49ers vs Eagles Picks, Predictions, Injury Reports for Wild Card Sunday

• The Eagles’ quest to repeat as Super Bowl champs starts with a Wild Card game against the 49ers
• San Francisco has been hammered by injuries, leading to the odds shifting towards Philadelphia
• See my top 49ers vs Eagles predictions and picks, plus the latest odds and injury reports

Two NFC powerhouses collide in the Wild Card Round, as the San Francisco 49ers (12-5, 7-2 away, 11-6 ATS) travel to face the Philadelphia Eagles (11-6, 5-3 home, 10-7 ATS). The Eagles captured the NFC East division title and earned home-field advantage, while the 49ers secured a Wild-Card berth despite finishing third in the stacked NFC West.

The contest kicks off at 4:30 pm ET from Lincoln Financial Field, with FOX providing the broadcast coverage. Light rain/mist are forecast for kickoff along with moderate crosswinds, potentially adding another wrinkle to this physical postseason battle. Below, I have set out my 49ers vs Eagles picks and strongest value plays along with the latest San Francisco/Philadelphia Wild Card odds and the injury reports, which look much worse for the Niners than the Eagles.

Jump to: PICKS || ODDS || SPLITS || INJURY REPORTS

49ers vs Eagles Predictions & Top Betting Picks

The Eagles enter as significant home favorites, but the betting value strongly favors the visiting 49ers in this Wild Card showdown. The spread has ballooned from an opening number of 3.5 points to a full six points, creating substantial value on a talented San Francisco squad that compiled a superior regular-season record and rates better in multiple analytics. My analysis points toward a grinding, defensive-minded affair where the 49ers’ offensive versatility keeps them within striking distance throughout.

ATS Pick: San Francisco 49ers +6 (-107) at BetRivers

The line movement from -3.5 to -6.0 represents a classic overreaction to home-field advantage and big-name injuries. San Francisco possesses the offensive weapons to exploit Philadelphia’s defensive vulnerabilities. Christian McCaffrey’s dual-threat ability allows the 49ers to control game flow through both rushing and receiving, while George Kittle provides a reliable security blanket in crucial down-and-distance situations.

The 49ers out-ranked the Eagles in both overall DVOA (10th vs 13th) and EPA per play (8th vs 16th) during the regular season. Having both Fred Warner and Nick Bosa on the IR entering the postseason is far from ideal, but the Niners still have a solid if not star-studded defense, and they are catching way too many points today.

Game-Total Pick: Under 44.5 (-110) at BetMGM

Sharp money has driven this total down two full points from its opening mark of 46.5, signaling professional backing for a lower-scoring playoff grind. The market adjustment aligns with historical Wild Card trends, where defensive intensity typically increases and offensive efficiency decreases. The under movement – and an under bet at the lower number of 44.5 – are also supported by the weather forecast, which includes moderate crosswinds and wet football that will make deep passes difficult.

Best Player Prop: Brock Purdy Under 229.5 Pass Yards (-115) at BetMGM

Purdy’s passing-yards line has dropped steeply at most sportsbooks after opening at 235.5. It’s now as low as 212.5 at BetRivers. Yet BetMGM is still offering -115 odds on under 229.5, which is only a modest five-yard decrease from the soft opening number.

The adjustment reflects expectations for a run-heavy game script where San Francisco leans on Christian McCaffrey to control possession and limit Philadelphia’s offensive opportunities. It’s also likely based on bettors recognizing the difficulty of connecting on deep passes in the wet and windy weather conditions at the Linc.

Latest 49ers vs Eagles Odds & Betting Lines

The 49ers vs Eagles point spread has grown from an opening line of just 2.5 all the way to PHI -5.5 or 6.0, depending on the sportsbook. The Eagles moneyline has shorted to a market-best -270 from the opening -146 number. BetMGM has the best moneyline odds on a San Francisco upset (+225) while bet365 has the best ML price on an Eagles win.

The total has dropped two full points from 46.5 to 44.5.

Based on vig-free probability calculations, the Eagles carry approximately 70.0% implied win probability, while the 49ers hold just 30.0%.

Odds as of 11:13 am ET, Jan. 11th. Download the best football betting apps for the 2026 NFL playoffs.

SF vs PHI Public Betting Splits

The NFL public betting splits show a fascinating dichotomy between confidence in an Eagles’ win and skepticism about their ability to cover the inflated spread. Money distribution reveals sharp disagreement with the inflated line, particularly on the point spread where contrarian value has emerged.

Key Market Movements:

• Moneyline: 52.07% of total handle backs the 49ers at +220 odds, indicating larger wagers on the upset
• Spread: An overwhelming 80.19% of money is on San Francisco +6, showing near-unanimous rejection of the inflated line
• Total: Public sentiment favors scoring with 63.2% of handle on Over 44.5, contrasting sharply with the line’s downward movement

The spread distribution represents one of the most lopsided betting patterns of Wild Card weekend, with recreational and sharp bettors alike questioning whether Philadelphia can win by a touchdown against a team that posted a better regular season record.

49ers vs Eagles Injury Reports

Both teams enter the playoff opener with manageable injury concerns, though several key contributors remain questionable. The Niners have already listed defensive anchor Fred Warner on IR, along with Nick Bosa.

Niners vs Eagles Player-Prop Comparison

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