Murray State vs Duke Odds, Picks & Best Bets (Super Regionals)

• Duke is a -360 moneyline favorite over Murray State in Game 1 of the Durham Super Regionals on Saturday
• Nic Schutte (8-3, 4.55 ERA) is expected to start for the Racers, while the Blue Devils will counter with Owen Proksch (3-3, 4.83 ERA)
• Keep reading for the Murray State vs Duke odds, plus picks and best bets below

Nobody expected Murray State to still be standing on Super Regionals weekend. Yet here they are, about to face Duke in a best-of-three series for a berth in the 2025 College World Series. Game 1 goes on Saturday, June 7, and online sportsbooks are not expecting the Racers’ Cinderella run to continue. They’ve labelled the Blue Devils mega-chalk ahead of the series opener in front of the hometown Duke fans.

First pitch is scheduled for 1pm ET at Jack Coombs Field in Durham, North Carolina, with ESPNU and ESPN+ providing the broadcast and streaming coverage.

Murray State vs Duke Odds

The Blue Devils are currently -360 moneyline favorites, and are laying 3.5 runs on the spread. Murray State comes back as a +260 underdog, while the run total sits at 13.0.

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Murray State vs Duke Picks and Best Bets

• Duke Blue Devils Over 7.5 Runs (-130) at bet365

The Racers will send junior Nic Schutte to the mound, after he was roughed up in the Regionals. Schutte had an excellent 2025 campaign against inferior mid-Major opposition, but reality struck hard once he had to face elite SEC competition.

Schutte made two appearances last weekend against Ole Miss, and was shelled for 7 hits and 9 earned runs over 8.2 innings of work. Despite his 8-3 record, the righty has battled control issues all season long. He’s allowed 3 or more walks in five straights, and 6 home runs over that stretch. That’s problematic against the Duke lineup, which is as patient and dangerous as they come.

Duke ranks fifth in weighted runs created, and 12th in OBP. They own the nation’s number one walk rate, and one of its lowest strikeout rates. Ben Miller is the team’s number one power option with 20 home runs, while 11 players boast an on base percentage of .400 or better.

Nick Shutte vs Owen Proksch Stats

The Blue Devils scored 21 times in three Regional Round matchups last week, posting a +11 run differential. Not only is Schutte ripe for the picking, but the rest of the Murray State staff is as well. Over the last 10 games, that unit has an ERA over 7.00.

As for the Racers’ bats, they’re one of the few reasons this team is still left in the College World Series odds. They outslugged Ole Miss and Georgia Tech in the Regionals scoring 33 runs, but their pitching staff allowed 41.

Murray State’s arms coughed up 11+ runs in all three outings, including 19 in a lopsided defeat to the Rebels. I’m predicting Duke will easily exceed its 7.5 run team total, while the Racers will have a tough time keeping pace.

The Blue Devils allowed only 10 runs total over Regionals weekend, and will turn to Owen Proksch on Saturday. The southpaw struck out 8 Oklahoma State batters last time out, yielding just 3 hits and 2 runs in a victory. He’s allowed 2 runs or less in 12 of 18 appearances this season, posting 84 strikeouts in only 59.2 innings of work.