Texas Tech vs Iowa State Picks, Predictions & Betting Lines

• No. 4 Iowa State hosts No. 16 Texas Tech in a pivotal Big 12 matchup
• The Cyclones are heavy favorites as they continue to push for the No. 1 seed
• Read below for Texas Tech vs UIowa State picks, predictions and betting lines for Saturday afternoon

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The Iowa State Cyclones (24-4) and Texas Tech Raiders (21-7) will battle on Saturday afternoon in a Big 12 heavyweight clash. Tip-off is scheduled for 4:00 PM EST at James H. Hilton Coliseum on CBS.

Texas Tech has won five of their last six games after beating Cincinnati 80-68 on Tuesday. Iowa State secured a much-needed win against Utah after losing to BYU by double-digits last weekend. Our deep-dive analysis breaks down the key angles for this matchup.

Texas Tech vs Iowa State Picks & Predictions

The Red Raiders head into this game a 10.5-point underdog without their top performer. Can they pull off the upset?

Spread Pick: Iowa State -10.5 (-105 at DraftKings)

Texas Tech star forward JT Toppin was ruled out for the season ten days ago after suffering a torn ACL. Guard Christian Anderson has picked up the slack in his absence, averaging 26.0 points, 8.0 rebounds, and 8.5 assists in the two games without him. Those contributions are enough to handle teams Kansas State and Cincinnati, but they’ll need more firepower to keep up with Iowa State.

The raucous environment at the Coliseum won’t help either.

Player Prop Pick: Milan Momcilovic 16+ Points (-120 at DraftKings)

Momcilovic is Iowa State’s leading scorer and one of the nation’s best pure shooters. He averages 17.4 points per game and shoots an unconscious 50.7% from deep. He should have plenty of opportunities to score.

Texas Tech vs Iowa State Tale of the Tape

Key Mismatch: These teams are pretty even on paper, with Iowa State having the slight edge in offensive efficiency.

Texas Tech vs Iowa State Odds

• Moneyline: Texas Tech +470 | Iowa State -650
• Spread: Texas Tech +10.5 (-102) | Iowa State -13.5 (-118)
• Total: Over 145.5 (-105) | Under 145.5 (-115)

Odds as of February 28, 2026, at 11:30 AM ET from DraftKings Sportsbook.

Moneyline Payout Calculation

For bettors assessing the risk-reward ratio on a standard $20 wager:

• Betting Texas Tech (+470): Returns a profit of $94.00 (Total Payout: $114.00)
• Betting Iowa State (-650): Returns a profit of $3.08 (Total Payout: $23.08)

Texas Tech vs Iowa State Public-Betting Splits

The data from Saturday’s college basketball public betting percentages reveal confidence in Florida cruising over Ole Miss without much trouble.

Moneyline Splits

The market views Iowa State as a comfortable piece in a parlay, with the money following suit.

• Texas Tech Red Raiders: 5% of bets | 23% of money
• Iowa State Cyclones: 95% of bets | 77% of money

ATS Splits

The spread market highlights a belief that Texas Tech can keep the game close.

• Texas Tech Red Raiders: 62% of bets, 46% of money
• Iowa State Cyclones: 38% of bets, 54% of money

Total Market

The public is anticipating fireworks and respecting both offenses.

• Over 144.5: 85% of bets, 86% of money
• Under 144.5: 15% of bets, 14% of money

Texas Tech & Iowa State March Madness Odds

The fallout from this game will have heavy implications on the March Madness odds.

Texas Tech

• Open: +2500
• Now: +13000

Iowa State

• Now: +4500
• Open: 1700

How to Watch Texas Tech at Iowa State?

Viewers will be able to watch Texas Tech at Iowa State live on CBS.