LSU vs Clemson Predictions, Player Props & Odds for Saturday’s Death Valley Showdown

• Cade Klubnik and Garrett Nussmeier duel in Death Valley showdown between No. 4 Clemson and No. 9 LSU
• Bryant Wesco has exceeded 54.5 receiving yards in six of his last 12 games
• Check out the latest LSU vs Clemson predictions, player props and odds for Saturday night

Two Heisman contenders collide Saturday night when Cade Klubnik and the No. 4 Clemson Tigers host Garrett Nussmeier and the No. 9 LSU Tigers in a primetime Death Valley showdown.

Both quarterbacks have legitimate first-round NFL Draft aspirations, but only one can emerge victorious in this Week 1 blockbuster. See my LSU vs Clemson predictions and player prop picks below.

LSU vs Clemson Prediction and Pick

• Final Pick: Under 55.5 (-110 at BetMGM)

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While everyone expects fireworks between these Heisman contenders, I’m betting on defense to rule the day. Both teams have elite defensive fronts that should disrupt the opposing offense.

Clemson’s Peter Woods and T.J. Parker form arguably the nation’s best defensive line duo. They’ll feast on LSU’s rebuilt offensive line that features only three returning starters. Nussmeier struggled under pressure last season, throwing 12 interceptions.

LSU’s defense, while not as talented, still returns eight starters, including linebacker Whit Weeks (120 tackles). First-game jitters in a hostile environment often lead to conservative playcalling and slower starts.

Brian Kelly is 0-3 in season openers at LSU, losing by an average of 13 points. Memorial Stadium’s crowd noise could force false starts and communication issues for the visitors.

I expect Clemson to win a defensive struggle, something like 27-20. The under has hit in four of Clemson’s last five games when facing ranked opponents. Take the under and enjoy what should be a classic defensive battle.

LSU vs Clemson Player Props

The Tigers are 4.5-point home favorites in the latest CFB odds. Garrett Nussmeier’s passing yardage prop is set at 283.5 yards, while Clemson wideout Bryant Wesco’s receiving yardage prop sits at 54.5 yards.

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Odds as of Aug. 30 at BetMGM Sportsbook. Explore the best betting apps for CFB player props.

LSU vs Clemson Prop Bet #1: Bryant Wesco Receiving Yards

Wesco emerged as Clemson’s premier deep threat last season, recording two touchdowns of 70-plus yards. The sophomore wideout exceeded this total in six of 12 games, including 61-plus yards in four of his final five contests.

LSU’s secondary ranked 76th against the pass and will be without starting safety AJ Haulcy for the first half due to suspension. The Bayou Bengals allowed 25 points per game last season and struggled to contain explosive plays.

With Klubnik’s improved touch on deep balls and Wesco’s elite speed, this presents outstanding value. The line seems low considering Wesco averaged 59 yards per game down the stretch last year.

• Pick: Bryant Wesco Over 54.5 Receiving Yards (-115)

LSU vs Clemson Prop Bet #2: Garrett Nussmeier Passing Yards

Nussmeier threw for 4,052 yards last season, but this line feels inflated against Clemson’s elite defense. The Tigers allowed just 213.5 passing yards per game and boasted a top-15 pressure rate.

LSU’s offensive line features only three returning starters and faces a Clemson pass rush anchored by potential first-rounders Peter Woods and T.J. Parker. Nussmeier absorbed 14 sacks over his final five SEC games last year.

In hostile road environments against ranked opponents, Nussmeier threw eight interceptions in four games. Expect LSU to lean more on their ground game early to protect their quarterback.

• Pick: Garrett Nussmeier Under 283.5 Passing Yards (-115)

LSU vs Clemson Prop Bet #3: Antonio Williams Anytime TD

Williams scored touchdowns in nine of 14 games last season, leading Clemson with 75 catches and 11 receiving touchdowns. At +100 odds, the implied probability is 50%, which undervalues a receiver who found the end zone regularly.

LSU allowed nearly 25 points per game and their linebacker corps may struggle covering Williams on crossing routes. He’s Klubnik’s most trusted target in the red zone.

These odds likely won’t be this short again all season. Williams is too talented and too involved in Clemson’s offense to pass up at this price.

• Pick: Antonio Williams Anytime Touchdown (-105 at BetMGM)

LSU vs Clemson Odds

The line has shifted a half-point toward Clemson in the last 24 hours, moving from -4 to -4.5. Clemson’s -200 moneyline implies a 66.7% probability of winning, while LSU’s +164 suggests a 37.9% chance of pulling the upset.

The total has recently dropped from 56.5 to 55.5, with sharp money on the under according to the college football public betting splits. Clemson has been a popular national championship pick based on Klubnik’s trajectory and NFL talent on defense.

Kickoff is set for 7:30pm ET from Memorial Stadium in Clemson, South Carolina, with ABC providing the broadcast coverage.