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MLB Opening Day Picks & Odds for All 15 Games

Brady Trettenero

by Brady Trettenero in MLB Baseball

Updated Mar 28, 2024 · 9:15 AM PDT

Milwaukee Brewers starting pitcher Freddy Peralta throws
Mar 9, 2024; Phoenix, Arizona, USA; Milwaukee Brewers starting pitcher Freddy Peralta (51) throws against the Seattle Mariners in the first inning at American Family Fields of Phoenix. Mandatory Credit: Rick Scuteri-USA TODAY Sports
  • MLB Opening Day is set for Thursday, March 28th
  • Brewers vs Mets kicks off the 15-game slate, while Yankees vs Astros highlights the afternoon action
  • Read below for full MLB Opening Day picks and odds for 2024

MLB Opening Day is almost here, with 30 teams scheduled to kick off the season on Thursday, March 28th. MLB odds have been released for the massive 15-game slate that begins with Brewers vs Mets and concludes with Red Sox vs Mariners.

We’ve made our MLB Opening Day predictions, including identifying the games with the best betting value. Below, you can see a full table of game odds and our expert picks.

MLB Opening Day Odds 2024

Matchup Run Line Moneyline Total
Milwaukee Brewers -1.5 (+154) -110 O 7.5 (-110)
New York Mets +1.5 (-185) -110 U 7.5 (-112)
Matchup Run Line Moneyline Total
Atlanta Braves -1.5 (+136) -162 O 7.5 (-110)
Philadelphia Phillies +1.5 (-162) +105 U 7.5 (-110)
Matchup Run Line Moneyline Total
Los Angeles Angels +1.5 (-135) +154 O 8 (-102)
Baltimore Orioles -1.5 (+114) -185 U 8 (-118)
Matchup Run Line Moneyline Total
St. Louis Cardinals +1.5 (-102) +190 O 8.5 (-120)
Los Angeles Dodgers -1.5 (-118) -230 U 8.5 (+100)
Matchup Run Line Moneyline Total
New York Yankees +1.5 (+130 +130 O 8.5 (-115)
Houston Astros -1.5 (-155) -155 U 8.5 (-105)
Matchup Run Line Moneyline Total
Pittsburgh Pirates +1.5 (-192) +160 O 7.5 (-115)
Miami Marlins -1.5 (+160) -192 U 7.5 (-105)
Matchup Run Line Moneyline Total
Detroit Tigers -1.5 (-108) -180 O 7.5 (-102)
Chicago White Sox +1.5 (-112) +150 U 7.5 (-118)
Matchup Run Line Moneyline Total
Toronto Blue Blue Jays +1.5 (-185) +114 O 7.5 (-115)
Tampa Bay Rays -1.5 (+154) -135 U 7.5 (-105)
Matchup Run Line Moneyline Total
Washington Nationals +1.5 (-162) +130 O 9 (+100)
Cincinnati Reds -1.5 (+136) -155 U 9 (-120)
Matchup Run Line Moneyline Total
Minnesota Twins -1.5 (+140) -120 O 8 (+100)
Kansas City Royals +1.5 (-166) +100 U 8 (-120)
Matchup Run Line Moneyline Total
San Fransisco Giants -1.5 (+160) -108 O 7.5 (-110)
San Diego Padres +1.5 (-192) -112 U 7.5 (-110)
Matchup Run Line Moneyline Total
Chicago Cubs -1.5 (+160) -105 O 8 (-118)
Texas Rangers +1.5 (-192) -115 U 8 (-102)
Matchup Run Line Moneyline Total
Cleveland Guardians -1.5 (+114) -162 O 7.5 (+100)
Oakland Athletics +1.5 (-135) +136 U 7.5 (-120)
Matchup Run Line Moneyline Total
Colorado Rockies +1.5 (-105) +200 O 8.5 (-110)
Arizona Diamondbacks -1.5 (-115) -245 U 8.5 (-110)
Matchup Run Line Moneyline Total
Boston Red Sox +1.5 (-148) +145 O 7.5 (-112)
Seattle Mariners -1.5 (+124) -175 U 7.5 (-108)

In the MLB Opening Day odds for 2024, the heaviest favorite on the board is the Arizona Diamondbacks (-235) in their late-night matchup with the Colorado Rockies. Conversely, the tightest line is an afternoon clash between the San Francisco Giants (-108) and San Diego Padres (-112).

When it comes to game totals, the Washington Nationals vs Cincinnati Reds matchup is the only game that features a total of 9 or higher. Make sure to check out our MLB odds page for the latest markets as these prices can change



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Brewers vs Mets Prediction & Pick

The very first pitch of the 2024 season features an intriguing contrast of styles, as the small-market Brewers visit the big-spending Mets in Queens. 20-year-old phenom Jackson Chourio, the consensus top prospect in baseball, headlines Milwaukee’s youth movement. He’ll make his highly anticipated MLB debut as part of a Brewers lineup looking to prove the doubters wrong.

They’ll have their work cut out for them against Mets veteran José Quintana. The crafty lefty stabilized New York’s rotation after coming over at last year’s trade deadline. On the other side, Brewers ace Freddy Peralta looks to build off a breakout 2023 campaign and stake his claim as one of the NL’s elite arms.

While the Mets opened as the favorites on paper, don’t be surprised if the plucky Brewers play spoiler behind a strong Peralta outing and some Opening Day magic from their dynamic rookie Chourio. In 11 career innings vs NYM, Peralta has only conceded four runs.

Furthermore, Francisco Lindor, Ketel Marte, and Pete Alonso are only a combined 1 for 18 against Peralta. In a season where many expect Milwaukee to take a step back, an upset win over the mighty Mets would send an early message that they’re still a force to be reckoned with in the NL Central.

MLB Opening Day Pick:

  • Milwaukee Brewers ML (-110)

Editors Note: This game has been postponed until Friday due to inclement weather.

Yankees vs Astros Best Bet

A rematch of the epic 2022 ALCS, the Yankees and Astros waste no time renewing their budding rivalry. Offseason acquisition Juan Soto makes his highly anticipated Yankees debut, joining a fearsome lineup with Aaron Judge, Giancarlo Stanton and Anthony Rizzo.

They’ll face a tall task against Astros ace Framber Valdez, who led the AL with a 2.82 ERA in 2023. The Astros, who have won two World Series titles in four years, still boast a potent offense led by Yordan Alvarez, Kyle Tucker, and Jose Altuve. Yankees southpaw Nestor Cortes will try to keep them in check.

But in a matchup between two evenly matched powerhouses, the Astros’ championship pedigree gives them a slight edge. The Astros took the season series 5-2 last year, with the Yankees 29th-ranked batting average proving costly.

Cortes struggled in spring training, going 0-2 with a 7.71 ERA. Look for Valdez to outduel Cortes in a low-scoring pitcher’s duel as the Astros begin their World Series quest with a hard-fought victory.

MLB Opening Day Picks:

  • Astros ML (-155)
  • Under 8.5 Runs (-105)

Make sure you check out the best sports betting apps for MLB before placing your bets! Several sign-up offers are available for new customers ahead of Opening Day.

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