Week 4 College Football Parlay: Expert CFB Picks at +610 Odds

By Brady Trettenero in College Football
Published:

- My Saturday college football parlay hits three different betting markets
- My top spread, moneyline, and total picks combine for +610 odds
- See expert CFB parlay picks targeting sharp money movement and home underdog value
Saturday’s Week 4 college football slate is packed with betting value, and I’ve built a three-leg college football parlay at +610 odds that combines multiple markets. My expert CFB picks take into account sharp line moves, home-field advantage, and matchup edges.
These aren’t chalk plays. We’re mixing a home underdog moneyline, a spread with massive line movement, and a total ready to explode. Here’s my top college football parlay for Saturday.
College Football Parlay Week 4
All odds as of September 19th, at Bet365 Sportsbook. Create your own CFB Week 4 parlay with a Bet365 bonus code.

SPORTSBOOK
These parlay picks provide excellent value at +610 odds. We’re hitting the moneyline, spread, and total markets with three plays that each carry their own edge.
CFB Parlay Picks: Nebraska Moneyline
I’m backing the Cornhuskers as home underdogs against Michigan on Saturday afternoon. This game has upset potential written all over it.
Dylan Raiola has been perfect through three weeks, completing 79.3% of his passes without throwing an interception. That 9-to-0 touchdown-to-interception ratio says it all. Now he gets his first real test in front of a fired-up home crowd.
Michigan will be without head coach Sherrone Moore, who’s suspended. That’s a major blow heading into a Big Ten road game. Nebraska is rolling on offense, averaging 49 points with a +41 point differential. Those are their best numbers since 1995.
Meanwhile, Michigan struggled in its only road game, losing at Oklahoma with a rough quarterback outing from freshman Bryce Underwood. He went just 9-of-24 passing in that one.
The line has shifted toward Nebraska, and sharp money continues to back them. Lincoln remains one of the toughest places to play in college football. The combination of Raiola’s hot hand, Michigan’s coaching situation, and home-field advantage makes Nebraska a smart upset pick.
- College Football Pick: Nebraska ML -105
College Football Parlay Picks: UTEP Spread
For my spread pick, I’m taking UTEP as 6.5-point favorites at home against Louisiana-Monroe. The line movement tells you everything you need to know here.
UTEP opened as just 1.5-point favorites before sharp money pounded this line up to -6.5. Five full points of movement doesn’t happen by accident. When professionals identify this kind of edge, they attack it hard.
The matchup in the trenches favors UTEP drastically. Their pass rush has collected 10 sacks and 14 QB hits through three games. They’re going against Louisiana-Monroe’s one-dimensional offense that averages just 89.0 passing yards per game, ranking 133rd nationally.
The Warhawks rely entirely on their rushing attack, averaging 202 yards per game. But UTEP’s run defense has been rock solid, allowing just 143.0 yards per game at 3.3 yards per carry. Once the Miners shut down ULM’s ground game, the Warhawks face obvious passing situations against a relentless pass rush.
Weather adds another layer to this handicap. Rain and wind are forecasted for El Paso, which only compounds Louisiana-Monroe’s passing game problems. Bad weather, a dominant pass rush, and no passing attack should equal a comfortable UTEP victory.
- CFB Pick: UTEP -6.5 -110
CFB Parlay Picks: Northern Illinois/Mississippi State Over
To wrap up this college football parlay, I’m taking the over in Northern Illinois vs Mississippi State. The Bulldogs’ offense creates the perfect storm for points.
Mississippi State has been explosive through three games, averaging over 40 points per contest. Blake Shapen runs an efficient offense that attacks defenses multiple ways. The trend supports this play too – the Bulldogs have hit the over in six of their last seven home games.
Northern Illinois brings a defense allowing 18.5 points per game, but they haven’t faced SEC-level talent. Mississippi State operates with more speed and skill than anything the Huskies have seen this season.
The key matchup comes up front. Mississippi State’s offensive line posts elite pass-block grades while allowing just four sacks through three games. Northern Illinois has managed only two sacks all season. Shapen will have clean pockets all afternoon to dissect an overmatched NIU secondary.
Game script helps push this over too. Once Mississippi State builds an early lead, NIU must abandon their run-heavy approach and throw to keep pace. While the Huskies offense has struggled at 14 points per game, garbage time production should help this total clear 48.5.
- CFB Pick: NIU vs MSU Over 48.5 -110
This three-leg college football parlay brings value from different angles. There’s a home underdog with real upside, a spread supported by sharp line movement, and a total boosted by strong offenses and a favorable matchup. At +610 odds, these picks offer great value for Saturday.
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Lead NHL & NCAAF Editor
Brady is the lead NHL and College Football editor at Sports Betting Dime, where he specializes in betting odds and data-driven analysis. Brady has over 10 years experience working in sports media, with work published by outlets such as ESPN, CBS Sports, Yahoo! Sports and Fox Sports.