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Ohio State vs Indiana Odds, Spread and Pick

Chris Amberley

by Chris Amberley in College Football

Oct 20, 2021 · 9:00 AM PDT

C.J. Stroud drops back to pass
Ohio State quarterback C.J. Stroud plays against Maryland during an NCAA college football game Saturday, Oct. 9, 2021, in Columbus, Ohio. (AP Photo/Jay LaPrete)
  • #5 Ohio State is a 20-point road favorite over Indiana on Saturday (October 23rd, 7:30 pm ET) at Memorial Stadium, in Bloomington, IN
  • The Buckeyes are averaging 8.55 yards per play, and 4.12 points per drive on offense
  • Read below for odds, analysis and a betting prediction

Thanks to Iowa’s stunning loss to Purdue in Week 7, Ohio State is once again the highest ranked Big Ten program. The Buckeyes (5-1, 3-0 Big Ten) jumped one spot to #5 in the AP Poll, despite having the week off. They’ll resume their schedule on Saturday (October 23rd), as a heavy road favorite over Indiana (2-4, 0-3 Big Ten).

#5 Ohio State vs Indiana Odds

Team Moneyline Spread Total
Ohio State Buckeyes -1125 -20 (-110) O 60 (-110)
Indiana Hoosiers +700 +20 (-110) U 60 (-110)

Odds as of  Oct. 19th at DraftKings.

Ohio State is currently laying 20 points, in a game that features a total of 60. Kickoff is scheduled for 7:30 pm ET at Memorial Stadium in Bloomington, with ABC providing the coverage. A chilly night for football is on tap, as the temperature is expected to dip to 48 degrees in the evening.


States: CT, PA, NJ, IA IN, IL, CO, MI, TN, VA, WV, AZ


Ohio State’s Offense On Fire

Since dropping its second game of the season, the Buckeyes have been stomping opponents. They’ve won each of their last four games by 21 points or more, while operating at a higher efficiency than any team in program history.

Ohio State is currently averaging 8.55 yards per play, 1.26 yards more than their previous best mark over a full season. Their 4.12 points per drive average ranks second in the nation, while their 0.77 points per play is better than each of the past two National Champions.

Redshirt QB C.J. Stroud is leading the charge, racking up absurd numbers over his past two starts. Stroud threw for 736 yards and 10 TD combined versus Rutgers and Maryland, putting up a passer rating north of 225 in each outing.

Whether you look at QBR or EPA (expected points added), he’s the top ranked quarterback in the country. He’s not the only Buckeye with eye popping statistics however. Running back TreVeyon Henderson is averaging 8.74 yards per carry, and has already found the end zone 11 times.

The matchup with Indiana is not one to fear, in fact it’s quite favorable. The Hoosiers rank 13th in the Big Ten in scoring defense, and have been outscored by 57 points in three conference games so far.

Indiana Ice Cold

Indiana enters Week 8 winless in Big Ten play, and 0-4 versus ranked competition. To their credit, all four losses have come against current top-11 programs, but only one of the contests has been decided by fewer than 14 points.

That result came last week versus #9 Michigan State, but the Hoosiers were derailed by a lifeless offense. QB Jack Tuttle, starting in place of the inured Michael Penix, turned the ball over three times, including this pick-six in the opening quarter.

Tuttle finished with only 188 passing yards in the 20-15 loss, and with no timetable for Penix’s return, Tuttle is expected to start again versus OSU. Indiana ranks 11th in the conference in scoring, and will be hard pressed to muster much offense against the revamped Buckeyes defense.

Ohio State overhauled the entire unit, including play-calling duties, following Week 3, and have since held opponents to only 12.3 points per game. They rank 21st in defensive efficiency per SP+, up 17 spots from their season low ranking after Week 2.

Ohio State vs Indiana Pick

I’m not one that usually advocates laying 20 points on the road, but this Buckeyes team is operating at another level right now. They’ve outscored their opposition by 140 points over the last three games alone, and have already covered spreads of 48.5 and 22 points this season.

It also doesn’t hurt that they’ve beaten the Hoosiers 25 straight times. Four of the last five matchups have beed decided by 21 points or more, including each of the past two in Indiana.

The Hoosiers meanwhile, are 1-5 ATS this season, and 0-4 ATS versus ranked teams.

Pick: Ohio State -20 (-110)

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