Dallas Cowboys vs LA Rams – Odds, Lines, Spread, and Picks NFL Week 5

By Eric Rosales in NFL Football
Published:

- The Dallas Cowboys seek a fourth straight win when they visit the LA Rams
- Cooper Rush will seek his fifth straight win as a Cowboys’ starting QB
- See the Cowboys vs Rams picks and odds ahead of their Week 5 clash, and our pick below
How’s this for a weird season: it’s the Dallas Cowboys and backup Cooper Rush trying to stay red-hot as they take on the struggling defending World Champion-LA Rams.
Yet that’s where we are in Week 5, where the Rush will seek his unprecedented fifth-straight win as Dallas’ starter in his first five starts.
The Rams are trying to pick up the pieces after a Monday-night drubbing, and have yet to record an impressive W yet this season.
Oddsmakers aren’t showing much faith in the Cowboys, installing them as 5.5-point underdogs in this all-NFC matchup.
Cowboys vs Rams Odds
Team | Moneyline | Spread | Total |
---|---|---|---|
Dallas Cowboys | +188 | +5.5 (-108) | Ov 43 (-110) |
Los Angeles Rams | -235 | -5.5(-113) | Un 43 (-110) |
Odds as of October 8th from Barstool Sporstbook.Â
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Bettors aren’t backing the home team, according to NFL Betting Trends, where 67% of the bets are on the Cowboys, though 61% of the wagers on the moneyline are on the Rams.
Kickoff goes Sunday (October 9) from SoFi Stadium at 4:25pm ET, in a game that can be seen live on FOX.
Dallas Betting Outlook
There’s nothing that props up a 26th-ranked offense like a destructive defense.
That’s the cushion Rush has been allowed to play on, as Dallas’ D is proving to be one of the best in the NFL. They are allowing the third-fewest points, and own the sixth-best pass defense. They made life miserable for Carson Wentz last time out, picking him off twice in a 25-10 win.
Trevon Diggs with a Interception 🤩🔥pic.twitter.com/4WbqOQkbDM
— Alabama DieHards (@DiehardsAlabama) October 2, 2022
Part of their success stems from a relentless pass rush, which is tied for third in the NFL with 15 sacks. They’re disruptive even when they don’t get home, ranking second in pressure rate and third in QB pressures.
If there is a way to puncture the Cowboys’ front, it might be the run game, where they rank just 27th.
Micah Parsons this season:
🤠118 snaps
🤠0 missed tackles
🤠4 sacks
🤠22% pressure percentage pic.twitter.com/oKXvBnsa6K— PFF (@PFF) September 23, 2022
Still, that side of the ball has made Rush’s mistake-free play invaluable to a team that looked absolutely lost when Dak Prescott went down with a thumb injury. Prescott has already been ruled out of this one, but perhaps the Rush run has just one last stop.
On the season, he’s completing 60.8% of his passes, throwing for 737 yards and four touchdowns. While he hasn’t crossed 235 yards passing in any game, Rush hasn’t thrown an interception in 102 straight passes.
Los Angeles Betting Outlook
There’s still a long way to go, but as of right now, it’s looking like there won’t be a repeat champion.
Los Angeles was dismantled 24-9 against the 49ers Monday Night, and their division foe showed the glaring weakness that Dallas will want to exploit early and often: a patchwork offensive line.
Death, Taxes, and a Matt Stafford INT https://t.co/35Uv5G6Er9
— Kinny (@KinnyGames) October 4, 2022
Matt Stafford went 32-for-48 for 254 yards and an interception that went for six, and was under siege all evening, taking seven sacks and 12 QB hits.
Aside from Cooper Kupp, who’s been still lighting defenses on fire, the only dependable playmaker on the roster so far has been Tyler Higbee, with 26 grabs.
Sean McVay hasn’t been able to scheme his other offensive pieces into the mix. Allen Robinson has only nine catches on the year, Ben Skowronek has 12 catches, and Darrell Henderson and Cam Akers have combined to run for just 256 yards.
Samson Ebukam with the sack on Stafford!
🎥: @NFL pic.twitter.com/Wh3UsOIJAy
— OurSF49ers (@OurSf49ers) October 4, 2022
To put that into context, Dallas’ Zeke Elliott hasn’t been even close to remarkable this year, but has 227 rush yards on his own.
Perhaps they can get a spark from their defense. Jalen Ramsey should be blanketing CeeDee Lamb, and a front that only had a single QB hit against the 49ers can bounce back behind Aaron Donald.

Cowboys vs Rams Pick
This game will break an all-time 18-18 mark between these two teams. LA has won three of the last four head-to-heads, and Dallas still hasn’t won a game in St Louis/LA since 2014.
SoFi is already known as a visiting team’s extra home game, and perhaps no team fan base travels better than the Cowboys.
Couple that with the fact the Cowboys are 5-0 against the spread in their last five road games, and the Rams are 1-4 ATS in their last five home games, and it’s hard to back the home team, even as defending champions going against a backup.
Weird, right?
The Pick:Â Â
- Cowboys +5.5 (-108); 1 unit to win 0.93 units
- Week 4 record: 1-1; Overall: 3-5 ATS, 1-0 O/U, -4.76 units

Sports Writer & Editor
Having worked in and around sports since 1997, Eric is truly a knowledgeable expert. The two-time journalism grad specializes in all things NBA and NFL. From TSN.ca to CTV's Olympic Broadcast Consortium, Eric's work has appeared in local and national publications alike.