San Francisco 49ers vs Tampa Bay Buccaneers Picks, Player Props & Latest Odds (Week 6)

• Two 4-1 teams clash when the San Francisco 49ers visit the Tampa Bay Buccaneers
• The 49ers are a dismal 1-12 ATS in their last 13 games following a win
• See my 49ers vs Buccaneers picks and predictions plus the latest odds (spread, total ML)

First place in the NFC will be on the line – at least for the time being – when the San Francisco 49ers (4-1, 3-2 ATS, 3-2 O/U) travel to face the Tampa Bay Buccaneers (4-1, 2-3 ATS, 3-2 O/U) at Raymond James Stadium in Tampa, Florida, at 4:25 pm ET in Week 6. The weather forecast calls for partly cloudy skies with a temperature of 73°F and a northeasterly wind of about 14 mph, which should have minimal impact on the game.

The Buccaneers are riding high after a thrilling 38-35 win at Seattle last time out. The Niners keep manufacturing wins despite a slew of significant injuries on both sides of the ball, eking out a 26-23 OT win at the Rams on TNF last week as eight-point road underdogs.

With Mac Jones still under center in place of injured QB1 Brock Purdy, the 49ers vs Buccaneers odds have moved in favor of the home team over the week, even though Tampa is also dealing with a rash of key injuries.

Below, I have set out (1) my 49ers vs Buccaneers picks and predictions, (2) the main SF vs TB player props, and (3) the latest Niners/Buccaneers betting odds. Use the following links to navigate directly to each section.

PICKS || PLAYER PROPS || LATEST ODDS

San Francisco 49ers vs Tampa Bay Buccaneers Picks & Predictions

• San Francisco 49ers +3.5 (-11)
• Under 47.5 (-122)
• Christian McCaffrey Over 6.5 Receptions (+100)

This game has compelling trends pulling in opposite directions. The 49ers have been road warriors, winning and covering in all three of their away games this season. However, they have been posed an unbelievably poor 1-12 ATS record after a win and an 0-6 ATS record as an underdog of fewer than seven points.

Meanwhile, the Buccaneers have been dominant this season but have failed to cover the spread in their last four home games, a troubling trend for a home favorite.

While the line has moved in Tampa Bay’s favor (Tampa opened at -2.5 and has been bet up to -3.5), the underlying matchups suggest a closer game. The Buccaneers’ offense, led by an efficient Baker Mayfield, faces its toughest test against a 49ers defense that ranks among the league’s elite in yards per play. The critical battle will be in the trenches, where San Francisco’s formidable run defense will look to neutralize Rachaad White and make Tampa Bay one-dimensional. The 49ers have owned this head-to-head series, winning the last four meetings. Their defense travels well, and their methodical offense is built to control the clock, which is the perfect recipe for a road underdog.

Given the 49ers’ perfect road record this season and Tampa’s penchant to play close games, no matter the opponent, taking the points is the logical play. All four of Tampa’s wins this season have come by three points or fewers (and by a total of nine points).

The Buccaneers’ struggles to cover at home are too significant to ignore, especially against a quality opponent. The total dropping two points from 48.5 to 46.5 is also telling; with San Francisco’s red-zone woes and Tampa Bay facing a top defense, points could be at a premium. I’m backing the trends that favor the underdog and a tighter, lower-scoring affair.

SF 49ers vs TB Buccaneers Player Props

NFL player props from DraftKings as of Oct. 12. See the full list of DraftKings legal states.

Jones has a massive passing-yards line of 252.5 with the under only slightly favored at -113. That’s 12 yards higher than Mayfield at 240.5, who is also priced at -113 to stay under.

Christian McCaffrey’s receiving-yards prop (51.5) is only five yards lower than his rushing-yards prop (56.5). With so many San Francisco pass catchers out (), CMC has had to be even more all-purpose than usual this season.

San Francisco 49ers vs Tampa Bay Buccaneers Odds

Roughly three hours before kickoff, the best moneyline price on Tampa Bay is -174 at FanDuel, while the best ML for the Niners is +155 at bet365. The spread is TB -3.5 across the board with only slight variations in price. All books have a little extra juice on the Niners to cover the spread. The game total is as low as 46.5 after opening at 48.5. BetMGM is still offering the total at 47.0 with -110 odds each way.

Without the juice, the current moneyline odds give the Buccaneers a 62.3% implied win probability, leaving just 37.7% for the 49ers.

Odds commentary as of 1:23 pm ET. The NFL odds in the table will update automatically with the best available price for each market if the odds move before kickoff

SF vs TB Public Betting Splits

The NFL public betting patterns indicate that the public is leaning towards the Buccaneers at home, while sharper, more respected bettors are taking the San Francisco 49ers plus the points.

A similar split is seen on the total, with public money favoring the over and sharp action driving the line down to 46.5.