A.I. NFL Player Props & Picks for Week 10 – One A.I. Prop Bet from Each Game

• I have generated our A.I.’s NFL player-prop picks from all Week 10 games
• The A.I. is 47-39 on the season (+2.86) units and is coming off a 9-4 performance last week
• See the top A.I. NFL prop picks for Week 10

Our A.I. is coming off a brilliant performance last week when it went 9-4 on its NFL player-prop picks, profiting just over three units on one-unit wagers. It’s now back in the black for the season as a whole (+2.86 units) and is eight picks above .500 (47-39).

Can it keep the momentum going in Week 10? There is only one way to find out, so I have asked our A.I. to provide its top player-prop pick from each of the 14 games this week.

The table below sets out its prop pick for every game (minus three games which don’t have sufficient NFL player props posted yet), alongside the best available NFL odds at legal online sportsbooks.

A.I. NFL Player Prop Picks for Week 10

The A.I. has targeted its first to kicker props of the season, picking a Chad Ryland (Arizona) and Eddie Pineiro (San Francisco) both to go over 1.5 field goals. It’s also found four separate QBs that it likes to go over 1.5 TD passes (and one it likes to stay under).

Best odds as of 2:39 pm ET, November 5th. MO residents can bookmark SBD’s page on Missouri betting apps to see the latest offers and sign-up promos before launch in December.

LV vs DEN Player Prop to Bet: Nix Over 1.5 Passing TDs

Rationale: “All signs point to another strong showing from the Broncos’ QB. Bo Nix has been a different player at Mile High, and his recent success isn’t an anomaly. He has thrown for more than 1.5 touchdowns in 5 of his last 6 games in Denver, averaging an impressive 2.7 touchdowns per game over that span.”

ATL vs IND Player Prop to Bet: Jones Over 12.5 Rushing Yards

Rationale: “While Jonathan Taylor rightly commands the defensive focus, Daniel Jones has consistently used his legs to move the chains, and this prop line is simply too low given his history. Jones has gone over 15.5 rushing yards in 11 of his last 12 games when the Colts are favored by fewer than 7 points. This line is as high as 15.5 yards at some sportsbooks. Getting it at 12.5 with minimal juice is excellent value.”

BAL vs MIN Player Prop to Bet: Jackson Over 1.5 Passing Touchdowns

Rationale: “This represents the premier prop bet of the slate. Jackson’s touchdown production has reached elite consistency, and the underlying metrics provide compelling justification for backing his aerial scoring ability. He has thrown for more than 1.5 touchdowns in 11 of his last 12 games (91.7% success rate) and averages an impressive 2.7 passing touchdowns per game over that 12-game span. Minnesota’s offense averages 22.2 points per game, providing enough firepower to keep this game competitive and force Baltimore to maintain an aggressive passing approach. Against a Vikings defense that ranks in the bottom third in scoring defense, Jackson should find multiple opportunities to reach the end zone through the air.”

NE vs TB Player Prop to Bet: Mayfield Over 1.5 Passing TDs

Rationale: “The market has Mayfield’s touchdown line at 1.5, and the trends suggest the over represents the strongest play on the board. Mayfield has been on an absolute tear when facing quality opposition, especially at Raymond James Stadium, and the data overwhelmingly supports another multi-touchdown performance against the 7-2 Patriots. Mayfield has thrown for over 1.5 touchdowns in 9 of his last 10 games against teams with a winning record, establishing a dominant 90% hit rate. The trend becomes even more pronounced at Raymond James Stadium, where he has surpassed this mark in 8 straight games against winning teams.”

JAX vs HOU Player Prop to Bet: Lawrence Under 1.5 Passing TDs

Rationale: “The case against a multi-touchdown performance from Lawrence builds on extensive historical data against this specific opponent. His struggles represent a consistent pattern rather than recent variance. Lawrence has failed to throw for two or more touchdowns in 7 of his last 8 games against the division-rival Texans. He has also stayed under this line in 5 of his last 6 games overall, averaging just 0.8 passing scores per contest. Against top-10 scoring defenses, Lawrence is a perfect 5-for-5 to the under on this prop this year.”

CLE vs NYJ Player Prop to Bet: TBD

Rationale: TBD

NO vs CAR Player Prop to Bet: Young Under 187.5 Passing Yards

Rationale: “Young has failed to surpass 178.5 passing yards in four straight games against the Saints, averaging a meager 155.5 yards per contest in those matchups. His season average of 173.8 passing yards per game already sits below this prop line, showing this isn’t an outlier but a consistent pattern of limited production.”

NYG vs CHI Player Prop to Bet: Dart Under 220.5 Passing Yards

Rationale: “Multiple factors converge to create exceptional value on Dart’s passing under. The rookie faces a hostile road environment where New York has consistently faltered, losing their last 10 straight away from home. Dart has failed to exceed 220.5 passing yards in five of his first six starts, averaging just 195.8 YPG.”

BUF vs MIA Player Prop to Bet: Achane Over 58.5 Rushing Yards

Rationale: “Achane has been on a tear, exceeding 62.5 rushing yards in four straight games. His current prop line sits lower at 58.5 yards, offering a slight cushion. He is the engine of Miami’s response after a defeat. In his last four games following a loss, Achane has cleared this rushing mark each time, averaging an explosive 94.0 yards per game.”

ARI vs SEA Player Prop to Bet: Ryland Over 1.5 Field Goals

Rationale: “The most compelling prop on the board is backing Arizona’s kicker to have a busy afternoon. At even money, this bet aligns perfectly with the Cardinals’ offensive identity this season. Arizona has proven adept at sustaining drives, converting on an impressive 45.9% of their third-down attempts. However, this efficiency wanes inside the opponent’s 20-yard line. The Cardinals’ offense scores a touchdown on only 58.1% of its red-zone trips. This tendency to bog down in scoring territory is the ideal setup for field-goal opportunities. Ryland has hit 88.2% of his kicks this season and gone over 1.5 field goals in seven of his last ten road games.”

LAR vs SF Player Prop to Bet: Pineiro Over 1.5 Field Goals

Rationale: “Here we find excellent value on a prop that aligns perfectly with the 49ers’ offensive profile. San Francisco’s offense is proficient at moving the ball but has a tendency to settle for field goals, reflected in their relatively modest 56.7% red zone touchdown conversion rate. Kicker Eddy Pineiro has been nearly automatic for the team, providing a reliable source of points when drives stall, going 20 of 22 this season. Oddsmakers have juiced the under on his extra points prop (2.5 at -154), signaling a belief that the 49ers will struggle to find the end zone multiple times. If San Francisco’s offense moves the ball between the 20s but fails to convert in the red area—a common theme this season—Pineiro will be called upon multiple times. At near even money, this is a strong bet on the continuation of a season-long trend.”

DET vs WSH Player Prop to Bet: TBD

Rationale: TBD

PIT vs LAC Player Prop to Bet: TBD

Rationale: TBD

PHI vs GB Player Prop to Bet: Hurts Over 1.5 Passing TDs

Rationale: “The market has set Jalen Hurts’ passing yardage line suspiciously low at 191.5, suggesting a run-heavy game plan. However, his touchdown prop offers tremendous value, especially at plus-money. The Eagles are the most efficient red-zone offense in football, converting 85.0% of their attempts into points. This efficiency creates a wealth of scoring opportunities. The trends overwhelmingly support Hurts finding the end zone through the air multiple times: Hurts has thrown for more than 1.5 touchdowns in five of his last six games; he has been exceptional against top-tier opponents, clearing this line in six consecutive games against top-10 scoring defenses, averaging 2.3 TDs in those contests; he has also thrown for over 1.5 TDs in four straight games following a win, averaging 2.8 TDs.”