Upcoming Match-ups

NFL Week 7 Odds – Opening Lines and Spreads for All Games

John Perrotto

by John Perrotto in NFL Football

Updated Oct 17, 2021 · 6:12 PM PDT

Kyler Murray slings a pass
Arizona Cardinals quarterback Kyler Murray (1) throws a 9-yard touchdown pass to wide receiver DeAndre Hopkins (10) during the second half of an NFL football game against the Cleveland Browns, Sunday, Oct. 17, 2021, in Cleveland. (AP Photo/David Richard)
  • Week 7 of the NFL season opens Thursday night with the Browns hosting the Broncos
  • The Cardinals are the biggest favorites as 16.5-point home choices over the Texans
  • All the Week 7 opening lines and spreads can be found below

Week 7 of the NFL season begins Thursday night when the Cleveland Browns host the Denver Broncos.

The Browns have opened as 5.5-point favorites despite getting smoked at home by the Arizona Cardinals 37-14 on Sunday. Back-to-back losses have dropped Cleveland’s record to 3-3. The Broncos (3-3) have lost three in a row since beginning the season on a three-game winning streak and fell 34-24 to the Raiders on Sunday in Denver.

Sunday Night Football features the Indianapolis Colts visiting the San Francisco 49ers. San Francisco is a 5.5-point favorite.

The Seattle Seahawks host the New Orleans Saints on Monday Night Football and are 3-point underdogs at Lumen Field.

Here is a look at all the NFL Week 7 lines:

NFL Week 7 Opening Odds

Team Moneyline Spread Over/Under
Denver Broncos +194 +5.5 (-110) Over 43.5 (-110)
Cleveland Browns -235 -5.5 (-110) Under 43.5 (-110)
Team Moneyline Spread Over/Under
Cincinnati Bengals +225 +6.5 (-105) Over 48.5 (-110)
Baltimore Ravens -275 -6.5 (-115) Under 48.5 (-110)
Team Moneyline Spread Over/Under
Carolina Panthers -154 -3 (-106) Over 44.5 (-110)
New York Giants +130 +3 (-114) Under 44.5 (-110)
Team Moneyline Spread Over/Under
Washington Football Team +340 +8.5 (-105) Over 49.5 (-110)
Green Bay Packers -430 -8.5 (-115) Under 49.5 (-110)
Team Moneyline Spread Over/Under
Kansas City Chiefs -215 -4.5 (-114) Over 56.5 (-110)
Tennessee Titans +180 +4.5 (-106) Under 56.5 (-110)
Team Moneyline Spread Over/Under
Atlanta Falcons -120 -1.5 (-110) Over 47.5 (-110)
Miami Dolphins +102 +1.5 (-110) Under 47.5 (-110)
Team Moneyline Spread Over/Under
New York Jets +250 +7 (-110) Over 43.5 (-110)
New England Patriots -310 -7 (-110) Under 43.5 (-110)
Team Moneyline Spread Over/Under
Detroit Lions +700 +14.5 (-110) Over 49.5 (-115)
Los Angeles Rams -1100 -14.5 (-110) Under 49.5 (-105)
Team Moneyline Spread Over/Under
Philadelphia Eagles +116 +2.5 (-106) Over 48.5 (-110)
Las Vegas Raiders -136 -2.5 (-114) Under 485 (-110)
Team Moneyline Spread Over/Under
Chicago Bears +460 +11.5 (-110) Over 48.5 (-110)
Tampa Bay Buccaneers -620 -11.5 (-110) Under 48.5 (-110)
Team Moneyline Spread Over/Under
Houston Texans +700 +16.5 (-110) Over 48 (-110)
Arizona Cardinals -1100 -16.5 (-110) Under 48 (-110)
Team Moneyline Spread Over/Under
Indianapolis Colts +184 +5.5 (-110) Over 44.5 (-110)
San Francisco 49ers -220 -5.5 (-110) Under 44.5 (-110)
Team Moneyline Spread Over/Under
New Orleans Saints -172 -3 (-115) Over 43.5 (-105)
Seattle Seahawks +144 +3 (-105) Under 43.5 (-115)

Odds as of October 17th at FanDuel.

Unbeaten Cards Huge Favorite

Coming off their rout of the Browns, the Cardinals are the biggest favorites on the board this week. Arizona is a 16.5-point choice at home over the Houston Texans.

Kyler Murray threw four touchdown passes as the Cardinals remained the NFL’s only unbeaten team and continued their best start since 1974.

The Cardinals (6-0) built a 20-0 lead in the first half and kept their perfect record intact despite not having coach Kliff Kingsbury or star edge rusher Chandler Jones. Both tested positive for COVID-19 this week.

Murray connected with DeAndre Hopkins for two touchdowns.

The Texans (1-5) were routed 31-3 by the Colts at Indianapolis, losing their fifth straight game. Houston was down just 10-3 at halftime but were outscored 21-0 over the final two quarters.

Houston gave up two touchdown passes to Carson Wentz and two TD runs to Jonathan Taylor.

Falcons Slight Road Picks

The smallest spread is the 1.5 points the Atlanta Falcons (2-3) are favored against the Miami Dolphins (1-5) on the road.

The Falcons were off this weekend after beating the New York Jets 27-20 in London last Sunday. Atlanta has won two of its last three games following an 0-2 start.

London wasn’t so kind to the Dolphins on Sunday as they fell to the previously winless Jacksonville Jaguars 20-17 at Tottenham Hotspur Stadium despite the return of quarterback Tua Tagovailoa.

The loss was the fifth in a row for Miami and came when Jacksonville’s Matthew Wright kicked a 53-yard field goal as time expired.

Tagovailoa was back after he missed three games with a rib injury. He threw two touchdown passes to Jaylen Waddle, his former college teammate at Alabama.

Highs and Lows

The 56.5-point total for the Kansas City Chiefs’ visit to the Tennessee Titans is the biggest over/under on the slate.

That should not be a surprise considering the Chiefs are scoring and allowing a lot of points. Kansas City is averaging 30.8 a game on offense and giving up 29.3.

The Titans’ averages are 26.4 and 26.0.

The lowest over/unders are 43.5 for the New York Jets-New England Patriots game in Foxborough, as well as Broncos-Browns and Saints-Seahawks.

Out of Line?

While it’s hard to discern which team is better between the Falcons and Dolphins, Atlanta being favored by 1.5 points on the road seems a little high. Look for some money to go Miami’s way, especially with Tagovailoa back.

Considering they are just 2-4, perhaps it shouldn’t be surprising that the Patriots are just 7-point picks over the Jets. However, the Jets are the J-E-T-S and Bill Belichick is still Bill Belichick, so look for the public to bet this line up.

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