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Week 7 College Football Predictions – See Our Early Picks

Chris Amberley

By Chris Amberley in College Football

Published:


Indiana Hoosiers celebrate a touchdown versus Iowa Hawkeyes.
Sep 27, 2025; Iowa City, Iowa, USA; Indiana Hoosiers wide receiver Elijah Sarratt (13) reacts with offensive lineman Bray Lynch (74) after completing a 49-yard touchdown reception late during the fourth quarter against the Iowa Hawkeyes at Kinnick Stadium. Mandatory Credit: Jeffrey Becker-Imagn Images
  • Week 7 of the College Football season kicks off Wednesday
  • #7 Indiana ranks top-7 in points per game and total offense this season
  • See my favorite Week 7 College Football predictions, and the best early picks to make

It’s not every Monday that I open up my college football betting apps and see value jumping off the page. Fortunately for myself and everyone reading this, today was one of those days. I couldn’t wait to bet this slate and have listed my three college football early picks to wager on right now, as well as the reasoning behind each selection.

College Football Week 7 Picks

PickOddsSportsbook
Indiana +8.5 vs Oregon-115BetMGM
Old Dominion -14 vs Marshall-110Bet365
Iowa State -3.5 vs Colorado-110DraftKings

Odds as of Oct. 6. Check out the top college football betting apps to wager on for Week 7.

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My favorite Week 7 college football prediction is #7 Indiana plus the points against #3 Oregon. I’m also laying -14 with Old Dominion against Marshall, and backing #22 Iowa State to bounce back in Colorado after last week’s loss to Cincy.

Indiana vs Oregon Prediction

Let’s start with the Hoosiers +8.5. The opening college football Week 7 odds had Indiana catching 10 points, but I’m happy to take anything over a touchdown. These two teams are very evenly matched on both sides of the ball. They each feature a top-10 offense led by a Heisman Trophy odds contender, and a top-10 defense. Both the Hoosiers and Ducks are averaging over 40 points per outing, and are each limiting opponents to just 12 points.

Indiana Offensive Stats

StatTotal (Rank)
Points Per Game41.5 (7th)
Yards Per Game503.5 (7th)
Yards Per Play6.9 (13th)

Indiana is being downgraded for its showing in Iowa back in Week 5, but that was a sleepy spot and the team was still riding high after destroying Illinois. Oregon meanwhile, was getting all sorts of National Championship odds hype after squeaking past Penn State, but that win doesn’t look nearly as impressive after watching the Nittany Lions lose to an underwhelming UCLA program.

What makes Indiana such an attractive bet in this spot, is the havoc they can create on defense. The Hoosiers lead the nation in interception rate, and are top-13 in sacks. They’re also one of the leaders in tackles for loss, and I like their chances of slowing down Dante Moore and the Ducks attack.

This game is already down to Oregon -7.5 at most books, and could easily close under a touchdown. Grab the value on Indiana at +8.5 now before it’s too late.

  • Indiana +8.5 (-115 at BetMGM)

Old Dominion vs Marshall Pick

Moving on to Old Dominion versus Marshall, where I don’t think online sportsbooks are giving the Monarchs nearly enough credit. This is a program that’s averaging 32 points per game and 487 yards of offense. They rank fourth in yards per play at 7.6, and top-12 in both yards per carry and per pass.

They enter play with a 4-1 record, with their only loss coming to the aforementioned Hoosiers in a game where they easily covered as heavy underdogs. Old Dominion’s firepower is enough to warrant consideration in this spot, but what puts it over the top as a glaring value is the state of the Marshall defense.

The Thundering Herd are yielding 37 points per contest, despite facing just one team ranked inside the top-100. Marshall just surrendered 54 points to a lackluster Louisiana offense, after giving up 28 points to Middle Tennessee, one of the worst teams in the country.

It’s shaping up to be a long day for not only Marshall’s defense, but their offense as well. The Monarchs are top-20 in all of college football in scoring defense and yards against, and 13th in opponent red zone conversion rate.

  • Old Dominion -14 (-110 at Bet365)

Iowa State vs Colorado Best Bet

Last but not least, I’m expecting a big bounce back from #22 Iowa State versus Colorado. The Buffaloes were just annihilated by TCU dual-threat QB Josh Hoover, and the Cyclones Rocco Becht is capable of replicating that script. Becht has accounted for 16 total TD this season, including seven on the ground. Colorado is outside the top-85 in yards per carry and rushing yards allowed, and 91st in yards per pass.

On the other side of the ball, Colorado’s QB situation remains a mess. Kaidon Salter was picked off three times by the Horned Frogs, and has thrown for less than 200 yards in three of five starts. You can expect more trouble for Salter and whoever else the Buffs line up behind center, as Iowa State is yielding only 6.5 yards per pass and a 61% completion rate.

The Buffaloes are 0-4 straight up versus top-60 teams this season, with an 8.25 point average margin of defeat.

  • Iowa State -3.5 (-110 at DraftKings)
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Chris Amberley
Chris Amberley

Sports Writer

As SBD's resident Swiss Army Knife, Chris covers virtually every sport including NFL, PGA, NBA, MLB, NCAAB, NCAAF and the Olympics. A true grinder, he'd rather pick off small edges in the player props market than swing for the fences with a 5-leg parlay.

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