Iowa State vs Creighton Prediction, Odds & Props – Is Tamin Lipsey Playing Today?

• Iowa State’s potent offense (93.0 PPG) creates a significant mismatch against Creighton’s methodical attack
• Sharp money is backing Creighton to cover despite public sentiment favoring Iowa State
• See the best Iowa State vs Creighton picks, predictions, odds, and betting splits

The undefeated Iowa State Cyclones (5-0, 3-1-1 ATS, 4-1 O/U) clash with the Creighton Bluejays (3-2, 1-4 ATS, 0-5 O/U) in a marquee neutral-site battle on Tuesday at 2:00 pm ET. This Big 12-versus-Big East showdown takes place at \Michelob ULTRA Arena in Paradise, Nevada, with truTV broadcasting the action.

The Cyclones survived their first real test of the season yesterday, overcoming an eight-point second-half deficit to eke out an 83-82 win over # St John’s, boosting their record to 2-0 record in neutral-site games. Star senior guard Tamin Lipsey (18.4 PPG, 3.6 RPG, 5.2 APG, 3.2 SPG) exited late with an injury are his status for Tuesday is uncertain. He is officially a game-time decision and his status won’t be determined until tip-off.

The Bluejays remain winless away from home (0-1 away, 0-1 neutral) after falling to Baylor (81-74) last night. Despite Lipsey’s injury concerns, the Cyclones are sizable favorites in the Iowa State vs Creighton odds, ranging from 5.5 to 6.5-point chalk with the total sitting between 150.5 and 151.5. Creighton is a perfect 5-0 to the under so far this season.

Iowa State vs Creighton Expert Picks & Predictions

Iowa State’s offensive superiority is the most-telling factor. While Creighton has faced a higher quality of competition this season, the Bluejays lack the consistent scoring punch to match the Cyclones’ relentless attack. Iowa State’s ability to control tempo and exploit defensive mismatches should lead to a comfortable ISU victory.

ATS Pick: Iowa State -5.5 (-110) at DraftKings

This recommendation centers on the massive offensive disparity between these programs. Iowa State’s trio of primary scorers – Lipsey and Jefferson both averaging 18.4 PPG alongside Momcilovic’s 16.8 PPG – presents a balanced threat that Creighton will struggle to match, even if Lipsey is sidelined.

Iowa State’s offensive efficiency metrics support this advantage. The Cyclones connect on 52.2% of field-goal attempts while maintaining excellent ball security with a 1.87 assist-to-turnover ratio. Lipsey’s individual command of the offense shines through his elite 6.5-to-1 assist-to-turnover mark, enabling seamless ball movement that creates quality scoring opportunities.

The line movement from an opening 9.5-point spread down to 5.5 – a result of the Lipsey injury – has created solid value on the Cyclones. Iowa State is 3-1-1 ATs this season, demonstrating an ability to meet elevated expectations, while Creighton’s ugly 1-4 ATS mark is a sure sign that the Bluejays have taken a step back. Creighton has a pedestrian 45.3% field goal percentage and concerning 29.1% three-point clip early in the season.

Game-Total Pick: Over 150.5 (-110) at DraftKings

This represents a straightforward numbers play based on offensive output trends. The combined scoring average of 170.6 points per game sits 18.1 points above the current total, creating substantial cushion for this wager. Iowa State’s pace-pushing style should force Creighton into a faster game than their typical methodical approach.

The total has already climbed from its opening 150.5, indicating sharp money anticipates a high-scoring affair. Iowa State’s defensive metrics (66.2 PPG allowed) suggest they won’t completely shut down Creighton’s attack, while the Bluejays’ defensive struggles (70.4 PPG allowed) create opportunities for the Cyclones to approach triple digits.

Historical trends favor the over in neutral-site games featuring teams with contrasting tempos. Iowa State is 4-1 to the over this season and should control the tempo against a Creighton team that’s 0-5 O/U.

Best ISU vs CRE Player Prop: Momcilovic Over 2.5 Threes (-137) at Underdog

Momcilovic presents exceptional value in the three-point market based on volume and efficiency metrics. The marksman attempts 7.8 treys per game while connecting at an outstanding 46.2% clip, having drained 18 threes across five contests for a 3.6 per-game average.

Creighton’s defensive scheme typically focuses on limiting penetration, potentially creating additional perimeter opportunities for Iowa State’s shooters. Jefferson’s interior presence (59.3% FG) and Lipsey’s driving ability should collapse defenders, generating clean catch-and-shoot looks for Momcilovic on the wings.

Momcilovic has cleared 2.5 makes in four of five games, including a 5-of-8 performance last night.

Iowa State Cyclones vs Creighton Bluejays Odds

The line ranges from Iowa State -5.5 to -6.5 after opening at 9.5, as mentioned. The best ISU ATS option is -5.5 at DraftKings while the best Creighton ATS option is +6.5 at FanDuel. DraftKings also has the best number for over bettors at 150.5, while ESPN Bet has the best number for under bettors at 151.5.

Odds and commentary as of 11:32 am ET. Bookmark SBD’s college basketball odds page to see up-to-the-minute lines.

ISU vs CRE Public Betting Breakdown

The college basketball public betting splits highlight a potential contrarian angle on the point spread, while showing strong consensus on the game’s outcome and total points.

Public sentiment strongly aligns with our primary recommendations on two fronts. Iowa State draws overwhelming support on the moneyline with 97.56% of tickets and 96.33% of handle, indicating both casual and professional bettors expect the Cyclones to maintain their perfect record. This unanimous backing reinforces our confidence in Iowa State’s superiority.

The total presents similar consensus, as 68.94% of bets target the Over, with 72.47% of money flowing in that direction. This heavy action has pushed the line upward from 150.5, suggesting the market recognizes these teams’ offensive capabilities exceed the initially posted number.

The point spread reveals the session’s most compelling contrarian opportunity. While 57.2% of tickets back Creighton +6.5, the money split heavily favors the Bluejays at 68.47% of handle. This indicates larger, presumably sharper wagers are backing Creighton to cover despite our statistical analysis favoring Iowa State.

This sharp-versus-public split typically emerges when professional bettors identify line value that contradicts popular opinion. However, the offensive efficiency, pace metrics, and historical performance in similar spots supports fading this sharp money and backing Iowa State’s ability to cover the reduced number.

Sign Up for SBD’s Newsletter Now

Did you want the latest sports betting news, analysis, picks, betting trends, and relevant data straight to your inbox? If so, you’ll want to subscribe to SBD’s newsletter now!