- The San Francisco 49ers return from last weekend’s bye as 4-point favorites in a Sunday Night Football clash with the Indianapolis Colts
- SNF Betting Record: 0-0 ML; 2-3 ATS; 4-1 Totals; + 1.6 units
- Read on for all the odds and trends ahead of Sunday night’s Week 7 matchup at Levi’s Stadium
The San Francisco 49ers will be looking to put the brakes on a three-game straight up losing streak that has bounced them from the NFC playoff picture when they play host to the Indianapolis Colts on Sunday Night Football as 4-point home favorites.
The 49ers should be well rested after enjoying a bye last weekend, while the Colts travel to the Bay Area aiming to build on last weekend’s 31-3 rout of the hapless Houston Texans.
Colts vs 49ers Odds
|Indianapolis Colts||+4 (-110)||+165||O 42.5 (-115)|
|San Francisco 49ers||-4 (-110)||-195||U 42.5 (-105)|
*Odds taken at DraftKings on October 23, 2021.
Start time of Sunday night’s contest at Levi’s Stadium is set for 8:20pm ET. Heavy rain is forecast throughout the day in the Santa Clara area with temperatures expected to dip into the low- to mid-60s Fahrenheit by game time.
Sunday night’s contest marks the first meeting between these two teams since 2017. The Colts have dominated in recent matchups, winning outright in each of their past clashes, including a crushing 27-7 victory as 10.5-point underdogs in their last visit to San Francisco in 2013.
While Indianapolis has averaged a respectable 24.75 points per game during their current win streak versus the Niners, San Francisco has struggled to generate offense, tallying fewer than 12 points per game. That has generated a steady 3-1 run for the UNDER in totals betting during that stretch.
— John Perrotto (@JPerrotto) October 18, 2021
Those trends are reflected on this week’s line movement, with the Colts making steady gains since opening as 5.5-point underdogs. The total has also seen movement since opening at 44.5, dipping to its current position at 42.5, with the OVER slightly favored.
Niners Search for End to Home Losing Streak
After being idle last week, the 49ers resume the search for their first win on home turf in almost a year. San Francisco has lost outright in each of their past six home dates, and nine of 10 since the start of the 2020 NFL season.
That run includes a trio of defeats by double-digit margins, and seven losses while pegged as betting favorites. However, the Niners have managed to keep things close in their past three home contests, which were each settled by a single score.
— San Francisco 49ers (@49ers) October 22, 2021
After being sidelined for the past three weeks, Jimmy Garoppolo is expected to return to action on Sunday night. The Niners pivot racked up 925 passing yards and five scoring passes against two picks in four appearances before being sidelined by a calf injury.
Garoppolo will also be facing the Colts for the first time in his career, but enjoys plenty of primetime experience, leading the 49ers to wins in seven of his previous 10 starts under the lights while tossing for 16 total TDs during that stretch. With Jimmy G returning to action, rookie passer Trey Lance will be unavailable as he deals with an ankle injury.
He is joined in the clinic with defensive tackles Javon Kinlaw and Maurice Hurst, who will also miss Sunday night’s contest, while left tackle Trent Williams remains doubtful due to elbow and ankle injuries.
Homecoming for Buckner
Sunday night will mark a homecoming of sorts for DeForest Buckner. The star defensive tackle was dealt to Indianapolis in the wake of the 49ers’ march to Super Bowl 54, and has emerged as a cornerstone of the Colts defense, racking up 28 tackles and two sacks through six outings. However, injuries have also emerged as a concern for Indianapolis as they seek to record just their second win in six overall road outings.
— OurSF49ers (@OurSf49ers_) October 20, 2021
The Colts defense suffered a huge blow in practice this week, when safety Julian Blackmon suffered a season-ending Achilles tear. It is also looking increasingly likely that Colts’ pivot Carson Wentz will have to make do without TY Hilton, who is battling a quad injury.
The Indianapolis receiving corps was already smarting from the loss of Parris Campbell. However, Jonathan Taylor has been picking up the slack in the backfield, scampering for over 100 yards per game and four scores over the past three weeks. Taylor offers solid value as a -115 bet to top 65.5 rushing yards on Sunday against a Niners’ rush defense that has allowed over 114 rushing yards per game and 10 scoring runs over their past eight outings.
The Picks: Colts +4 (-110) – 1 unit