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Opening NFL Week 2 Odds, Lines and Spreads

Robert Duff

by Robert Duff in NFL Football

Sep 12, 2021 · 7:24 PM PDT

Ben Roethlisberger celebration
Pittsburgh Steelers quarterback Ben Roethlisberger (7) begins to celebrate as time runs out in a 23-16 Steelers win over the Buffalo Bills in an NFL football game in Orchard Park, N.Y., Sunday, Sept. 12, 2021. (AP Photo/Adrian Kraus)
  • Week 2 of the NFL season kicks off on Thursday Night Football (Sept. 16th) as Washington hosts the Giants
  • The Buccaneers are the slate’s biggest favorite at -12.5 over the Falcons
  • See below for all the Week 2 opening lines and spreads

One week into the NFL season, here’s what we know:

Expectations appear to be weighing heavily on the Buffalo Bills and Cleveland Browns. And the NFC West? It really is all that.

Both the Bills and Browns, considered to hold solid potential to be AFC Super Bowl representatives, fell in Week 1. Each squandered leads in doing so. The Browns were up 22-10 on the two-time defending AFC champion Kansas City Chiefs and lost 33-29. In Buffalo, the Bills held a 10-0 lead at the half and lost 23-16 to the Pittsburgh Steelers.

Meanwhile, NFC West teams were crushing it all over the place. San Francisco put up 41 points at Detroit. Arizona scored 38 at Tennessee and Seattle was good for 28 points at Indianapolis. With his first pass as quarterback of the Los Angeles Rams, Matthew Stafford threw a 67-yard TD.

NFL Week 2 Opening Odds

Team Moneyline Spread Total
New York Giants +185 +4.5 (-110) O 42.5 (-110)
Washington Football Team -225 -4.5 (-110) U 42.5 (-110)
Team Moneyline Spread Total
New Orleans Saints -180 -3 (-110) O 46 (-110)
Carolina Panthers +155 +3 (-110) U 46 (-110)
Team Moneyline Spread Total
Cincinnati Bengals +145 +3 (-110) O 45.5 (-110)
Chicago Bears -120 -3 (-110) U 45.5 (-110)
Team Moneyline Spread Total
Houston Texans +500 +11.5 (-110) O 48 (-110)
Cleveland Browns -720 -11.5 (-110) U 48 (-110)
Team Moneyline Spread Total
Los Angeles Rams -210 -4 (-110) O 47 (-110)
Indianapolis Colts +175 +4 (-110) U 47 (-110)
Team Moneyline Spread Total
Denver Broncos -275 -6 (-110) O 44 (-110)
Jacksonville Jaguars +220 +6 (-110) U 44 (-110)
Team Moneyline Spread Total
Buffalo Bills -190 -3.5 (-105) O 47.5 (-110)
Miami Dolphins +160 +3.5 (-115) U 47.5 (-110)
Team Moneyline Spread Total
New England Patriots -200 -3.5 (-115) O 43 (-110)
New York Jets +170 +3.5 (-105) U 43 (-110)
Team Moneyline Spread Total
San Francisco 49ers -170 -3 (-115) O 49 (-110)
Philadelphia Eagles +150 +3 (-105) U 49 (-110)
Team Moneyline Spread Total
Las Vegas Raiders +205 +6 (-115) O 49 (-110)
Pittsburgh Steelers -255 -6 (-105) U 49 (-110)
Team Moneyline Spread Total
Minnesota Vikings +175 +4 (-105) O 51 (-110)
Arizona Cardinals -210 -4 (-115) U 51 (-110)
Team Moneyline Spread Total
Atlanta Falcons +550 +12.5 (-105) O 52.5 (-110)
Tampa Bay Buccaneers -800 -12.5 (-115) U 52.5 (-110)
Team Moneyline Spread Total
Dallas Cowboys +130 +2.5 (-105) O 52.5 (-110)
Los Angeles Chargers -150 -2.5 (-115) U 52.5 (-110)
Team Moneyline Spread Total
Tennessee Titans +225 +3 (-110) O 52.5 (-110)
Seattle Seahawks -280 -3 (-110) U 52.5 (-110)
Team Moneyline Spread Total
Kansas City Chiefs -145 -2.5 (-110) O 55.5 (-110)
Baltimore Ravens +125 +2.5 (-110) U 55.5 (-110)
Team Moneyline Spread Total
Detroit Lions +410 +10.5 (-110) O 49.5 (-110)
Green Bay Packers -575 -10.5 (-110) U 49.5 (-110)

Odds as of September 12th at DraftKings.

Let’s look at some of the intriguing betting lines in the NFL odds heading into Week 2 of the NFL season. The Chiefs face yet another difficult AFC North opponent in the Baltimore Ravens. KC has been given the shortest betting line of any favorite at -2.5. This game has also been assigned the week’s highest total of 55.5 points.

Meanwhile, the reigning Super Bowl champion Tampa Bay Buccaneers are a whopping 12.5-point pick over the Atlanta Falcons. That’s the largest spread of any Week 2 game.

Oddsmakers aren’t expecting much scoreboard action in the NFC matchup between the Washington Football Team and New York Giants. This game has been assigned the smallest total of the week at 42.5 points, with good reason. Washington has a smothering defense, while Ryan Fitzpatrick, QB for the WFT, is out with a hip injury.

Shrinking Bucs Spread Won’t Stop Here

The point spread on the Tampa Bay-Atlanta game of Buccaneers -13 was barely up when it was shortened to Tampa Bay -12.5. Atlanta was dreadfully thrashed 32-6 in Week 1 by a Philadelphia Eagles team that went 4-11-1 last season.

Nonetheless, this is the NFL. There’s no cupcakes on the schedule. Last week, the Bucs kicked off as a 9-point choice over the Dallas Cowboys, 6-10 a year ago, and won by two points. Expect the Tampa Bay-Atlanta line to continue to shorten.

Overrating The Steelers

As they opened 11-0 last season, there was growing speculation that the Pittsburgh Steelers weren’t as impressive as their record indicated. A 1-5 conclusion to the season verified those suspicions.

People may also be reading too much into that Week 1 triumph at Buffalo. Pittsburgh garnered just 252 yards of net offense against the Bills. The difference on the scoreboard was a special teams TD from a blocked punt.

The Raiders are kryptonite to the Steelers. They’ve won five of seven from Pittsburgh. The last four and five of the past six Steelers-Raiders games were decided by exactly a field goal.

Look for there to be plenty of action on the Raiders, causing this line to shorten.

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