San Francisco 49ers vs Seattle Seahawks Odds, Lines, Predictions, and Picks

• The San Francisco 49ers (6-5) visit the Seattle Seahawks (3-8) in a Week 13 NFC West clash
• 2021 Record: 7-4, +1.42 units
• See the updated odds ahead of Sunday’s 4:25 pm EST kickoff from Lumen Field

Don’t look now, but Jimmy Garoppolo has led the San Francisco 49ers back into the playoff picture.

The 49ers have won three in a row and four of five. After entering their bye at 2-3 and looking up at the NFC West, their red-hot play leaves San Fran a game out of the top Wild Card spot.

For the Seahawks, it’s unfamiliar territory. They’re 3-8 and second-last in the NFC; unheard of for Russell Wilson and Pete Carroll.

Seattle has a chance to score a rare win at home on Sunday against their NFC West rivals. Kickoff is at 4:25 pm EST from Lumen Field.

49ers vs Seahawks Odds

Odds as of December 4th at DraftKings

Seattle enters as a home underdog, which aligns with their season-long struggles. They’re 1-4 outright at home, and 0-3 against the spread over their last three overall.

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NFL Public Money is heavily favoring the 49ers, which is a direct result of Seattle’s disappointing Monday night showing. San Fran is 4-1 over their last five ATS.

49ers vs Seahawks Injury Report

There are a couple of key players on Week 13’s injury list for San Fran.

Deebo Samuel already being ruled out is a huge loss. Samuel is two catches away from career-highs across the board and has been one of the most dangerous players in the league this year.

#49ers LB Dre Greenlaw, who missed time on Sunday with a groin injury, is a long-shot to play this week, source said. He hasn’t been ruled out, but he won’t practice today & will be monitored through the week. Greenlaw was activated off IR last week following core muscle surgery.

— Ian Rapoport (@RapSheet) December 1, 2021

Kyle Shanahan said earlier this week that Fred Warner will not play, although he was slapped with a doubtful tag. The 49ers will be thin at linebacker with Dre Greenlaw out and Marcell Harris likely following suit.

Week 13 Injury Report

Seattle’s running backs are banged up, but it’s not like they’ve been terribly effective lately. Nagging injuries consistently find Penny, and Collins has averaged just 3.21 YPC over his last five games and 2.94 his last two.

Seahawks vs 49ers Head-to-Head

These two have already squared off once this year under different circumstances.

While he only threw for 149 yards and a pair of TDs, Wilson was an MVP candidate. The 49ers meanwhile, lost Garoppolo to injury shortly after an opening drive touchdown. That lead to Trey Lance’s first extended NFL action

49ers vs Seahawks: Last Five Games

Lance played well, all things considered, throwing for 157 yards, two TDs, and picking up 41 yards on the ground. It wasn’t good enough to get San Fran the win, however.

The third overall pick would get one more start before Garoppolo returned. While the results have varied based on the game plan, it’s proven that Jimmy G is the best man for the job right now.

Jimmy Garoppolo’s Slow Start in 2021

It was not an easy few months for Jimmy G.

Rumors persisted that he was on the outs in San Fran before the draft. Then Lance entered the picture and, while it seemed to cement Garoppolo’s status for 2021, there was understandable buzz around the rookie.

The NFL's highest rated QBs since the calendar flipped to November: Mac Jones and Jimmy Garoppolo pic.twitter.com/ZwCPq9aDwd

— Ben Volin (@BenVolin) November 29, 2021

Before getting hurt in Week 4, Garoppolo’s numbers were fine, but not flashy. After posting a pedestrian line in his Week 7 return against Indy however, it’s been mostly smooth sailing for the QB1.

Jimmy Garoppolo: Weeks 1-7 vs Weeks 8-12

Garoppolo’s numbers have been better over this stretch, but it’s also coincided with a heavy emphasis on running the ball.

Before their bye week, San Francisco topped 145 total rushing yards just once. That was in Week 5 when Garoppolo was injured. Since his return, they’ve crossed that number in all four of their wins. They’ve gone over 155 in each of their last three.

Jimmy Garoppolo's career passer rating on the 49ers when Deebo Samuel plays: 100.4.

Jimmy Garoppolo's career passer rating on the 49ers when Deebo Samuel does not play: 93.7.

— Grant Cohn (@grantcohn) December 3, 2021

That’s bad news for the Seahawks, who were trampled by Washington on Monday night. The 152 yards they allowed were the second-most they’ve allowed this season, and they’re 1-5 when they allow an opponent to run for 115 or more.

49ers vs Seahawks Prediction

Based on the last four weeks, it seems pretty obvious what we’ll see out of San Francisco on Sunday. They’re going to run the ball. And run it again.

Losing their most dynamic weapon in Deebo Samuel hurts. But there’s still Brandon Aiyuk and George Kittle, and a deep running back room.

The losses at the linebacker level hurt the 49ers, but that’s not where the Seahawks will threaten them. The Niners have held the ball for an average of 38:10 over their last three games. Seattle is last in that category at 19:36.

Expect San Fran to control the clock, and the scoring opportunities, in a low-scoring affair.

The Pick: Under 46.0 (-110); 1 Unit