Charlotte vs South Florida Prediction, Picks & Odds – Friday Night CFB

• Kick off your college football weekend Friday night when South Florida hosts Charlotte in an American Conference clash at 7 p.m. on ESPN2.
• The Bulls are big favorites against a Charlotte team that will have a new starter at quarterback.
• I have your Charlotte vs South Florida prediction and picks for Friday, along with a look at the latest odds

South Florida (3-1; 3-1 ATS) remains on the fringe of the Top 25 and is looking to impress voters when it hosts Charlotte (1-3; 1-3 ATS) Friday at Raymond James Stadium.

The Bulls opened the season with two wins over ranked teams, but were thumped by Miami in Week 3. South Florida leads the all-time series 2-0 and won by 35 points last year.

Charlotte is looking to spring an big upset, and I’ve got your Charlotte vs South Florida prediction, pick and look at the best odds for Friday.

Charlotte vs South Florida Prediction

South Florida was the talk of college football early on, after beating Boise State and Florida, but now we know that the Gators’ win wasn’t all that. South Florida had a chance to beat a third-ranked team when it faced Miami, but got dominated 42-13. They bounced back with a win over South Carolina State last week.

Charlotte is in full-scale rebuild under new coach Tim Albin, who came over after having success at Ohio University. Their only win is against an FCS squad, Monmouth, by a touchdown. Not that impressive.

Things got worse for the Miners last week in a 28-17 loss to Rice when starting quarterback Conner Harrell got knocked out with an injury. He’s out for the year. Charlotte has turned to Duke transfer Grayson Loftis behind center. The news got worse for South Florida, who also lost starting running back Henry Rutledge to an injury for the season.

Charlotte vs USF Picks

• South Florida -27.5 (-105 at BetMGM)

• Over 54.5 (-115 at BetMGM)

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I’m picking the Bulls to cover the spread and the over, knowing that each of South Florida’s last seven games as favorites have gone over the total.

South Florida has too much firepower for the Miners. Bulls QB Byrum Brown threw for four TDs last week against South Carolina State. Earlier this season, he had a streak of 252 passes without an interception. Bulls WR Chas Nimrod, a transfer from Tennessee, is averaging 26.2 yards a catch and will try to tie a school record with his third straight 100-yard game.

The Bulls will wear special helmets paying homage to their first season back in 1997. The Bulls are a contender in the American. Charlotte is not. Don’t overthink it. South Florida will roll.

Charlotte vs South Florida Odds

Odds as of Oct. 2 from BetMGM. Join the party at BetMGM with our BetMGM bonus code.

There has been some movement on the point spread before kickoff Friday. The spread was 26.5 at DraftKings early in the week, but it’s now 28.5 at DraftKings and FanDuel. It’s 27.5 at BetMGM. That one point is a big difference.

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Oddsmakers have the total at 55 at Bet365 and FanDuel. Its 54.5 at BetMGM. Both teams are 2-2 over/under this season. The best moneyline number is +2200 for Charlotte at FanDuel and -4500 for South Florida at Caesars.

South Florida has covered the spread easily in the first two meetings. They were 1.5-point favorites last year (won by 35) and 7-point favorites in 2023 (won by 34). The favorite has covered in Charlotte’s four games this season. The Miners have lost their last nine road openers.