Arizona Diamondbacks vs San Francisco Giants Odds, Picks & Player Props

• The San Francisco Giants continue their playoff push against the Arizona Diamondbacks on Wednesday
• Struggling starters Eduardo Rodriguez (5.22 ERA) and Carson Seymour (4.25 ERA) take the mound
• See my favorite Diamondbacks vs Giants picks and player props to bet, plus the best available odds

The San Francisco Giants (74-71, 37-34 home, 67-71-6 O/U) close out a three-game series with the Arizona Diamondbacks (72-74, 34-40 away, 69-69-7 O/U) in a Wednesday matinee at Oracle Park (12:45 pm PT/3:45 pm ET).

The Giants took the first two games of the series and, thanks to a 13-3 record in their last 16 games, are within two games of the Mets for the final NL Wild Card with 17 games remaining.

San Francisco will send Carson Seymour (1-2, 4.25 ERA) to the mound on Wednesday, while Arizona counters with veteran lefty Eduardo Rodriguez (7-8, 5.22 ERA), who is searching for consistency in what has been a challenging season.

Diamondbacks vs Giants Odds

Wednesday’s MLB odds slightly favor the Giants on the moneyline (-126) with the Diamondbacks priced as +104 road underdogs. The tame total is sitting at 8.5 runs with roughly even odds each way. Without the juice, the moneyline odds give the Giants a 53.2% implied win probability and the Diamondbacks the remaining 46.8%. Odds as of September 10 at DraftKings. See the full list of DraftKings legal states.

SFG vs ARI Odds Movement

The betting market has steadily moved in favor of San Francisco. After opening at -115, the Giants’ moneyline has shifted to -126, indicating that early money, supported by public betting volume, is backing the home team.

The total has held firm at 8.5 runs, but the price on the Over has moved from -101 to -109, suggesting that bettors are anticipating a higher-scoring affair, likely due to the struggling starters.

This sentiment is backed by MLB public betting splits, which show over 70% of wagers on the over. The over has cashed in five consecutive meetings between the teams.

Starting Pitcher-vs-Batter H2H History

Rookie Seymour has only made one previous appearance against the Diamondbacks, back on July 1st. He pitched 3.0 innings allowing four runs (only two earned) on five hits and no walks with two strikeouts.

Arizona Diamondbacks Career Statistics vs Carson Seymour

Three of Arizona’s five hits off of Seymour in July were home runs, but James McCann is the only player still on the active roster who had one of the long balls.

San Francisco Giants Career Statistics vs Eduardo Rodriguez

Rodriguez, a ten-year vet, has considerably more history against the San Francisco lineup (50 total at-bats). The Giants have accumulated a respectable .260 average and .827 OPS against the lefty. Matt Chapman and Casey Schmitt have the only two home runs. Chapman’s five RBI off of Rodriguez are nearly half of the 11 that the San Francisco lineup has generated as a group.

Giants vs Diamondbacks Player Props

MLB player props as of 12:15 pm ET at DraftKings.

Rodriguez’s strikeout line of 4.5 is attainable, but his earned runs line of 2.5 is precarious against a Giants lineup that has had some success against him. Matt Chapman and Casey Schmitt have both taken him deep in limited at-bats.

Carson Seymour’s strikeout prop is a low 3.5, suggesting oddsmakers expect the Diamondbacks to put the ball in play. His outs prop of 14.5 indicates a shorter leash, meaning he’ll need to be efficient to pitch into the sixth inning.

Given the high-scoring trends in this series, targeting the over on earned runs for both pitchers could hold value.

SF Giants vs ARI Diamondbacks Picks

• San Francisco Giants Moneyline (-126)
• Over 8.5 Runs (-109)

The momentum in this matchup overwhelmingly favors the Giants. They are playing their best baseball of the season at the right time, while the Diamondbacks are hampered by injuries and mired in a slump, especially on the road.

The pitching matchup, while not featuring aces, also leans toward the home team. Carson Seymour has been serviceable, and he’s backed by a bullpen that has been elite. Conversely, Eduardo Rodriguez has been unreliable all year with a 5.22 ERA, and he faces a Giants lineup that has found its rhythm.

Several powerful betting trends support a play on San Francisco. The Giants are an astounding 10-1 (.909) as a favorite in their last 11 games and have won their last six games at home when favored. Even more compelling is their 8-1 (.889) record in their last nine games at Oracle Park. On the other side, the Diamondbacks have been dreadful on the road following a loss, posting a 1-6 (.143) record in their last seven.

While both pitchers are vulnerable, the Giants’ superior bullpen and red-hot offense should be the difference-maker.

The trends for the total are also hard to ignore. The over has cashed in each of the last five meetings between these clubs and in the last five Giants home games. Expect San Francisco’s offense to get to Rodriguez early and for the game to sail past the total.