Eagles vs Bills Picks, Prediction, Betting Lines & Playoff Implications (Week 17)

• We have a potential Super Bowl preview in Week 17
• The Eagles look to win their fourth straight against Buffalo
• Keep reading for my Eagles vs Bills picks and predictions for Dec. 28.

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The Philadelphia Eagles (10-5, 5-3 road) trek north to face the Buffalo Bills (11-4, 6-1 home) for a battle between two playoff mainstays. Both teams have clinched playoff spots, but they have loftier goals, as evidenced by their positioning in the current Super Bowl odds.

Highmark Stadium will play host to this cross-conference battle at 4:25 pm ET. FOX will carry the broadcast.

I have selected my four favorite Eagles vs Bills picks. As the season winds down, I have honed in on one game bet and three player props.

PHI Eagles vs BUF Bills Picks & Predictions

• PHI Eagles vs BUF Bills Pick #1: Bills -2.5 (-107, BetRivers)

I am backing the red-hot Bills to win their fifth straight game. They have not lost since Thursday night of Week 12. Otherwise, the Bills have been a machine, scoring 26, 39, 35, and 23 points in those wins. They have also had back-to-back games without a turnover, returning to 2024 form.

The Eagles are a 10-win team, but they have only two wins against teams currently in the playoffs: the Rams and Packers. Neither one of those wins were particularly convincing as the Eagles needed to block a last-second field goal to beat the Rams, and the offense scored only 10 points against the Packers. Against other current playoff teams, the Eagles lost in disappointing fashion to the Broncos and Chargers. Philadelphia was also bludgeoned by the Bears on Black Friday.

• PHI Eagles vs BUF Bills Pick #2: Josh Allen Anytime Touchdown (+140, FanDuel)

Allen has stuffed the statsheet with 12 rushing touchdowns this season, this third season in a row with at least 12. Last time he faced the Eagles, Allen scored two touchdowns on the ground. Allen has rushed for a touchdown in seven games this season. He has four games with two including a three-touchdown game against the Bucs.

Alternatively, you could bet Allen to have over 1.5 passing touchdowns, also a plus-money wager. Allen has multiple total touchdowns in 12 games this season. He has multiple passing touchdowns nine times including four games with three touchdowns.

𝗗𝗜𝗗 𝗬𝗢𝗨 𝗞𝗡𝗢𝗪?: The #Eagles are the ONLY team Josh Allen hasn’t beat besides the #Bills?

Does he win today? 🦬#BuiltInBuffalo | #GoBills | #BillsMafia pic.twitter.com/smlYqhEUFv

— Built in Buffalo (@BuiltInBuffalo_) December 28, 2025

The Eagles have allowed four touchdowns to quarterbacks this season. Patrick Mahomes scored one in Week 2; Jaxson Dart added one in both Giants-Eagles games, and Dak Prescott tied the most recent Cowboys-Eagles game with a rushing touchdown.

• PHI Eagles vs BUF Bills Pick #3: A.J. Brown Over 59.5 Receiving Yards (-137, Sleeper)

Brown needs 65 yards to reach 1,000 yards for the sixth time in seven NFL seasons. He has cleared 59.5 yards in seven games this season, posting at least 80 yards in all seven games. Brown is a boom-or-bust option, so it could be worth taking a ladder up to 100 yards. Brown has five games this season with 100 receiving yards.

one thing about aj brown is he’s going to cook the commanders pic.twitter.com/zOPURn9KRu

— amira (@amirawithluv) December 20, 2025

As good as the Bills are, they are not blessed with stellar cornerbacks. Christian Benford has gone in the wrong direction after a breakout 2024 season, and Tre’Davious White is about to turn 31. Brown has at least 20 pounds on both Benford and White, so any one-on-one matchups will be a prime spot for “Swole Batman” to get his yards.

For what it’s worth, Brown has been on the injury report this week after getting his wisdom teeth taken out. He has been cleared for Sunday, though.

• PHI Eagles vs BUF Bills Pick #4: Michael Badgley Over 2.5 Extra Points Made (+120, BetMGM)

Last week in his Bills debut, Badgley hit two of three extra points. That said, this is more of a bet on the Buffalo offense. Buffalo has 55 touchdowns on the season, averaging 3.67 per game. Buffalo kickers have made at least three extra points in nine of 15 games this season. In three other games, the Bills scored at least three touchdowns.

The Eagles have only allowed 29 touchdowns this season, a shade under two per game. However, the Eagles have allowed three or more touchdowns (with accompanying extra points) in three of their five losses. In a game I expect the Eagles to lose, Buffalo should score at least three touchdowns.

Eagles vs Bills Betting Lines

The Bills are narrow home favorites with the total set between 44 and 44.5 in the current NFL odds. Over bettors should take the over 44 line offered by BetMGM (-110 odds). Under bettors should take under 44.5 courtesy of bet365 (-110 odds).

For those looking to back the Bills, take Buffalo -1.5 on the spread at BetRivers (-108 odds) or -124 on the moneyline, also at BetRivers. For Philadelphia bettors, take the Eagles +2.5 on the spread at FanDuel (-110 odds) or +120 on the moneyline, also at FanDuel.

PHI vs BUF: Last Five H2H Matchups

In a matchup that dates back to 1973, the Eagles hold the lifetime edge in the series 9-6. Both teams have had stretches of dominance with the Eagles winning all four games between 1981 and 1987 while the Bills won the next four between 1990 and 1999. Since 2000, the Eagles have won five of six matchups, including the last three.

Last time these teams squared off, the Eagles won a back-and-forth affair, overcoming a double-digit deficit in three minutes before winning with a walk-off touchdown in overtime. Jalen Hurts had 265 yards and five touchdowns, including the walk-off. Josh Allen had 420 total yards with four touchdowns, leading the game in rushing yards.

Eagles vs Bills Playoff Implications

What’s at Stake for Philadelphia

The Eagles are locked into a home Wild Card game in the NFL playoff bracket by virtue of clinching the NFC East last week and being unable to catch the No. 1 seed. As of Sunday morning, the Eagles have a 12% chance to get the No. 2 seed, an 87% chance to get the No. 3 seed, and a 1% chance to get the No. 4 seed.

With a win, the Eagles would have a 26% chance at the No. 2 seed, drawing a rematch with the Packers from last season’s playoff run. With a loss, the Eagles would have a 99% chance to be the No. 3 seed, a fate that would be secured if the Seahawks beat the Panthers.

What’s at Stake for Buffalo

Buffalo has clinched a playoff spot, but the Bills can move as high as the No. 1 seed. Buffalo can be any seed besides the No. 4 seed. For now, the Bills have a 3% chance at the No.1 seed and a 17% chance at winning the division.

With a win, the Bills would become the odds-on favorite to be the No. 5 seed, but they would have a 31% chance at winning the AFC East. With a loss, Buffalo would be in danger in falling to the No. 7 seed, and the division would be lost if the Patriots beat the Jets.

All playoff percentages are from the Athletic’s playoff predictor.