Upcoming Match-ups

Chiefs vs Titans Odds, Picks, and Predictions

John Perrotto

by John Perrotto in NFL Football

Updated Oct 23, 2021 · 6:10 AM PDT

Derrick Henry running on sidelines with helmet off
Tennessee Titans running back Derrick Henry leaves the field after the Titans beat the Buffalo Bills 34-31 in an NFL football game Monday, Oct. 18, 2021, in Nashville, Tenn. (AP Photo/Wade Payne)
  • The Chiefs are a 4.5-point road favorites over the Titans on Sunday
  • Betting Record: 1-1 ML; 3-1 ATS; 1-0 O/U; +2.8 units
  • The odds and lines can be found below with a prediction

Two AFC heavyweights in recent years meet when the Kansas City Chiefs visit the Tennessee Titans at 1pm ET Sunday at Nissan Stadium in Nashville.

The Chiefs (3-3) have won two of their last three games both straight-up and against the spread. The AFC South-leading Titans (4-2) are coming off back-to-back wins.

In a game that will be televised to part of the country by CBS, the Chiefs are favored by 4.5 points.

Chiefs vs Titans Odds

Team Moneyline Spread Total
Kansas City Chiefs -210 -4.5 (-110) Over 57.5 (-105)
Tennessee Titans +175 +4.5 (-110) Under 57.5 (-115)

Odds as of October 23rd at DraftKings.

The Chiefs opened as 4.5-point picks and the spread had held steady all week. Kansas City, though, has been getting 69% of the action.

It is expected to be a warm and windy day in Nashville with a high temperature of 82 degrees and winds from the south at 10-15 mph with gusts up to 25 mph.

Coming off Wins

The Chiefs notched a 31-13 road victory over the Washington Football Team last weekend. On Monday Night Football, the Titans beat the Buffalo Bills 34-31 at home.

Patrick Mahomes threw for 397 yards and engineered three second-half touchdown drives to spark the Chiefs. That helped overcome his two interceptions.

The Titans were led by Derrick Henry, who rushed for 143 yards and three touchdowns. The last score came with 3:05 left and put Tennessee ahead for good.

The teams are playing for the first time since the 2019 AFC Championship Game, which the Chiefs won 35-24. That ended the Titans’ four-game winning streak in the series.

Patrick’s Picks Mounting

Mahomes has thrown eight interceptions in six games this season. The only NFL quarterback who has more picks is New York Jets rookie Zach Wilson with nine.

Mahomes threw just six interceptions last season and five in 2019.

On the plus side, Mahomes is third in the league with 1,887 passing yards and his 18 touchdown passes top the NFL. He is completing a career-best 69% of his passes and has a 103.1 quarterback rating.

Mahomes will need to be wary of safety Kevin Byard, who is tied for third in the league with three INTs. Byard’s 21 interceptions since 2017 are the second-most in the NFL behind the 23 of the Miami Dolphins’ Xavien Howard.

No Halting Henry

Henry is the NFL’s runaway rushing leader with 783 yards and 10 touchdowns on 162 carries. He is third player in league history to have at least 750 rushing yards and 10 TD runs in the first six games of a season.

Consistency is one of Henry’s hallmarks. He has rushed for at least 100 yards in five straight games.

The Chiefs would seem to be a good matchup for Henry. Kansas City is allowing 133.2 yards a game, which ranks 27th among the 32 NFL teams.

Henry also has the opportunity to atone for a so-so performance in the ’19 AFC title game when he was held to 69 yards on19 attempts.

Injury Update

The Chiefs will be without running back Michael Burton (pectoral), tight end Joe Fortson (Achilles) and linebacker Anthony Hitchens (triceps). Wide receiver Tyreek Hill (quadricep), defensive end Chris Jones (wrist), guard Joe Thuney (hand) and cornerback CB Charvarius Ward (quadricep) are all questionable.

Titans offensive tackle Taylor Lewan, who suffered a concussion Monday night, has been ruled out along with linebacker Monty Rice (groin) and wide receiver Chester Rogers (groin). Listed as questionable are linebacker Bud Dupree (knee), safety Amani Hooker (groin), wide receivers Julio Jones (hamstring) and running back Jeremy McNichols (ankle).

Big Red’s Achilles’ Heel

The Chiefs’ Andy Reed is the sixth-winningest coach in NFL history with 226 victories. However, he is just 2-8 against the Titans.

While the Titans won’t necessarily win this matchup, they look like an attractive play with the points against the turnover-prone Chiefs, especially on what could be a blustery day along the shores of the Cumberland River.

The Pick: Titans (+4.5)

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