Colorado vs Wyoming Prediction, Pick & Odds for Saturday Night Football

• We’ve made our Colorado vs Wyoming prediction for Week 4 Saturday night football on ESPN
• Colorado’s quarterback carousel continues with Kaidon Salter expected to return as starter
• Check out the Colorado vs Wyoming prediction, pick and odds for Saturday night football

Our Colorado vs Wyoming prediction for Saturday night’s Week 4 college football matchup on ESPN centers around Colorado’s ongoing quarterback drama as the Buffaloes host the Wyoming Cowboys for the late-window game.

The college football spreads have shifted toward Wyoming, with the line dropping from Colorado -13.5 to -11.5. Sharp money has backed the road dog all week.

Kickoff is set for 10:15pm ET from Folsom Field in Boulder, with ESPN providing the broadcast coverage.

Colorado vs Wyoming Prediction

• Pick: Wyoming +11.5 (-110 at Bet365)

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Colorado has no clue who their quarterback is. That’s not a recipe for covering double-digit spreads against anyone, let alone a disciplined Wyoming defense.

The line movement tells you everything. Sharp money pounded Wyoming from +13.5 down to +11.5, and there’s still value at the current number.

Wyoming’s stingy defense will keep them in this game and should feast on Colorado’s shaky offensive line. The Cowboys have the personnel to pressure whoever’s under center for the Buffs.

Colorado’s run defense is an absolute disaster. They’re giving up over 200 yards per game on the ground, and Sam Scott should have a field day. Wyoming will control the clock and shorten the game.

The altitude and extra day of rest favor Colorado, but those advantages are already baked into the line. Wyoming’s dealing with the elevation for just one game, not a full road swing.

The Under 45.5 also has value. Wyoming games have gone Under six straight times. Colorado can’t sustain drives with their quarterback shuffle, and Wyoming’s offense struggles to score consistently.

This shapes up as an ugly game where Wyoming hangs around all night. The Cowboys are 7-2 ATS in their last nine games overall. They’re also 4-1 ATS in their last five road games.

Colorado’s just 3-10-1 ATS as double-digit favorites in their last 14 tries. They don’t have the offensive firepower to pull away from anybody right now. I’m taking the points with Wyoming on Saturday night CFB.

Colorado vs Wyoming Odds

Colorado opened as 13.5-point favorites, but the market has moved decisively toward Wyoming. The total crept up slightly from 44.5 to 45.5 points.

The public betting splits show professional bettors pounding the Cowboys despite Colorado playing at home. When the sharps move a line two full points, it’s worth paying attention.

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Odds as of September 20 at 6 pm ET from Bet365. Be sure to check out the best Bet365 promo code before betting on Saturday night CFB.

Buffs Can’t Figure Out QB Situation

Colorado’s offense has been a complete mess this season. They’ve rotated three different quarterbacks through three games, and nobody’s taken control of the job.

Ryan Staub got the start last week at Houston and threw for 204 yards with one touchdown and two picks. His 54% completion rate wasn’t getting it done, so now Deion Sanders is switching back to Kaidon Salter.

Salter’s completing 68% of his passes but has managed just one touchdown through two games. He’s added 67 rushing yards and two scores on the ground, but the passing game remains stuck in neutral.

The quarterback chaos has infected the entire offense. Colorado ranks 95th in scoring at 23.7 points per game. They’re 105th in rushing with just 124 yards per contest.

The offensive line has been a turnstile. They’ve allowed nine sacks already and rank 108th nationally in line yards. That’s not going to improve against Wyoming’s aggressive front seven.

Making matters worse, the defense can’t stop anybody on the ground. They’re surrendering 204.3 rushing yards per game, ranking 124th nationally. Teams are averaging 4.7 yards per carry against them.

Wyoming Defense Travels Well

The Cowboys proved they could hang with quality competition last week. They held Utah to just three first-half points before eventually wearing down in a 31-6 loss.

Wyoming’s defense has been the story of their season. They’re allowing just 12.7 points per game and 313 total yards. The pass defense has been particularly impressive.

Opposing quarterbacks have managed just a 92.5 rating against the Cowboys. Wyoming’s allowing only 160 passing yards per game and less than five yards per attempt. They’ve recorded seven sacks through three games.

Coach Jay Sawvel knows his offense needs work. Kaden Anderson completed just 52% of his passes last week for 108 yards against Utah. The Cowboys managed just 229 total yards in that loss.

But they can lean on Sam Scott in the ground game. He’s averaging 67.7 yards per contest and should find room against Colorado’s porous run defense. If Wyoming can control the clock, they’ll keep this close.

The Under has cashed in six straight Wyoming games dating back to last season. Four of Colorado’s last five home games have also gone Under. This profiles as another defensive battle.