Opening Houston vs Duke Odds – Spread, Moneyline & Total for Final Four

• The East #1 Duke Blue Devils will meet the Midwest #1 Houston Cougars in the Final Four next Saturday, April 5
• Duke, the top-rated and top-ranked team in the country, has opened as the betting favorite
• See the opening Houston vs Duke odds, including point spread, game total, and moneyline

The #1 Duke Blue Devils (35-3, 25-13 ATS, 20-18 O/U) cruised through the East Region with a 23.5-point average margin of victory, booking their ticket to San Antonio with an 85-65 rout of #2 Alabama on Saturday. On Sunday afternoon, the Midwest #1 Houston Cougars (34-4, 19-17-1 ATS, 15-21-1 OU) earned the right to meet Duke in the 2025 Final Four next Saturday, April 5, at the Alamodome. At the time of publication, Houston owned a 62-45 lead on #2 Tennessee with three minutes remaining. The opening Houston vs Duke odds favor the top-ranked Blue Devils reaching the championship game for the first time in a decade.

Houston vs Duke Odds

The Houston vs Duke spread has opened with the Blue Devils as sizable 5.5-point favorites and -215 chalk on the moneyline, amounting to a 68.25% implied win probability. The Cougars come back as +176 underdogs (36.23% implied win probability). The game total is 135.5 with -110 odds both ways

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Duke’s Road to the Final Four

The Blue Devils looked the part of the top team in the country throughout their first four games. After nearly doubling up on #16 Mount Saint Mary’s (94-49), Duke cruised past #9 Baylor (89-66) before bouncing #4 Arizona (100-93) in the Sweet 16 in a game that was not as close as the final score suggests. The Blue Devils led by double-digits from the 23-minute mark to the 36-minute mark and their win probability was over 90% for the entire second half.

Arguably their best performance of the tournament came last night against #2 Alabama. Duke held the prolific Crimson Tide, who had scored 80-plus in seven straight games and were averaging to just 65 points 94.3 PPG in the tournament, to just 65 points, their second-lowest output of the season.

Four of five starters scored at least 14 points, led by 21 from Kon Knueppel (14.4 PPG, 3.9 RPG, 2.8 APG). Cooper Flagg (18.9 PPG, 7.5 RPG, 4.2 APG), the favorite in the Wooden Award odds, added 16 points, nine rebounds, three assists, and a block.

Houston vs Duke Ratings Comparison

Ratings for Houston are from prior to their Elite Eight victory.

The storylines heading into San Antonio will be Duke’s top-rated offense against Houston’s top-rated defense. But don’t sleep on the opposite side for either team. KenPom rates Houston’s defense 12th in the nation, but it’s as high as fourth at Haslam. The Cougars have scored 72-plus points in six of their last seven games.

Duke, of course, had one of the best defensive performances of the tournament against Alabama. The Blue Devils currently sit fourth in D-Rating at both KenPom and Haslam.

Houston’s Path to the Final Four

The Cougars demolished #16 SIUE (78-40) before taking down #8 Gonzaga (81-76) in a game they controlled from the opening tip. Purdue, the #4 seed in the Midwest, was a trickier mistress in the Sweet 16. Houston had a comfortable 10-point lead with eight minutes remaining but a late Purdue flurry managed to tie the game at 60 with 35 seconds to play.

A genius inbound play from Kelvin Sampson’s group gave Houston a 62-60 win almost as time expired.

In the Elite Eight against #2 Tennessee, the Cougars looked the part of a #1 seed and the Big 12 regular-season and tournament champions; Houston raced out to a 31-12 lead and maintained that 19-point margin into halftime (34-15). Tennessee made a bit of a push in the final 20 minutes, trimming the lead to single-digits with just under five to play. But Houston’s lead was never seriously threatened.

Leading scorer LJ Cryer (15.3 PPG, 2.1 RPG, 2.0 APG) had a team-high 17 points with seven rebounds and four assists against the Vols,. Emmanuel Sharp (12.6 PPG, 3.0 RPG) added 16 points.