MLB Opening Day Picks & Odds for All 15 Games
- MLB Opening Day is set for Thursday, March 28th
- Brewers vs Mets kicks off the 15-game slate, while Yankees vs Astros highlights the afternoon action
- Read below for full MLB Opening Day picks and odds for 2024
MLB Opening Day is almost here, with 30 teams scheduled to kick off the season on Thursday, March 28th. MLB odds have been released for the massive 15-game slate that begins with Brewers vs Mets and concludes with Red Sox vs Mariners.
We’ve made our MLB Opening Day predictions, including identifying the games with the best betting value. Below, you can see a full table of game odds and our expert picks.
MLB Opening Day Odds 2024
| Matchup | Run Line | Moneyline | Total |
|---|---|---|---|
| Milwaukee Brewers | -1.5 (+154) | -110 | O 7.5 (-110) |
| New York Mets | +1.5 (-185) | -110 | U 7.5 (-112) |
| Matchup | Run Line | Moneyline | Total |
| Atlanta Braves | -1.5 (+136) | -162 | O 7.5 (-110) |
| Philadelphia Phillies | +1.5 (-162) | +105 | U 7.5 (-110) |
| Matchup | Run Line | Moneyline | Total |
| Los Angeles Angels | +1.5 (-135) | +154 | O 8 (-102) |
| Baltimore Orioles | -1.5 (+114) | -185 | U 8 (-118) |
| Matchup | Run Line | Moneyline | Total |
| St. Louis Cardinals | +1.5 (-102) | +190 | O 8.5 (-120) |
| Los Angeles Dodgers | -1.5 (-118) | -230 | U 8.5 (+100) |
| Matchup | Run Line | Moneyline | Total |
| New York Yankees | +1.5 (+130 | +130 | O 8.5 (-115) |
| Houston Astros | -1.5 (-155) | -155 | U 8.5 (-105) |
| Matchup | Run Line | Moneyline | Total |
| Pittsburgh Pirates | +1.5 (-192) | +160 | O 7.5 (-115) |
| Miami Marlins | -1.5 (+160) | -192 | U 7.5 (-105) |
| Matchup | Run Line | Moneyline | Total |
| Detroit Tigers | -1.5 (-108) | -180 | O 7.5 (-102) |
| Chicago White Sox | +1.5 (-112) | +150 | U 7.5 (-118) |
| Matchup | Run Line | Moneyline | Total |
| Toronto Blue Blue Jays | +1.5 (-185) | +114 | O 7.5 (-115) |
| Tampa Bay Rays | -1.5 (+154) | -135 | U 7.5 (-105) |
| Matchup | Run Line | Moneyline | Total |
| Washington Nationals | +1.5 (-162) | +130 | O 9 (+100) |
| Cincinnati Reds | -1.5 (+136) | -155 | U 9 (-120) |
| Matchup | Run Line | Moneyline | Total |
| Minnesota Twins | -1.5 (+140) | -120 | O 8 (+100) |
| Kansas City Royals | +1.5 (-166) | +100 | U 8 (-120) |
| Matchup | Run Line | Moneyline | Total |
| San Fransisco Giants | -1.5 (+160) | -108 | O 7.5 (-110) |
| San Diego Padres | +1.5 (-192) | -112 | U 7.5 (-110) |
| Matchup | Run Line | Moneyline | Total |
| Chicago Cubs | -1.5 (+160) | -105 | O 8 (-118) |
| Texas Rangers | +1.5 (-192) | -115 | U 8 (-102) |
| Matchup | Run Line | Moneyline | Total |
| Cleveland Guardians | -1.5 (+114) | -162 | O 7.5 (+100) |
| Oakland Athletics | +1.5 (-135) | +136 | U 7.5 (-120) |
| Matchup | Run Line | Moneyline | Total |
| Colorado Rockies | +1.5 (-105) | +200 | O 8.5 (-110) |
| Arizona Diamondbacks | -1.5 (-115) | -245 | U 8.5 (-110) |
| Matchup | Run Line | Moneyline | Total |
| Boston Red Sox | +1.5 (-148) | +145 | O 7.5 (-112) |
| Seattle Mariners | -1.5 (+124) | -175 | U 7.5 (-108) |
In the MLB Opening Day odds for 2024, the heaviest favorite on the board is the Arizona Diamondbacks (-235) in their late-night matchup with the Colorado Rockies. Conversely, the tightest line is an afternoon clash between the San Francisco Giants (-108) and San Diego Padres (-112).
When it comes to game totals, the Washington Nationals vs Cincinnati Reds matchup is the only game that features a total of 9 or higher. Make sure to check out our MLB odds page for the latest markets as these prices can change
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Brewers vs Mets Prediction & Pick
The very first pitch of the 2024 season features an intriguing contrast of styles, as the small-market Brewers visit the big-spending Mets in Queens. 20-year-old phenom Jackson Chourio, the consensus top prospect in baseball, headlines Milwaukee’s youth movement. He’ll make his highly anticipated MLB debut as part of a Brewers lineup looking to prove the doubters wrong.
They’ll have their work cut out for them against Mets veteran José Quintana. The crafty lefty stabilized New York’s rotation after coming over at last year’s trade deadline. On the other side, Brewers ace Freddy Peralta looks to build off a breakout 2023 campaign and stake his claim as one of the NL’s elite arms.
Your SP1 is @FreddyPeraltaRD ❕❕❕ pic.twitter.com/IcxfkGdcLu
— Milwaukee Brewers (@Brewers) March 19, 2024
While the Mets opened as the favorites on paper, don’t be surprised if the plucky Brewers play spoiler behind a strong Peralta outing and some Opening Day magic from their dynamic rookie Chourio. In 11 career innings vs NYM, Peralta has only conceded four runs.
Furthermore, Francisco Lindor, Ketel Marte, and Pete Alonso are only a combined 1 for 18 against Peralta. In a season where many expect Milwaukee to take a step back, an upset win over the mighty Mets would send an early message that they’re still a force to be reckoned with in the NL Central.
MLB Opening Day Pick:
- Milwaukee Brewers ML (-110)
Editors Note: This game has been postponed until Friday due to inclement weather.
Yankees vs Astros Best Bet
A rematch of the epic 2022 ALCS, the Yankees and Astros waste no time renewing their budding rivalry. Offseason acquisition Juan Soto makes his highly anticipated Yankees debut, joining a fearsome lineup with Aaron Judge, Giancarlo Stanton and Anthony Rizzo.
They’ll face a tall task against Astros ace Framber Valdez, who led the AL with a 2.82 ERA in 2023. The Astros, who have won two World Series titles in four years, still boast a potent offense led by Yordan Alvarez, Kyle Tucker, and Jose Altuve. Yankees southpaw Nestor Cortes will try to keep them in check.
Nestor drops down a bit to get Olson to end the 1st! pic.twitter.com/vrPGYyndnh
— Talkin' Yanks (@TalkinYanks) March 21, 2024
But in a matchup between two evenly matched powerhouses, the Astros’ championship pedigree gives them a slight edge. The Astros took the season series 5-2 last year, with the Yankees 29th-ranked batting average proving costly.
Cortes struggled in spring training, going 0-2 with a 7.71 ERA. Look for Valdez to outduel Cortes in a low-scoring pitcher’s duel as the Astros begin their World Series quest with a hard-fought victory.
MLB Opening Day Picks:
- Astros ML (-155)
- Under 8.5 Runs (-105)
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Brady is the lead NHL and College Football editor at Sports Betting Dime, where he specializes in betting odds and data-driven analysis. Brady has over 10 years experience working in sports media, with work published by outlets such as ESPN, CBS Sports, Yahoo! Sports and Fox Sports.
