Computer Picks for Opening Day – A.I. Best Bets for All 11 MLB Games

• Our A.I. model has made its Opening Day picks for Saturday, March 26
• See the top computer pick for all 11 MLB games today

And, now, Part II of Opening Day …

The Yankees opened the 2026 MLB season by blanking San Francisco 7-0 on Wednesday night.

Today, 22 more teams partake in Opening Day, starting with 2025 NL Cy Young Award winner Paul Skenes, whose Pirates take on the Mets at Citi Field.

I asked Sportradar’s proprietary A.I. model to generate its best spread bet for all 11 games. The table summarizes the picks, which I line-shopped across all available sportsbooks.

A.I. MLB Picks & Computer Predictions

5 Best Bets for Opening Day (March 26)

1. Los Angeles Dodgers -1.5 (-125 at DraftKings): The defending World Series champion Dodgers boast significant firepower and match up exceptionally well against Arizona. Yoshinobu Yamamoto — Skenes’ top challenger in NL Cy Young Awards odds — gets the nod after going 12-8 with a 2.49 ERA last season. The Dodgers’ offensive prowess is well-documented, led by four-time league MVP Shohei Ohtani.

2. Milwaukee Brewers -1.5 (+110 at BetMGM): Jacob Misiorowski, a 2025 call-up who became a key force in Milwaukee’s playoff push last season, gets the Opening Day nod against the visiting White Sox. Misiorowski won 2 playoff games last season.The Brewers offer substantial value laying the 1.5 runs against a White Sox team projected to struggle to generate runs.

3. Houston Astros -1.5 (+115 at DraftKings): The Astros present a massive mismatch at home against the Angels. Early market handle heavily targets Houston as sharp money pours in on the home favorite. Expect the Astros’ deep lineup to separate late and comfortably cover the run line at plus-money.

4. Baltimore Orioles -1.5 (+135 at DraftKings): Pete Alonso is set to make his Orioles today. Baltimore’s offense makes it an attractive plus-money option on the run line. Minnesota’s Joe Ryan (13-10, 3.42 ERA last year) makes his second career Opening Day start, but he Orioles have the necessary tools to stretch a lead and secure a multi-run victory in front of their home crowd.

5. Chicago Cubs -1.5 (-105 at Caesars): Chicago carries a strong 67.5% implied win probability against Washington, making the Cubs an excellent candidate to chase Opening Day starter Cade Cavalli and win by multiple runs. Cavailli made his MLB debut in 2022, then had Tommy John surgery and didn’t return to the majors until last season. The Cubs’ balanced attack and favorable pitching matchup put them in a prime position to handle the Nationals.