Opening College Football Week 12 Odds, Spreads & Early Predictions 2025

• The Week 12 college football odds have been posted at online sportsbooks
• Week 12 features four ranked-on-ranked games
• See the college football Week 12 odds for all power-conference and top-25 teams

Another Saturday is in the books and oddsmakers have already posted the college football Week 12 odds for Nov. 15th, 2025. The Week 12 slate includes a massive tilt between #11 Texas and #5 Georgia in Athens, along with three other ranked-on-ranked games (based on last week’s top 25): #20 Iowa vs #19 USC, #12 Oklahoma vs #4 Alabama, and #10 Notre Dame vs #24 Pitt.

The table below sets out the college football Week 12 odds for all games involving power-conference teams and top-25 teams. Under the table, find my favorite Week 12 lines to target early.

College Football Week 12 Odds

Based on last week’s rankings, the Week 12 schedule includes four ranked-on-ranked games, headlined by #11 Texas vs #5 Georgia, where the Bulldogs have opened as 6.5-point home favorites. In Tuscaloosa, #4 Alabama has opened as a touchdown-favorite against #12 Oklahoma.

The top-two teams in the country both have cupcake matchups, unfortunately: #1 Ohio State is a 31.5-point home favorite against UCLA, while #2 Indiana is a 30.5-point home favorite against Wisconsin. The Buckeyes and Hoosiers remain the favorites in the national championship odds. Ohio State is the +200 outright favorite, while Indiana ranges from +500 to +600. Texas A&M (+700 to +750) overtook Alabama (+700 to +800) as the third-favorite ahead of Week 12.

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Early Week 12 Pick: Pitt (+10.5) vs Notre Dame

Since dropping back-to-back games in Weeks 3 and 4 (31-24 at WVU and 34-27 vs Louisville), Pitt has rattled off five straight wins in impressive fashion, going 5-0 ATS in that span. After a 35-20 win at Stanford in Week 11 as 13.5-point road chalk, the Panthers have now covered the spread in all seven wins this season. Their 7-2 ATS record is tied for fifth-best out of all 136 DI teams.

Notre Dame has an identical 7-2 SU record and has won seven straight after a stunning 0-2 start to the season. All seven wins have come by at least ten points, but this will be their first road game against a ranked team since Week 1, when they fell 27-24 at Miami.

Pitt has scored at least 24 points in every game this season and sits eighth in the nation in scoring, averaging 39.7 PPG. Notre Dame’s defense is good (19.9 PPG) and has undoubtedly been improving over the course of the season, but elite offenses have been able to move the ball: Texas A&M put up 41 and Miami scored 27. It’s hard to distance an offense as good as Pitt’s on the road.