Opening 2025 NCAA Tournament Odds – UConn +1400 for March Madness Three-peat

• The 2025 March Madness odds have already been posted at online sportsbooks
• Duke, which has top recruit Cooper Flagg coming in, has opened as the betting favorite
• See the 2025 March Madness championship odds for the top 40 teams on the board

After back-to-back dominant championships by the UConn Huskies, the 2025 college basketball national championship odds have opened with eight teams between +1000 and +1800. While the Huskies are included in that bunch at +1400, it’s the Duke Blue Devils who have opened as the +1000 favorites to win the 2025 Men’s NCAA Tournament.

The table below lists the 2025 NCAA Tournament championship odds for the top 40 teams on the board.

2025 March Madness Champion Odds

The top team on the board that has never won a national title is Alabama (+1600), which reached its first-ever Final Four this season, losing to eventual-champion UConn.

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UConn Will Have Whole New Cast

It’s possible that Dan Hurley will have to replace all five of his starters. Tristen Newton and Cam Spencer are seniors (as is sixth man Hassan Diarra) while sophomore center Donovan Clingan and freshman guard Stephon Castle both project as lottery picks. Sophomore forward Alex Karaban is a likely second-round pick if he chooses to go pro.

Hurley has two top-100 recruits coming in and 6’10 junior Samson Johnson (5.4 PPG, 2.8 RPG) should adjust well to a starting role, but next year’s Huskies will be a completely different group than the one that romped to a second straight national championship. If Hurley is going to lead UConn to the first three-peat since early 70s UCLA, he’s going to do it the hard way.

I expect UConn to drop way down this list when the realities of roster turnover set in.

Duke Has Plenty of Variables

The Blue Devils will lose senior guard Jeremy Roach (14.0 PPG, 3.3 APG) are almost certain to lose stud freshman Jared McCain (14.3 PPG, 5.0 RPG) to the NBA, but it’s possible that leading scorer and rebounder Kyle Filipowski (16.4 PPG, 8.3 PPG) could return for his junior season. Same goes for freshman guard Caleb Foster (7.7 PPG, 40.6 3P%). And Jon Scheyer has the top-ranked recruit in the nation, 6’9 wing Cooper Flagg, joining the mix along with three other players in the top 25.

The Blue Devils went 29-7 and are coming off an impressive run to the Elite Eight. They finished the season rated seventh in adjusted efficiency at KenPom and were a rock-solid 21-14-1 against the spread in 2023-24. Their spot at the top of the board makes sense given how much the teams above them in the analytics will be losing. Duke’s odds are going to shift – one way or the other – when Filipowski makes his final draft decision.

Zags Will Be Running It Back

Gonzaga didn’t have a banner year, failing to win either the WCC regular-season or tournament championship. But the Zags did win 16 of their final 19 games and reached the Sweet 16 for the ninth straight season, where they bowed out to Purdue. They finished the year rated 12th at KenPom and eighth at Haslametrics. Their best regular-season win was an 89-85 victory at Rupp Arena over Kentucky, and they absolutely demolished Kansas (89-68) in the NCAA Tournament.

The only senior on their roster was forward Anton Watson (14.5 PPG, 7.1 RPG), the team’s second-leading scorer and rebounder. Barring unforeseen transfers, Mark Few should have the likes of Graham Ike, Ryan Nembhard, Nolan Hickman, Ben Huff, Ben Gregg, and Dusty Stromer back, which is a Final Four-calibre team.

Look for the Zags to start the season shorter than their current price of +2500.