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Sweet 16 Odds – See Who’s Favored in All Eight Games

Sascha Paruk

By Sascha Paruk in College Basketball

Published:


St. John's Red Storm guard Dylan Darling celebrates his buzzer-beater vs Kansas
Mar 22, 2026; San Diego, CA, USA; St. John's Red Storm guard Dylan Darling (0) celebrates after defeating the Kansas Jayhawks in the second half during a second round game of the men's 2026 NCAA Tournament at Viejas Arena. Mandatory Credit: Denis Poroy-Imagn Images
  • The Sweet 16 odds have been posted for several matchups
  • Only one double-digit seed remains (#11 Texas) in a very chalky bracket
  • See the Sweet 16 odds for all eight games

The 2026 Sweet 16 will take place next Thursday and Friday (March 26 and 27) in Chicago, Houston, Philadelphia, and San Jose. The first matchups have been set and odds have been posted.

The table below lists the opening Sweet 16 odds for all games on the board so far. Others will be added as the matchups are set.

Sweet 16 Odds

TeamSpreadMLTotal
#3 Illinois+2.5 (-108)+130O 139.5 (-110)
#2 Houston-2.5 (-112)-155U 139.5 (-110)
TeamSpreadMLTotal
#11 Texas+8.5 (-110)+285O 149.5 (-110)
#2 Purdue-8.5 (-110)-360U 149.5 (-110)
TeamSpreadMLTotal
#5 St John’s+6.5 (-110)+210O 141.5 (-110)
#1 Duke-6.5 (-110)-258U 141.5 (-110)
TeamSpreadMLTotal
#6 Tennessee+3.5 (-102)+142O 138.5 (-115)
#2 Iowa State-3.5 (-120)-172U 138.5 (-105)
TeamSpreadMLTotal
#3 Michigan StateTBDTBDTBD
UCLA/UConnTBDTBDTBD
TeamSpreadMLTotal
#4 NebraskaTBDTBDTBD
Iowa/FloridaTBDTBDTBD
TeamSpreadMLTotal
#4 ArkansasTBDTBDTBD
Utah State/ArizonaTBDTBDTBD
TeamSpreadMLTotal
TBDTBDTBDTBD
#1 MichiganTBDTBDTBD

The biggest spread on the board so far is #2 Purdue laying 8.5 points against #11 Texas. The slimmest is Houston -2.5 against Illinois. Purdue/Texas also has the highest game total at 149.5.

Odds as of March 22nd at DraftKings and Kalshi. See which prediction markets are available in your region.

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#3 Illinois vs #2 Houston Betting Line

Prediction Markets
HOU vs ILL Odds
Learn more about Prediction Markets
Kalshi
Houston
58%
Illinois
43%

In the South Region, #3 Illinois will face #2 Houston for a spot in the Elite Eight. Despite two wildly impressive performances from Illinois (105-70 vs #14 Penn, 76-55 vs #11 VCU), the Illini are 2.5-point underdogs to the reigning national runners-up.

Houston ran over #15 Idaho (78-47) before overwhelming #10 Texas A&M (88-57).

#11Texas vs #2 Purdue Betting Line

Prediction Markets
TEX vs PUR Odds
Learn more about Prediction Markets
Kalshi
Purdue
76%
Texas
25%

Purdue’s red-hot March continued with double-digit wins over #15 Queens (104-71) and #7 Miami (79-69). Matt Painter’s team has now won six straight.

The Boilermakers get to face the only remaining double-digit seed: #11 Texas, which reached the Sweet 16 all the way from the First Four. The Longhorns beat fellow #11 NC State in Dayton before taking down #6 BYU (79-71) and #3 Gonzaga (74-68), all as underdogs.

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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