Bills vs Titans Odds, Lines, and Picks for Week 6 Monday Night Football
- The Buffalo Bills visit the Tennessee Titans on Monday night, seeking their fifth straight win
- Monday Betting Record: 0-0 ML; 2-3 ATS; 2-1 O/U; -0.315 units
- Check below for all the odds and trends for this MNF Week 6 clash
The only way to describe the Tennessee Titans’ 42-16 win over the Buffalo Bills last year was a whipping.
This year, the Bills enter the rematch as the bullies of the league — and quite possibly the best team in the NFL — as they visit the Titans on Monday Night Football.
Buffalo has laid waste to the competition en route to four straight wins, including last week’s all-business trip to KC, handing Patrick Mahomes his worst-ever defeat.
They enter this one as 5.5-point road favorites, but the Titans, behind the NFL’s top running back in Derrick Henry, could provide some resistance.
Kickoff goes at 8:15pm ET from Nissan Stadium in Music City.
Bills vs Titans Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Buffalo Bills | -5.5 (-110) | -260 | O 53 (-110) |
| Tennessee Titans | +5.5 (-110) | +210 | U 53 (-110) |
*Odds taken on Oct 17 from DraftKings.
The line opened at Bills -4.5, but has moved a full point since. The betting public is rolling with the Bills: 87% of the bets placed against the spread and on the moneyline are on Buffalo, while 76% have taken the under.
The weather is calling for clear skies and a pleasant 72 degrees on Monday night.
Bills Collectors
Perhaps the most surprising thing about these Bills is that their lone loss of the year came against the Pittsburgh Steelers, which has clearly been the outlier for both teams.
Since then, Buffalo has lit the league on fire, outscoring the competition 156-41 in four straight wins, pitching two shutouts.
Wow! Allen if flushed out of the pocket and finds a wide open Dawson Knox… his favorite TD target of late. #Bills take the 24-10 lead. pic.twitter.com/MmX8ju7dpN
— Bradley Gelber (@BradleyGelber) October 11, 2021
We know about their offense: Buffalo is averaging 34.4 points per game and their 172 total points tops the NFL. But their defense has also surrendered just 64 points all year, a 12.8 mark, which is the lowest in the league too.
Both side were on display in Week 5 in a supposed showdown of AFC powers, but turned into a 38-20 Bills’ thumping of the Chiefs.
Josh Allen did his usual thing, going 15-for-26 for 315 yards and three TD tosses, while leading the team in rushing with 59 yards and a score, all under mostly rainy conditions.
Gregory Rousseau | #TheU® pic.twitter.com/YW5GWNcRgM
— GO ‘CANES! (@83_87_89_91_01) October 11, 2021
They also turned Mahomes human — something only the Tampa Bay Buccaneers had been able to lay claim to previously — limiting Mahomes to 5.0 yards per attempt on 54 throws, easily the lowest of any of his 59 career starts. Buffalo also picked him off twice and recovered a Mahomes fumble late.
Down With the King (Henry)
It’s hard to peg down just what the Tennessee Titans are so far this season.
Part of it is their on-field production. They’ve laid a dud against the Cardinals in Week 1 (who are currently the only unbeaten team in the NFL), before winning in comeback fashion in the not-so-comfy confines of Seattle. Tennessee happens to be the only team the Jets have beaten, but they pummeled the hapless Jags last time out.
Best plays from @KingHenry_2's 3-TD game vs. Seahawks 👑
📺: More coverage on @nflnetwork pic.twitter.com/bWveTnLd5M
— Tennessee Titans (@Titans) September 21, 2021
Part of the inconsistency is injuries. There are currently 14 Titans on injured reserve, and key pieces like receivers AJ Brown and Julio Jones have shared very little field time together through five weeks.
The one constant is Derrick Henry, who they have fed mercilessly to start the year, and more often than not, he’s come through.
Henry leads the NFL in rushing: his 142 carries is nearly 50 more totes than the next closest competitor, and his 640 yards are more than 100 yards clear of second place. In fact, only two other players have crossed 390 yards rushing on the season.
#Titans Top 5 Plays vs. Bills | @nflthrowback #TBT pic.twitter.com/pWfnea5bMS
— Tennessee Titans (@Titans) October 14, 2021
He’ll get a stiff test against the Bills, who are surrendering just 78.4 yards on the ground, third best in the NFL. Before you think of changing the scheme to let Ryan Tannehill spin, Buffalo gives up just 173.4 yards through the air, the second-best mark in football.
What’s the Best Bet?
Another real test will be to see how the Titans’ defense — which ranks 21st in total yards — will try and handle Allen and this offense. After that 42-16 drubbing last year, the Bills lost a second straight, and they have been rolling since, reeling off 13 wins against just two losses in their last 15 regular season games.
It’s clearly a game the team has marked on its calendar, much like the KC game, and in primetime to boot.
Henry keeps it close, but Buffalo shows it’s the cream of the crop Monday night, and they serve up back-to-back revenge platters.
The Pick: Bills-5.5 (1.5 unit to win 1.86 units)
Having worked in and around sports since 1997, Eric is truly a knowledgeable expert. The two-time journalism grad specializes in all things NBA and NFL. From TSN.ca to CTV's Olympic Broadcast Consortium, Eric's work has appeared in local and national publications alike.
