NFL Picks Against the Spread for Week 4: Why You Should Bet On The Giants

• NFL Week 4 continues on Sunday, September 28
• In my Week 4 NFL picks against the spread, I am targeting two underdogs and one favorite
• Keep reading for my best NFL ATS picks for Week 4

NFL Week 3 was an all-timer. There were huge upsets, big comebacks, last-second victories, and more blocked kicks than I could count. We can only hope to get similar outcomes this Sunday.

Looking ahead, there are some intriguing matchups in Week 4, including an Ireland game and a Monday Night Football doubleheader. We also have the largest spread we have seen this season in the Bills (-15.5) and Saints.

Let’s dive into all the NFL Week 4 spreads and my favorite NFL picks against the spread for Sunday, September 28.

NFL Week 4 Picks Against the Spread

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NFL ATS Pick #1: Buccaneers +3.5 vs Eagles

The Eagles are coming off an emotional comeback win in the final seconds, thanks to a blocked field goal that was returned for a touchdown. That is a situation where I like betting against that team the following week. Philadelphia has also struggled with Tampa Bay over the last few seasons.

They are just 1-6 straight up and 2-5 against the spread in their last seven games against the Buccaneers.

Tampa Bay is at home, and Baker Mayfield loves the underdog role. He is 15-6 against the spread as an underdog with the Buccaneers.

The Eagles have won nine games in a row, but I trust Baker and this Bucs team to keep this game close at home against Philadelphia. I love getting Tampa Bay over a field goal.

• Week 4 NFL Pick: Buccaneers +3.5 (-110)

NFL ATS Pick #2: Giants +6.5 vs Chargers

The Russell Wilson era in New York is finally over, and the Giants will be turning to Jaxson Dart. The Chargers present a tough test on defense, but they have no film on Dart in the NFL, and the new quarterback should provide a spark to this team.

This is also a weird spot for the Chargers. They are 3-0, winning three straight division games, and now they have to travel to the East Coast and play in the 1:00 window. Betting against West Coast teams playing on the East Coast is not as profitable as it used to be, but I am still expecting a letdown spot for the Chargers after three AFC West matchups.

The Giants gave the game to the Chiefs on Sunday Night Football, and despite the 0-3 start, they have been strong defensively and have been able to run the football.

They are at home, and I know it is gross, but 6.5 points is just too much for me to lay with the Chargers.

• Week 4 NFL Pick: Giants +6.5 (-110)

NFL ATS Pick #3: Ravens -2.5 vs Chiefs

NFL Week 4 features a huge matchup between unexpected 1-2 teams. Either the Ravens or the Chiefs will drop to 1-3 to start the season, and I am putting my money on that team being the Chiefs.

Kansas City got the win against the Giants on Sunday Night Football, but they did everything they could to give that game away. The Ravens have had two close losses to good teams, and I am expecting them to come back in a big way against a struggling Chiefs team.

Lamar Jackson is 21-4 straight up after a loss in his career, and he is 34-16 straight up on the road with the Ravens.

Betting against Patrick Mahomes as an underdog is scary, but this is not the same Chiefs team we have gotten used to. Their offense is not in sync, and their defense has been struggling. The Ravens, despite the two losses, have looked explosive and should leave Arrowhead with a win (and a cover).

• Week 4 NFL Pick: Ravens -2.5 (-115)