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A.I. NFL Picks for Week 12 – ATS and O/U Predictions for Each Game

Sascha Paruk

By Sascha Paruk in NFL News

Published:


Buffalo Bills running back James Cook carrying the ball
Buffalo Bills running back James Cook III runs with the ball after catching a short pass from quarterback Josh Allen during second half action against the Tampa Bay Buccaneers on Nov 16, 2025 at Highmark Stadium in Orchard Park.
  • Our A.I. has made its NFL Week 12 picks, including an ATS and O/U prediction for each game
  • I suggest fading the A.I. on both fronts as its 61-74 ATS and 58-77 O/U this season
  • See the A.I. NFL picks for all Week 12 games

Our internal A.I. put in another ugly performance last week, going 4-10 ATS and 7-7 O/U heading into tonight’s MNF game between the Cowboys and Raiders (where it has Dallas -3.0 and under 50.5).

I have already generated its Week 12 ATS and O/U picks for all 14 games on the slate. The table below sets out its NFL picks for Week 12.

A.I. NFL Week 12 Picks

MatchupATS PickO/U Pick
BUF Bills vs HOU TexansBills -3.5 (Underdog)Under 44.5 (Underdog)
MIN Vikings vs GB PackersPackers -5.5 (Underdog)Under 43.5 (Underdog)
IND Colts vs KC ChiefsColts +4.5 (Underdog)Over 48.5 (DraftKings)
NE Patriots vs CIN BengalsPatriots -5.5 (Underdog)Under 50.5 (DraftKings)
PIT Steelers vs CHI BearsBears -2.5 (Underdog)Over 44.5 (FanDuel)
NY Jets vs BAL RavensRavens -14 (bet365)Under 44.5 (Underdog)
NY Giants vs DET LionsLions -10.5 (bet365)Over 48.5 (Underdog)
SEA Seahawks vs TEN TitansSeahawks -12.5 (Underdog)Under 43.5 (Underdog)
JAX Jaguars vs ARI CardinalsJaguars -0.5 (Underdog)Under 48.5 (ESPN)
CLE Browns vs LV RaidersBrowns +3 (Caesars)Under 37.5 (Underdog)
PHI Eagles vs DAL CowboysCowboys +4.5 (Caesars)Over 50.5 (BetMGM)
ATL Falcons vs NO SaintsFalcons -1.0 (bet365)Under 41.5 (Underdog)
TB Buccaneers vs LA RamsRams -6.5 (Underdog)Over 49.5 (Underdog)
CAR Panthers vs SF 49ers49ers -6.5 (bet365)Under 48.0 (bet365)

The A.I. is heavy on chalk in Week 12, taking 11 ATS favorites and just three underdogs (Cowboys +3.5 vs Eagles, Browns +3 at Raiders, and Colts +3.5 at Chiefs).

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  • A.I. ATS Record: 61-74
  • A.I. O/U Record: 58-77

A.I. 0-10 ATS on Eagles Games

One pick I would lock in now is Eagles (-4.5) at Dallas. The A.I. has not hit a single Eagles game against the spread this entire season, going a stunning 0-10 after the first 11 weeks.

That’s insane. Your chances of losing 11 straight coin flips are 0.0488%.

It’s become safe to assume that the A.I. is relying on some faulty assumptions when it comes to the Birds.

A.I. 10-1 ATS on Patriots Games

At the opposite end of the spectrum is the A.I.’s performance on New England games. The A.I. has a bonkers 10-1 ATS record on Patriots games this season, going 8-0 to start the season before losing Patriots -4.5 against the Falcons in Week 9. But it bounced back with Patriots +2.5 at the Buccaneers in Week 10 and Patriots -11.5 vs the Jets in Week 11.

In Week 12, the A.I. is backing New England -5.5 at the reeling Bengals in Cincinnati.

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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