Chiefs vs Giants Prediction, Picks & Betting Lines for Sunday Night Football

• The Chiefs are 6-point road favorites over the Giants on Sunday Night Football in Week 3
• Both teams enter winless at 0-2, making this a desperation game to avoid 0-3
• See my Chiefs vs Giants prediction and picks below, plus the latest betting odds for Sunday Night Football

Two winless teams meet under the Sunday Night Football lights in a matchup nobody saw coming. The Chiefs (0-2, 0-0 away) and Giants (0-2, 0-2 home) both face the reality of starting 0-3 if they can’t find a way to win. Kansas City hasn’t started this poorly since 2015. Meanwhile, the Giants’ season is already teetering on the brink of disaster.

Online sportsbooks have the Chiefs as road favorites, with sharp money pushing the line toward a touchdown. The spread movement tells the story of a market that believes Kansas City’s talent will finally shine through.

Kickoff is scheduled for 8:20pm ET from MetLife Stadium in East Rutherford, NJ, with NBC providing the broadcast coverage.

Chiefs vs Giants Prediction and Picks

The Chiefs haven’t looked like themselves through two weeks. But this feels like the perfect spot for them to make a statement. Andy Reid is 14-2 straight up after a loss in his last 16 games. Mahomes, Reid, and Travis Kelce have too much pride to let this season slip away before October.

Kansas City’s offensive line has been shaky, allowing pressure on nearly 40% of dropbacks. But they’re facing a Giants defense that can’t stop anyone. New York ranks dead last against the run and has allowed over 30 points in both games.

The sharp money agrees with laying the points. The line moved from -5.5 to -6 on heavy Chiefs action, and some books briefly hit -6.5. When professionals are willing to cross key numbers like 6, it signals strong conviction.

I grabbed Kansas City at -5.5 early in the week, but I’d still play them at -6 if that’s all you can find. This Chiefs vs Giants prediction favors Kansas City’s talent advantage. The talent gap is too wide, and the Chiefs know their season hangs in the balance.

• SNF Pick: Chiefs -5.5 (FanDuel -115), still playable at -6

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KC vs NYG Player Prop to Consider

One prop catching attention is Patrick Mahomes over 28.5 rushing yards. He’s averaging 61.5 yards per game on the ground this season. With the Giants showing zero ability to contain mobile quarterbacks (6.07 YPC), Mahomes should clear this low bar with ease.

KC Chiefs vs NY Giants Betting Odds

The Chiefs opened at -5.5 in the Sunday night football odds, but sharp action quickly pushed them to -6. Some books even touched -6.5 before buyback brought it down. You can still find -5.5 at FanDuel as of late Saturday, however.

The total has climbed from 42.5 to 45, implying that bettors expect offensive fireworks despite both teams’ early struggles.

According to the NFL public betting percentages, 98% of ML handle and 66% of spread money is backing Kansas City. The line movement confirms what the sharps think – this Chiefs team is too good to start 0-3.

Odds as of 12 am on Sept. 21 at NFL betting apps. Ensure you shop multiple books for the best Chiefs vs Giants betting lines.

Kansas City vs Giants Matchup Analysis

What matters more than historical trends is the current state of these teams. The Giants have gone 3-11 ATS in their last 14 games and 1-8 straight up in their last nine home games. Russell Wilson showed flashes against Dallas, throwing for 450 yards. But that game plan of constant deep shots to Nabers won’t work against better defenses.

Kansas City’s defense leads the league with a 44% blitz rate. Wilson has historically struggled against pressure, and the Giants’ offensive line won’t hold up. Steve Spagnuolo will dial up exotic looks that confuse Wilson and force him into mistakes.

The historical trends look concerning for Chiefs backers. Kansas City is 0-7 straight up in their last seven road games against the Giants. They’re also 1-9 ATS in their last 10 meetings overall. But those games date back years, with different rosters and coaching staffs.

Chiefs Recent ATS Struggles

Chiefs vs Giants Injury Report

The injury list remains manageable for both teams, and these injury updates factor into our Chiefs vs Giants picks. Darius Slayton is cleared to play after groin and calf concerns limited him in practice all week. His availability keeps Russell Wilson’s downfield options intact and takes some pressure off rookie Malik Nabers.

For Kansas City, Nazeeh Johnson was placed on injured reserve, eliminating any questions about his status. Charles Omenihu remains questionable with the knee injury that’s bothered him since training camp. Neither is a starter, but their absence would thin out the defensive rotation.

The bigger concern for New York is their defensive front. They’re allowing a league-worst 177.5 rushing yards per game. That’s a problem against any team, but especially one with Patrick Mahomes, who leads all quarterbacks in rushing yards this season.

The Chiefs need this win desperately. Expect them to empty the playbook and dominate a Giants team that looks destined for the number one pick. I’m taking the Chiefs to cover and Mahomes 30+ rushing yards as my Chiefs vs Giants predictions and picks for Sunday Night Football.