A.I. NFL Picks for Week 6 – ATS and O/U A.I. Predictions for All 15 Games
By Sascha Paruk in NFL News
Published:
- Our A.I. model is coming off a 10-3 ATS performance last week
- I have generated ATS and O/U picks for every Week 6 NFL game
- Below, see our A.I.’s NFL picks for Week 6, including its favorite pick against the spread and game total in each game
A lackluster start to the season from our A.I. turned around in a big way on Sunday. It went 10-3 ATS and 7-6 O/U heading into tonight’s MNF game between the Chiefs and Jaguars (where it has Jacksonville +3.0 and under 45.5).
I have already asked our A.I. to generate its picks for NFL Week 6, which features 15 games, including Broncos vs Jets in London and a Monday Night Football double-feature (Bills/Falcons and Bears/Commanders). You can see the opening NFL Week 6 odds here. The table below sets out our A.I. NFL picks for Week 6, including its favorite ATS and O/U bet for all 15 games on the docket.
A.I. NFL Picks for Week 6
*Denotes neutral-field game in London, UK.
Even after a brilliant Week 5 performance, the A.I. is still under .500 (both ATS and O/U) this season. But it does seem to be improving with more input; it’s one game over .500 on its ATS picks from Week 3 to Week 5.
A.I. ATS record to date: 36-41
A.I. O/U record to date: 33-44
Week 6 A.I. Picks Heavily Backing Favorites
The A.I. picks for NFL Week 6 are all over the favorites. The A.I. has picked 13 of 15 favorites to cover the spread. The only underdogs it’s taking in Week 6 are the Lions (+1.5 at the Chiefs) and Titans (+5.5 at the Raiders).
It’s skewed to favorites all season, but this is by far the most-favorite-heavy slate of picks it has provided this season.
It’s slant towards the chalk is not unwarranted; favorites are 41-36 so far in the 2025 NFL regular season.
The A.I. took seven underdogs in Week 5 (including the Jaguars in their MNF game with the Chiefs tonight) and so far it’s 6-0.
Click the links below if you want to tail its two underdog picks in Week 6.
A.I NFL Picks 4-0 ATS on Jaguars Games But 0-4 O/U
One team that the A.I. seems to have a bead on is the Jaguars, at least when it comes to the spread. Heading into Jacksonville’s MNF showdown with the Chiefs tonight, the A.I. is 4-0 ATS on Jags games this season, taking them to cover in Weeks 1, 3, and 4, and fading them in Week 2 at Cincinnati.
The A.I. is backing Jacksonville as a slight 1.5-point home favorite against the visiting Seahawks in Week 6. That line is actually as long as JAX +1.5 (-115) at DraftKings.
Ironically, the A.I. is 0-4 O/U on Jacksonville games. Betting them to go over in Week 1 and stay under in each of the last three games. It has Seahawks/Jaguars staying under 44.5 in Week 6, in case you want to fade that pick.
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Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
