College Football Parlay Picks – Get +535 Odds for Saturday’s Week 0

• Our Week 0 college football parlay combines three confident picks at +535 odds
• We’re backing Iowa State with the points in Dublin against Kansas State
• Keep reading for our full CFB parlay picks for Week 0, including Hawaii and Fresno State

College football’s back, and there’s no better way to kick things off than with a Week 0 parlay paying +535 odds.

We’ve found three sharp plays for Saturday’s slate, including a bet on Iowa State catching points in the Aer Lingus Classic. Perfect timing for Kansas residents, too. Bet365 Kansas just went live, giving Jayhawks and Wildcats fans another option to get some action down.

Let’s break down our complete Week 0 CFB parlay, with each pick backed by solid data that’ll change how you see these games.

College Football Parlay Picks Week 0

Odds as of Thursday, August 22, at Bet365 Sportsbook. Build your own Week 0 parlay with the bet365 bonus code.

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This three-leg parlay delivers solid value at +535, capitalizing on what we see as soft lines in these season openers. Tail these picks at bet365 or shop around other college football betting apps to find your best number.

CFB Parlay Pick #1: Iowa State +3

Our Week 0 CFB parlay starts with the big showdown in Dublin.

Iowa State’s been owning this series. The Cyclones are 5-0 ATS over their last five meetings with Kansas State, capped by that 29-21 victory last November that sealed their first-ever 10-win season. Even their lone loss in that stretch? They still covered.

These trends aren’t fluky. Iowa State finished 8-6 ATS (57.1%) last year, consistently surpassing oddsmakers’ expectations. Kansas State, meanwhile, limped to just 4-9 ATS (30.8%), burning bettors most Saturdays.

ISU vs K-State Recent Series History

What really jumps out: Rocco Becht’s back after putting up 3,505 yards and 25 touchdowns last year. Iowa State’s defensive front has guys who can get after K-State’s revamped offensive line, potentially disrupting their rhythm early in this neutral-site game.

The Dublin location matters here. This is the tightest spread in Aer Lingus Classic history since 2016, when Boston College met Georgia Tech as basically equals. The oddsmakers see this as nearly a coin flip with a field goal tacked on.

Three points with a team that owns this matchup? We’ll take it every time.

• Pick: Iowa State +3 (-105)

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CFB Parlay Pick #2: Fresno State +14

Our Week 0 college football parlay continues, as Kansas debuts its renovated stadium against a Fresno State squad that lives in close games.

The Bulldogs have played 14 one-score contests the past two years – over half their games. Seven of their final eight games in 2024 went down to the wire. That comfort level in tight spots could be huge against a Kansas team that dropped five games by eight points or less last season.

Bulldogs vs Jayhawks: Close Game Experience

Matt Entz brings a ridiculous 60-11 career record from North Dakota State, plus two FCS titles. Sure, there are always questions with new coaches, but his defensive background should help keep this respectable.

Kansas plays slow. Really slow. They burned 28.8 seconds per snap last year (117th nationally) and averaged just 64.6 plays per game (109th). That grinding pace naturally keeps games tight.

The Jayhawks did convert an insane 50.7% of third downs – second-best in the country and fifth-highest for a Big 12 team since 2015. But here’s the catch: Fresno State’s defense allowed 32 drives of 10-plus plays, with opponents scoring on 22 of them. Something’s gotta give, and we think it stays close.

Two touchdowns in a season opener between teams with plenty of unknowns? That’s too many points.

• Pick: Fresno State +14 (-115)

CFB Parlay Pick #3: Hawaii ML (-135)

This one’s right there for the taking in Week 0 college football parlays.

Stanford’s a complete mess right now. They dumped Troy Taylor in March for off-field issues, then brought in Frank Reich as a one-year band-aid. It gets worse. The Cardinal watched their two best players on each side of the ball hit the portal, including game-changers Emmett Mosley and David Bailey.

The betting market’s already caught on. Stanford’s win total opened at just 3.5, and that might be generous. At +145 for the Over, books clearly expect another brutal year on The Farm.

Key Stanford vs Hawaii Stats

Timmy Chang’s got Hawaii heading in the right direction. The Rainbow Warriors bring back 14 starters, led by Micah Alejado, who torched New Mexico for 469 yards and five TDs in the season finale.

Pofele Ashlock and Nick Cenacle return at receiver. Ashlock’s averaging a crazy 6.0 catches per game, which is the most among active FBS players with 10-plus games. Both receivers posted six-plus touchdown grabs and 30-plus first downs last year.

Stanford’s defense? Historically awful. They’ve given up at least one passing touchdown in 28 straight games and allowed 400-plus total yards for eight straight seasons. That’s the longest active streak in the country.

The CFB line movement tells the whole story. Stanford opened as a small favorite, but smart money completely flipped it. Hawaii’s now laying 2.5, and we’ll happily grab them on the moneyline for parlay value.

• Pick: Hawaii ML (-135)