Missouri vs Kansas Picks, Predictions, Odds & Betting Splits (Dec. 7)

• The 6-3 Jayhawks enter as 6.5-point favorites over the 8-1 Tigers on Dec. 7, 2025
• Sharp money has driven the total down from 154.5 to 150.5
• See the Missouri vs Kansas picks, predictions, latest odds, and betting splits for Sunday afternoon

The historic Border Showdown returns as the Kansas Jayhawks (6-3, 2-1 home, 5-4 ATS, 2-7 O/U) and Missouri Tigers (8-1, 1-1 away, 4-5 ATS, 4-5 O/U) renew their heated rivalry at T-Mobile Center in Kansas City, MO. Oddsmakers heavily favor Kansas, despite the Jayhawks’ pedestrian win/loss record.

The Tigers, ranked 38th at KenPom, built their 8-1 mark against soft opposition, losing their lone game against a top-100 KenPom opponent so far this season (a 76-71 loss at Notre Dame last time out). Conversely, the Jayhawks (rated 18th at KenPom have navigated a gauntlet schedule which includes four top-25 KenPom teams already.

The line movement tells the story: Kansas opened as 3.5-point favorites but that line has ballooned to -6.5, indicating sharp money recognizes the Jayhawks’ superior resume. This rivalry renewal tips-off at 1:00 pm ET and will be broadcast nationally on ESPN2.

Kansas vs Missouri Prediction & Best Bets

ATS Pick: Kansas -5.5 (-115) at DraftKings Missouri

This Border Showdown presents a textbook case of record versus resume. Missouri boasts a near-perfect record, the three-point line movement from Kansas -3.5 to -6.5 reflects sharp money recognizing the vast strength of schedule disparity. Missouri has feasted on inferior competition, with seven of nine opponents ranking outside KenPom’s top 200. Their lone loss came in their only game against a top-100 team, a pattern that screams regression.

Kansas has been forged in competitive fire, accumulating quality losses that will serve them well in this spot. The Jayhawks’ interior dominance, anchored by sophomore sensation Flory Bidunga, creates the game’s primary mismatch. Bidunga averages 15.2 points, 8.8 rebounds, and 2.6 blocks per game (14th nationally) while shooting an efficient 61.1% from the field. His rim protection will neutralize Missouri’s primary scoring threat Mark Mitchell (18.1 PPG), who has yet to face elite interior defense.

Kansas demonstrates superior ball security with a 1.36 assist-to-turnover ratio compared to Missouri’s 1.22, crucial in rivalry games where possessions become premium. The Jayhawks’ ability to execute against quality opposition, evidenced by their 3-3 record versus top-100 teams, far outweighs Missouri’s inflated statistics.

The Missouri vs Kansas spread is still as low as KU -5.5 at DraftKings, and that’s the best bet on the board currently.

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Game-Total Pick: Under 151.5 (-110) at FanDuel Missouri

The total presents equally compelling value, dropping as many as four points from its 154.5 opener to 151.5, which is classic reverse line movement indicating sharp action on the under. Like the spread, bettors can still find an more-inflated 151.5 O/U at FanDuel Missouri.

Rivalry games typically feature heightened defensive intensity, and this neutral-site atmosphere should amplify that tendency. Kansas’s shot-blocking presence, averaging 6.3 blocks per game compared to Missouri’s 3.0, will disrupt offensive rhythm. Meanwhile, Missouri’s Anthony Robinson II (2.4 steals, tied for 25th nationally) adds defensive chaos.

Kansas vs Missouri Closing Odds

The spread ranges from KU -5.5 to -6.5. DraftKings Missouri has the best number for Kansas bettors while bet365 Missouri has the best number for Tiger bettors. On the moneyline FanDuel Missouri has the best price on a Mizzou straight-up victory at +235, while – counter-intuitively – bet365 has the best price on a KU win at -270.

On the total, FanDuel has the best option for under bettors at 151.5 (-110) while DraftKings has the best option for over bettors at 149.5 (-112).

Odds and commentary as of 11:32 am ET. The lines in the table will update automatically with the best-available price for each market if the college basketball odds move before gametime.

Missouri vs Kansas Public Betting Trends

The college basketball public betting data demonstrate rare alignment, creating overwhelming support for Kansas despite their inferior record. Moneyline action shows 88.74% of bets backing the Jayhawks, while an even more significant 92.65% of total handle supports Kansas, indicating the largest wagers confidently favor the proven program.

Against the spread, 70.39% of tickets and 82.55% of money back Kansas to cover, reinforcing my ATS pick. This public-sharp consensus reflects widespread recognition of the strength of schedule advantage, with bettors buying Kansas’s battle-tested resume over Missouri’s inflated numbers.

The total sees similar clarity, with 58.82% of tickets and 58.28% of handle supporting the under.

Key Statistical Metrics: Kansas vs Missouri

The numbers reveal Missouri’s offensive explosion built against subpar competition, while Kansas has developed through superior opposition. This disparity contextualizes every statistical category and explains the market’s strong Kansas lean.