NFL Picks & Early Line Movement for Week 2

• The NFL Week 2 odds have already been out for nearly 48 hours
• One game total has already moved by three full points
• See the NFL Week 2 odds and line movement, plus my favorite early NFL Week 2 picks

The NFL Week 2 odds came out on Sunday night, which means the public and sharps alike have had nearly two full days to get early money in.

Per usual, the NFL odds have seen considerable movement in the first 36 hours. The point spread has moved by two points.

The table below lists the current NFL Week 2 odds, juxtaposed against the opening lines. Opening spreads, moneylines, and totals are in parentheses. Under the table, find my two NFL ATS and O/U picks to target.

NFL Week 2 Odds & Line Movement

The biggest spread on the board, by 5.5 points, is from the Browns vs Ravens game in Baltimore, where the hometown Ravens are still laying 12.5 points (same as the opening number).

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Bookmark SBD’s NFL public betting page to see the money percentages for every game of the season.

NFL Week 2 Pick #1: Raiders vs Chargers Under 47.5

This total has absolutely exploded from an opening number of 44.5 to 47.5 as of Tuesday morning. Both the Raider and Charger offenses look improved compared to last season. Geno Smith passed for 362 yards in his first game in a Las Vegas uniform, connecting with burgeoning superstar tight end Brock Bowers for five catches and 103 yards.

But the Ashton Jeanty-led run game stagnated (38 yards on 19 carries for Jeanty, who remains the favorite in the Offensive Rookie of the Year odds) and the Las Vegas defense looked much-improved, holding New England to just 13 points and 60 rush yards while generating four sacks and an INT.

The Charger defense was solid in Brazil against Patrick Mahomes and the Chiefs. LAC held Mahomes to a subpar 61.5% completion rate and just one TD in a 27-21 victory over their AFC West rivals. That unit is not going to allow Geno Smith to throw for another 350-plus yards.

I see the Chargers holding the Raiders to 17 points or fewer, which would necessitate 30-plus from the LAC offense to go over the new total of 47.5. This O/U has moved too high.

NFL Week 2 Pick #2: 49ers (-4.5) vs Saints

My second pick is another public fade. The Niners opened as 6.5-point road favorites against the Saints, who rank dead-last in the NFL Power Rankings ahead of Week 2. That line has already dropped two full points to San Francisco -4.5, largely due to starting QB Brock Purdy suffering multiple injuries (toe/shoulder) during Week 1.

Purdy is officially questionable for Week 2 on the preliminary injury report. Former Patriot/Jaguar Mac Jones (the #15 pick in the 2021 draft) sits behind Purdy on the depth chart.

Purdy wasn’t the only Niner star to get injured in Week 1, either. All-Pro tight end George Kittle is expected to miss three to five weeks with a hamstring injury, while WR1 Jauan Jennings is questionable with a shoulder injury.

The good news for the Niners is that Christian McCaffrey is healthy and the defense remains intact. San Francisco won and covered at Seattle in Week 1 (17-13 win as 2.5-point road favorites) thanks to its D. The Niners held Seattle to a miniscule 230 yards and 13 points, overcoming two interceptions from Purdy.

The Saints, meanwhile, could only must 13 points at home against an Arizona defense that allowed 25.8 PPG on the road last season. Spencer Rattler managed just 214 passing yards despite throwing 46 passes (4.65 YPA).

The New Orleans defense was gashed for 146 yards on the ground by Trey Benson and company.

The NOLA defense did generate five sacks, but that’s the only positive coming out of Week 1 for a Saints team that’s currently favored to get the #1 pick in the 2026 draft.

The 49er defense alone should keep this spread relatively high.