NFL Week 10 Picks Straight Up – Predicted Upsets and Underdogs Showing Value

• Injuries under center diminish Bills’, Rams’ value as home favorites
• Can Seahawks maintain winning ways in date with Bucs in Munich?
• Read on for all the odds and trends behind our picks for this week’s NFL upsets

Quarterback injuries play a big role in our NFL Week 10 predicted upsets.

The uncertain status of both Josh Allen and Matthew Stafford provides opportunities for sports bettors backing the Minnesota Vikings and Arizona Cardinals, while it is far from clear that travelling to Germany will enable the Tampa Bay Buccaneers to escape their offensive woes in their date with the surging Seattle Seahawks.

NFL Week 10 Upset Picks

Odds as of November 12 at Caesars Sportsbook.

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Josh Allen Injury a Blow to Bills

The uncertain status of Josh Allen has already taken its toll on the Buffalo Bills at the sportsbooks.

Pegged as 7.5-point favorites in the NFL Week 10 opening odds, the Bills have since rapidly faded to just 3-point chalk, and with good reason. Allen has been key to Buffalo’s 6-2 start while trending towards a career year with 2,403 passing yards and 19 touchdown passes through eight outings.

Bills fans better pray Josh Allen’s alright pic.twitter.com/Ul4m3lQbMK

— Barstool Sportsbook (@BSSportsbook) November 11, 2022

Allen has also anchored the Bills ground game, piling up a team-high 392 rushing yards and four scoring runs. With the Bills likely to lean more on the run should Allen be unavailable, they will face a stiff challenge from a Vikings rush defense that has held opposing rushers to under 80 yards, and out of the end zone, in each of their past four games.

Further complicating matters for the Bills are injuries to their secondary that landed cornerbacks Cam Lewis and Dane Jackson on the injury list, and left Kaiir Elam listed as doubtful. That could open the door to a big day for Minnesota pivot Kirk Cousins, who has tossed for 10 scores against just three picks during the Vikings’ current 6-0 run.

Cardinals Offer Value Against Injury-Ravaged Rams

Super Bowl champions just nine months ago, the Los Angeles Rams look to overcome a miserable first half to their season as they get set for Sunday’s date with Arizona as 3-point favorites in the NFL odds.

Generating offense has been a struggle since early in the game as the team dealt with injuries, particularly on their offensive line. Currently ranked 29th in the NFL with just 16.4 points scored per game, the Rams have seen things go from bad to worse after quarterback Matthew Stafford suffered a concussion in last week’s 16-13 loss in Tampa Bay.

From NFL Now: #Rams QB Matthew Stafford is in the NFL's concussion protocol, putting his status in doubt for Sunday. pic.twitter.com/vQO1xS0r6y

— Ian Rapoport (@RapSheet) November 10, 2022

Stafford remains listed as questionable, but if he is unable to go, the stage is set for John Wolford to make his first start under center since Week 17 of the 2020 season, when he led the Rams to an 18-7 win over these same Arizona Cardinals.

But in addition to wondering where the offense will come from, the Rams face a tall order in duplicating the defensive effort they displayed in Wolford’s lone previous start. One positive for the Rams is the current rash of injuries impacting the Cardinals, including a hamstring injury that quarterback Kyler Murray has been playing through. However, should Murray be good to go, the Cardinals maintain considerable value as a 3-point underdogs against a Rams squad that has averaged just 14 points per game during a 1-4 slide.

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Can Battered and Bruised Seahawks Outpace Bucs in Germany?

The NFL’s European experiment continues on Sunday in Munich, with a game best described as a clash between this season’s most overrated and underrated teams. Once again the Tampa Bay Buccaneers have emerged as betting chalk, crossing the Atlantic perched as 2.5-point favorites over the Seattle Seahawks despite struggling to score and failing to produce an against the spread win during a 2-5 run.

With just four scoring passes over the past five games, and none before halftime over that stretch, quarterback Tom Brady has struggled to light up the scoreboard despite trailing only Patrick Mahomes in total passing yards this season. And with the receiving corps still dealing with injuries, Brady could have limited downfield targets at his disposal. Russell Gage is confirmed out, while Cameron Brate, Mike Evans, and Julio Jones are all nursing ailments.

Meanwhile, the Seahawks are still searching for respect at the sportsbooks after extending their current win streak to four games with last week’s 31-21 win over Arizona. Now perched atop the NFC West standings, the Seahawks have averaged 31.6 points per game over their past three outings. Rookie rusher Kenneth Walker II has been a standout, marching for seven scores over the past five games.

However, the one concern that tempers enthusiasm surrounding Seattle are injuries to receiver Marquise Goodwin, who is listed as questionable, as well as DK Metcalf, Penny Hart, Tyler Lockett, and tight end Noah Fant, all of whom made the injury report this week.