IND Pacers vs CLE Cavaliers Game 2 Picks, Predictions, Player Props & Best Odds

• The Cleveland Cavaliers are heavy favorites to even their best-of-seven series with the Indiana Pacers on Tuesday
• Three Cavaliers are listed as questionable on the injury report for Game 2, including Darius Garland and Evan Mobley
• See the Pacers vs Cavaliers picks, predictions, player props, and best odds for Game 2 on May 6

The Cleveland Cavaliers (64-18, 34-7 home) try to avoid falling in an 0-2 hole in their best-of-seven series with the Indiana Pacers (50-32, 20-20 away) on Tuesday night when the teams meet at Rocket Arena at 7:10 pm ET.

Indiana beat Cleveland for the fourth time in five tries this season on Sunday, earning a massive 121-112 road win as 8.5-point underdogs. But sportsbooks expect Cleveland to answer back in Game 2, setting the Cavs as high as 9.5-point home favorites in Tuesday’s NBA odds.

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Pacers vs Cavaliers Picks & Predictions for Game 2

• Pacers moneyline (+328) at Caesars
• Tyrese Haliburton over 18.5 points (-111) at BetMGM
• Pascal Siakam under 19.5 points (-115) at Draftkings

Three-point shooting was the difference in Game 1 on Sunday. Indiana connected a a ridiculous 52.8% clip (19-of-36) while the Cavs shot just 23.7% from beyond the arc. That stands in stark contrast to the regular season when Cleveland finished second in the NBA in 3P% (38.3%), a full 1.5% higher than Indiana (36.8%).

But don’t necessarily expect the script to flip in Game 2. I’ve been saying all season that Cleveland’s quantum leap in shooting was unsustainable. With basically the same roster, the Cavs finished 15th in the league in 3P% (36.7%) and 13th in the NBA in EFG% (55.7%) during the 2023-24 season. Yet, in 2024-25, they led the league with a 57.8% EFG.

In 2023-24, it was the Pacers who led the league in EFG at 57.8%. And, much like the Cavs, the Pacers roster has seen little turnover during the last two seasons.An entire regular season isn’t a small sample size, but taking a broader, 200-foot view, there’s ample evidence that Indiana’s offense is every bit as good as Cleveland’s.

The Cavaliers also have three significant injury concerns heading into Game 2: Darius Garland (20.6 PPG, 2.9 RPG, 6.7 APG), who’s missed three straight games, remains questionable with a toe injury. Evan Mobley (18.5 PPG, 9.3 RPG, 3.2 APG) is also questionable with an ankle issue, while De’Andre Hunter (17.0 PPG, 4.0 RPG) is questionable with a thumb injury.

While I’m backing the Pacers to pull another upset, I’m fading their leading scorer Pascal Siakam’s point total. After a 17-point performance in Game 1, on an ugly 6-of-15 performance from the field, Siakam (19.3 PPG, 6.43 RPG, 2.7 APG postseason) has now gone over 19.5 points just once in four tries against the Cavs this season. He’s averaging 17.0 PPG in that quartet of games with Cleveland.

Indiana’s Game 1 victory was powered by its depth. No one took more than Siakam’s 15 field-goal attempts, and no one connected at a lower rate than Siakam’s 40% clip. When this Pacer offense is at its best, point guard Tyrese Haliburton (18.3 PPG, 5.8 RPG, 11.8 APG) is evenly distributing to Indiana’s myriad options all over the floor.

Unlike Siakam, though, Haliburton has had a ton of scoring success against the Cavs this season. He’s scored 22 or more in three of his four games against Cleveland. In the fourth (Jan 12), he sat out the entire second half due to a hamstring injury. He was more aggressive shooting the ball in Game 1 than usual, and it paid off, going 9-of-15. That was more reminiscent of the Haliburton fans saw from 2022 to 2024, when he averaged 15.1 FG attempts per game and over 20 PPG.

Indiana head coach Rick Carlisle should be encouraging Haliburton to call his own number whenever he pleases.

IND vs CLE Player Props for Game 2

NBA player props from bet365 on May 6

After a 33-point performance in Game 1 on an inefficient 13-of-30 shooting from the field, Donovan Mitchell’s point total has increased from 26.5 on Sunday ot 28.5 O/U tonight. On the Indiana side, Pascal Siakam continues to lead the point totals at 19.5. He had just 17 on 6-of-15 shooting on Sunday.

Jarrett Allen has the highest rebound total for Game 2 at 10.5 O/U. He recorded just five rebounds in 30 minutes during Game 1..

Tyrese Haliburton, who poured in 22 points and 13 assists in Game 1, has a game-high assist total of 10.5 once again.

Indiana Pacers vs Cleveland Cavaliers Odds (Game 2)

As of 10:08 am on Tuesday morning, the Pacers/Cavaliers spread still showed a one-point range across sportsbooks. Most have it at Cleveland -9.0 but BetMGM has it half a point higher, making it the best option for Indiana ATS bettors, while ESPN Bet has it half a point lower, making it the best option for Cleveland ATS backers.

On the moneyline, Caesars has the longest odds on an Indiana SU victory at +328. DraftKings is the only book with the Cleveland moneyline longer than -400.

There isn’t any real variety when it comes to the game total, unfortunately. All sportsbooks have it at 229.5 for the second straight game.

Cleveland’s NBA championship odds faded to +575 after losing Game 1 while Indiana’s are now as short as +3000.