as of November 13th at DraftKings Sportsbook. Claim a DraftKings promo code. 

Texas A&M, despite being one of the season’s biggest disappointments, is the biggest favorite of the week at 34.5 points over Massachusetts. The smallest spread is the two points that TCU are favored by over Baylor.

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USC vs UCLA Opening Odds & Prediction

USC can wrap up at least a share of the Pac-12 regular season title when it visits crosstown rival UCLA at the Rose Bowl in Pasadena, Calif. The Bruins need a win to keep any hope alive of reaching the conference championship game. USC opened as a 2.5-point favorite.

On Friday night, USC routed Colorado 55-17 at home for its third straight win. Caleb Williams passed for 268 yards and three touchdowns.

Williams accounted for five touchdowns in all as he also ran for two scores. Former Buffaloes wide receiver Braeden Rice had 70 yards receiving and one TD.

.@CalebCSW to @tahj_washington for the 61-yard touchdown! 💨

📺: @FS1
📱: https://t.co/u7u02qaID8#FightOn | #FYC13 pic.twitter.com/B4L2m29BgK

— USC Football ✌️ (@uscfb) November 12, 2022

UCLA was upset by Arizona 34-28 at home. The Bruins are just 2-2 in their last four games following a 6-0 start to the season.

Zach Charbonnet rushed for 181 yards and three touchdowns, but it wasn’t enough for UCLA.

It has been a while since this game carried so much importance. Look for Williams and the Trojans to rise to the occasion.

Pick: USC -2.5 (-110)