NFL Week 8 Odds – Opening Betting Lines & Spreads for All Games

• The Bills host the Buccaneers on Thursday Night Football to open NFL Week 8
• The Dolphins are the biggest NFL Week 8 opening favorite by 10.5 points over the Patriots
• A look at all the opening NFL Week 8 odds can be found below with early predictions

NFL Week 8 gets rolling with two teams coming off heartbreaking losses. Both the Tampa Bay Buccaneers and Buffalo Bills, who clash in the Week 8 TNF game, were losers during Week 7 on late-game scores.

The Bills (4-2) are 7.5-point home favorites in the NFL odds despite losing 29-25 last week at New England as the 8.5-point away chalk. Tampa Bay is 2-0 against the spread on the road this season.

Sunday Night Football features the Chicago Bears visiting the Los Angeles Chargers. The Detroit Lions are hosting the Las Vegas Raiders on Monday Night Football.

Opening NFL Week 8 Odds

Unimpressed by Patriots’ upset win over Buffalo, oddsmakers have set the Miami Dolphins as  the biggest opening favorites in the NFL for Week 8. The Dolphins are the 10.5-point home chalk against New England.

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Odds as of October 22 at FanDuel. Be sure to claim a FanDuel promo code to bet all of the Week 8 NFL action. 

As far as the smallest spread is concerned, the Atlanta Falcons – fresh off their last-second field goal win at Tampa Bay – are 1.5-point underdogs at the Tennessee Titans. The Jacksonville Jaguars are 1.5-point road favorites at the Pittsburgh Steelers. The Green Bay Packers are the 1.5-point home chalk against their NFC South rivals the Minnesota Vikings.

The largest over/under is the Patriots vs Dolphins game at 47.5 points, while the lowest total is the 36.5 points assigned to the New York Jets vs New York Giants contest.

Buccaneers vs Bills Early Odds & Predictions

Buffalo is skidding of late. The Bills are 1-2 SU and 0-3 ATS over the past three games.

When a favorite of 7.5+ points this season, Buffalo is 2-1 SU and 1-2 ATS. Last season in that scenario the Bills were 9-1 SU and 5-4 ATS.

if you or someone you know has been personally victimized by frustration due to the Buffalo Bills you may be entitled to compensation

— E💋 (@Ewaslike) October 22, 2023

Tampa Bay is 1-3 ATS over the past four games. However, the Buccaneers are 2-0 both SU and ATS this season. They were 0-6 ATS in their last six road games of the 2022 season.

All-time, the Buccaneers are 7-1-1 ATS when facing the Bills. But Tampa Bay is 0-1-1 ATS at Buffalo. This season, the Buccaneers are 2-2 ATS as a betting underdog.

Pick: Buccaneers +7.5 (-110)

Opening Bears vs Chargers Odds & Predictions

Prior to Sunday’s win over the Raiders, Tyson Bagent’s previous starting assignment was for the Shepherd Rams against the Colorado School On Mines in NCAA Division II play. He’s the first Bears QB to win his first NFL start since Craig Krenzel in 2004.

Bears rookie QB Tyson Bagent was playing Division II football last year.

He just beat the Raiders in his first NFL start.

“Don’t ever let anybody’s opinion stop you from chasing what you want.” 🙏 pic.twitter.com/4NrcXcL4Rx

— Bleacher Report (@BleacherReport) October 22, 2023

The win was the first for the Bears at Soldier Field since Sept. 25, 2022. Now they take their show on the road to face a Chargers team that is coming off a divisional loss at Kansas City. The Chargers are set as 9.5-point home favorites.

All-time, the Bears are 6-3 ATS when facing the Chargers. Chicago is 1-2 SU and ATS on the road this season. LA is 1-1 ATS as a home favorite in 2023.

Pick: Bears +9.5 (-110)

Expected Week 8 Line Movement

Is it time to admit that the Pack isn’t back, or that love doesn’t conquer all? Already this season, Green Bay has lost to the Broncos, Raiders and Falcons. QB Jordan Love and the Packers offense could only score one TD against Denver’s NFL-worst defense.

The Vikings aren’t exactly a powerhouse, but they do make a habit of beating up on the NFL’s bad teams. Green Bay now resides in that district. Minnesota is a 1.5-point road underdog at Lambeau Field. The Vikings have only been favored twice at Lambeau Field in the past three decades, but this feels like a game in which the line could swing in Minnesota’s favor.

Pick: Vikings -2.5 (-110)