Arizona Cardinals vs Seattle Seahawks Odds, Predictions and Best Bets for Week 6

• Arizona visits Seattle for a Week 6 NFC West showdown
• The Cardinals are 0-4 against the spread in their last 4 games vs the NFC West
• Explore all the Arizona Cardinals vs Seattle Seahawks odds and our best bets below

Kyler Murray and the Arizona Cardinals visit Lumen Field for a battle with the Seattle Seahawks on Sunday. Each of these teams will be hoping to ignite their seasons with a key divisional match-up victory.

The Cardinals head to Seattle after backup kicker Matt Ammendola booted a 43-yard field goal try wide right as time expired last week. Despite that, Arizona put up a valiant effort against the undefeated Philadelphia Eagles, losing the game 20-17.

Seattle will be out to avenge a defeat of its own, as the Seahawks lost a back-and-forth shootout 39-32 to the New Orleans Saints.

This Arizona Cardinals vs Seattle Seahawks showdown kicks off on Sunday at 4:25 ET over on Fox. Until then, take a peek at all the odds and our best bets for this NFC West matchup.

Arizona Cardinals vs Seattle Seahawks Odds

Odds as of October 14th at BetMGM.

The Seattle Seahawks enter this NFC West matchup as a +125 moneyline home underdog. The total is set at 50.5 for this Arizona vs Seattle game.

So far, 86% of bettors like the Arizona Cardinals to cover the 2.5-point spread.

Arizona Cardinals Betting Trends

The Arizona Cardinals may be one of the NFL’s most frustratingly unpredictable teams, however, one trend keeps them alive in bettors’ minds. Kliff Kingsbury covers on the road. Especially against the rest of the NFC West.

Bettors hoping to be back the Cardinals will be grateful that this one takes place on the road. Arizona has lost all three home games this season, and eight straight since last year. However, the Cardinals are 10-2 against the spread in their last twelve road games.

This Cards greatest path to victory this year has been relying on quarterback Kyler Murray to play hero ball. Luckily Kyler is 17-6-2 against the spread as the visiting team in his career, and this week he gets a treat of a match-up against a porous Seahawks secondary.

Kyler Murray’s accuracy remains insane. pic.twitter.com/0eNxphUdzl

— Johnny Venerable (@JohnnyVenerable) October 12, 2022

Appealingly, the Cardinals are 6-1 against the spread in their games played in Seattle.

Seattle Seahawks Betting Trends

After being sleepless in Seattle for so many years, the Seahawks’ offense has finally woken up. Seattle quietly ranks seventh in points per game (25.4) and eighth in yards per game. Geno Smith, yes that Geno Smith, leads the league in passer rating, completion percentage over expectation and overall PFF grade. In other words, Geno is cooking. If the Seahawks were 4-1 instead of 3-2, there’s no doubt Geno Smith would be smack dab in the MVP conversation. Just as we all predicted.

Highest passer rating in Week 5:

Geno Smith – 139.5 🧑‍🍳🧑‍🍳 pic.twitter.com/OSCv0dzZLD

— PFF (@PFF) October 10, 2022

As great as the Seahawks’ offense has been this season, they haven’t been able to cover for a dreadful defensive unit.

Seattle’s defense ranks dead last in total yards allowed at over 430 per game. Additionally, the Seahawks rank last in rushing yards allowed and next to last in points surrendered at over 30 per game. This defense may be the single worst unit in the National Football League.

Many would look for a Geno Smith (#letgenocook) backdoor cover as a home dog in this one. But, this defense is impossible to rely on in any situation. There’s a reason the over is 6-1 in the Seahawks last seven games played against the NFC.

Arizona Cardinals vs Seattle Seahawks Picks

Ultimately, there’s no value in betting with a porous Seahawks defense as a home underdog. As noted above, the Cardinals are a much better road team and should have no problem covering a 2.5- point spread.

Pick: Arizona Cardinals -2.5 (-115)