Indiana vs Oregon Prediction, Spread & Best Bets for Week 7 College Football

• No. 3 Oregon hosts No. 7 Indiana in this Big Ten battle
• Both the Ducks and Hoosiers are undefeated and coming off bye weeks
• See our Indiana vs Oregon prediction, spread and best bets for Week 7 College Football

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Two Heisman hopefuls square off in a Big Ten clash with playoff implications on the line, as Dante Moore and the Ducks host Fernando Mendoza and the Hoosiers. Both teams enter this matchup at 5-0, though Oregon has been more reliable for bettors with a 4-1 record against the spread, while Indiana sits at 3-2 ATS.

Kickoff for this game is 3:30 PM ET at Autzen Stadium in Eugene, Oregon, with CBS carrying the coverage. Both of these teams are coming off a bye, so they’ve each had extra time to prepare for their biggest test of the season.

Oddly enough, this isn’t the first meeting between Moore and Mendoza.

Last time Fernando Mendoza and Dante Moore faced off:

Mendoza (Cal): 19/30, 2 TDs, 2 INT
Moore (UCLA): 25/38, 1 TD, 2 INT

Now both are Heisman candidates on Top 10 teams 👀 pic.twitter.com/cyJiLXYAmS

— BetMGM 🦁 (@BetMGM) October 10, 2025

Both quarterbacks have improved immensely since their last meeting – let’s take a deeper look into their second career matchup with our Indiana vs Oregon prediction, spread and best bets for College Football Week 7. 

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Indiana vs Oregon Prediction

• Winner Prediction: Oregon
• Spread Prediction: Lean Oregon -7 (target better in-game number)

I’m predicting Oregon to win this game, but I don’t like that the spread has moved past the key number of 7. As I will get into below, I recommend targeting a live in-game betting spot on Oregon when making your ATS prediction.

This is the Hoosiers’ biggest test since last year’s College Football Playoff loss at Notre Dame, where they fell 27-17. The final score doesn’t tell the full story, though – Indiana added some late, garbage-time points to make the margin look more respectable than it really was.

Indiana has faced only two games that could be considered “challenging” this season. One of those came against Illinois, ranked No. 9 at the time, in what was expected to be the Hoosiers’ toughest test. Instead, Indiana dominated from start to finish, cruising to a 63-10 blowout.

The Fighting Illini were clearly overrated in the top 10, but that doesn’t take away from how thoroughly the Hoosiers dismantled them.

The following week, Indiana faced a top-tier Iowa defense and narrowly escaped with a 20-15 win. Mendoza had his roughest outing of the season, completing just 13 of 23 passes (56.5%) for 233 yards with two touchdowns and one interception. Now he gets to battle against a Ducks defense that ranks 15th in EPA per play allowed. 

On the flip side, Oregon has faced just one major test this season – a double-overtime thriller against Penn State. The Ducks controlled most of the game before the Nittany Lions mounted a late surge, but Oregon held on for a 30-24 victory in one of the toughest environments in college football.

Oregon QB Dante Moore vs Penn State:

🦆 29/39
🦆 248 YDS
🦆 3 TDS
🦆 0 INTS@oregonfootball pic.twitter.com/7GfOq6mAlv

— PFF College (@PFF_College) September 28, 2025

Moore strengthened his Heisman case in that win, completing 29 of 39 passes for 248 yards, three touchdowns, and no turnovers. He’ll now go up against an Indiana defense that ranks seventh in EPA per play allowed.

However, the Hoosiers haven’t faced any truly explosive offenses this season, making it difficult to tell whether their defensive numbers reflect genuine strength or a favorable schedule.

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Indiana Hoosiers vs Oregon Ducks Best Bets

• Live Bet on Oregon to Cover Spread Under -7

I think the spread sitting at seven feels about right. Oregon is the better team across the board – they’ve got the superior quarterback and the benefit of playing at home. I wasn’t particularly high on Illinois coming into the season, so I don’t weigh that Indiana win as heavily as others might.

This matchup should look more like the Hoosiers’ close call against Iowa, where Mendoza and the offense struggled to find rhythm against a tougher defense. If I had to make a play, I’d lay the seven with Oregon, but Indiana’s offense is capable enough to hang around early with a few well-scripted drives that could keep things close or give them an early lead.

Eventually, though, I expect Oregon to pull away in the second half. My plan is to wait for a better in-game number in the first quarter, then ideally grab something under the key number of -7 with the Ducks.

Indiana vs Oregon Spread

Odds via Caesars Sportsbook as of 9:00 pm ET on Oct. 10. Grab a Caesars Sportsbook promo code to wager on Indiana vs Oregon.

This game opened with Oregon as a double-digit favorite but has since tightened to around -7 to -7.5. The total has also seen movement toward the over, climbing from 51.5 to 53.5.

It marks the first time this season that Indiana enters a game as an underdog. Meanwhile, Oregon has been favored in every contest except its road upset win over Penn State, when the Ducks were +3.5 underdogs. Interestingly, this is also the shortest line Oregon has laid all year – they’ve been favored by 24.5 points or more in every other matchup.