Cavaliers vs Pacers Series Odds & Schedule, Plus Game 1 Spread, Total & Moneyline

• The #1 Cleveland Cavaliers will face the #4 Indiana Pacers in the second round of the 2025 NBA playoffs
• Indiana was the only team to beat Cleveland three times in the regular season (3-1 SU)
• See the opening Cavaliers vs Pacers series odds plus the Game 1 spread, moneyline, and total

The #4 Indiana Pacers (50-32, 29-11 home, 20-20 away) have booked their ticket to the second round of the NBA playoff bracket and will now face the #1 Cleveland Cavaliers (64-18, 34-7 home, 30-11 away) in a best-of-seven for the right to advance to the 2025 Eastern Conference Final. Though Indiana had success against Cleveland in the regular season – more on that later – the Cavaliers vs Pacers series odds heavily favor Cleveland advancing, and without much fuss.

CLE Cavaliers vs IND Pacers Series Odds

The Cavs have opened as -460 favorites to win the best-of-seven series and are -168 favorites to do so by multiple games. The O/U on total games has been set at 5.5 with the -128.

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Indiana was one of just six teams to beat Cleveland on its home court this season, along with Atlanta, Houston, Boston, Orlando, and Sacramento. The Pacers were the only team to do it twice, and were also the only team to beat Cleveland three times overall.

But take that with a grain of salt. The teams split a pair of home-and-home games on Jan. 12 and 14, with each winning on the other’s court. Then the Pacers won a pair of late-season games in which the Cavs were missing/resting a boatload of starters and rotation players.

CLE vs IND Regular-Season Results

So, in the table above, only the January games actually featured the anything resembling the rosters that will meet in the playoffs.

Indiana’s five-game first-round series win over the #5 Milwaukee Bucks featured three over and two unders. The Pacers covered the spread in their first three wins but needed a miraculous OT comeback to seal a one-point victory in the series-clinching Game 5 on Tuesday night (119-118).

Cleveland absolutely embarrassed the #8 Miami Heat during a four-game first-round sweep. They won every game by at least nine points and by an average of 30.5 PPG. That included a 37-point win in Game 3 and a laughable 55-point win in Game 4, both on Miami’s home court. Three of the four games hit the over.

Pacers vs Cavs Game 1 Odds

The NBA odds already list the Game 1 spread, total, and moneyline, and they heavily favor Cleveland to take the early lead in the best-of-seven series. The Cavaliers have opened as 7.5-point favorites to win Game 1, which will take place at Rocket Mortgage FieldHouse in Cleveland on Sunday, May 4 (start time TDB).

On the moneyline, Cleveland is -310 to take a 1-0 series lead, while the Pacers are +250 road underdogs. The game total is sitting at .5 with -110 odds each way.

Cleveland Cavaliers vs Indiana Pacers Series Schedule

*If necessary.