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Opening Cubs vs Brewers NLDS Odds, Series Price & Schedule

Sascha Paruk

By Sascha Paruk in MLB Baseball

Published:


Milwaukee Brewers right fielder Sal Frelick crosses home plate against the Chicago Cubs
Aug 21, 2025; Chicago, Illinois, USA; Milwaukee Brewers right fielder Sal Frelick (10) scores against the Chicago Cubs during the eight inning at Wrigley Field. Mandatory Credit: Kamil Krzaczynski-Imagn Images
  • NL Central rivals meet in the NLDS when as the Cubs face the Brewers
  • The Cubs were one of the few teams with a winning record against the MLB-best Brewers
  • See the Chicago Cubs vs Milwaukee Brewers odds for the NLDS plus series schedule

The Chicago Cubs (92-70, 52-32 home, 42-39 away) punched their ticket to the 2025 NLDS with a 3-1 win over San Diego, and will now face the MLB-best Milwaukee Brewers (97-65, 52-29 home, 45-36 away) in an all-NL Central best-of-five series.

The Cubs went 7-6 against Milwaukee in the regular season, and were one of just four NL teams with a winning record against the league leaders. But Milwaukee has opened as a sizable favorite in the Cubs vs Brewers NLDS odds.

Chicago Cubs vs Milwaukee Brewers NLDS Odds

MarketCHCMIL
Series Price+100-116
Series SpreadTBDTBD
Total Games O 4.5 (+160)U 4.5 (-190)

Milwaukee has opened as a -116 favorite with the Cubs coming back as +100 underdogs. The opening series price gives the Brewers a 53.70% win probability, compared to 50% for Chicago.

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Odds as of Oct. 2 at FanDuel.

Despite going an MLB-best 97-65 in the regular season, the Brewers are only the fifth-favorite in the World Series odds at +725, trailing the Dodgers, Phillies, Mariners, and Blue Jays. The Cubs’ odds improved from +1300 to +750 after their Game 3 win over the Padres.

CHC vs MIL Regular-Season Results

Date (Location)ScoreML ResultO/U Result
May 2 (MIL)10-0 CHC-121O 9.0
May 3 (MIL)6-2 CHC-118U 8.5
May 4 (MIL)4-0 MIL-105U 8.0
Jun 17 (CHI)5-3 CHC-147U 9.5
Jun 19 (CHI)8-7 MIL-125O 8.5
Jul 28 (MIL)8-4 MIL-103O 7.5
Jul 29 (MIL)9-3 MIL-126O 8.0
Jul 30 (MIL)10-3 CHC+110O 7.0
Aug 18 (CHI)7-0 MIL+103U 8.0
Aug 19 (CHI)6-4 CHC-151O 7.0
Aug 19 (CHI)4-1 CHC+111U 6.5
Aug 20 (CHI)4-3 CHC-103P 7.0
Aug 21 (CHI)4-1 MIL+128U 6.5

The Cubs managed a 3-3 split in Milwaukee during the regular season, and took four of seven at Wrigley Field. The Cubs outscored the Brewers 60-56 over the 13 regular-season games.

CHC vs MIL NLDS Schedule

GameDateLocation
1Sat, Oct 4Milwaukee
2Mon, Oct 6Milwaukee
3Wed, Oct 8Chicago
4Thu, Oct 9Chicago
5Sat, Oct 11Milwaukee

The series will open on Saturday, October 4th, at American Family Field in Milwaukee. The teams will have Sunday off before Game 2 on Monday, also in Milwaukee. The series will shift to Chicago for Games 3 and (if necessary) 4 on Wednesday and Thursday (October 8th and 9th).

If there’s a Game 5, it will be back in Milwaukee on Saturday, October 11th.

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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