Early 49ers vs Seahawks Prediction & Expert Picks (Divisional Round)

• Seattle went 1-1 vs San Francisco in the regular season, each winning on the road
• Neither team topped 17 points in either game
• Seattle opens as a consensus 7.5-point home favorite

On Jan. 3, San Francisco hosted Seattle with almost everything at stake: The winner would clinch the NFC West title and first-round bye in the playoffs.

Seattle won 13-3, sending San Francisco into the Wild Card round, across the country, to face the defending Super Bowl champion Philadelphia Eagles. No worries. The 49ers regrouped and rallied late to eliminate the Eagles and advance to the Divisional Round.

Waiting for them? The NFC West champion Seattle Seahawks.

These rivals split two regular-season matchups this season, each winning on the road.

Round 3 is Saturday, January 17 in Seattle. The starting time is TBD. The Seahawks are 7.5-point favorites on January 12. The winner advances to the NFC Championship.

Our comprehensive breakdown covers everything from detailed odds analysis and injury reports to key betting trends and expert predictions for the spread, total, and top player props.

49ers vs Seahawks Expert Picks

The Seattle Seahawks enter as substantial home favorites, the statistical evidence builds a compelling case for the underdog. The market implies a 78.86% win probability for Seattle.

The 49ers, despite battling a -2 turnover differential in their Playoff opener at Philadelphia, showcased impressive efficiency metrics that translate directly to covering spreads in hostile environments.

• Third-Down Conversions: 54.5% (6-for-11)
• Red Zone Touchdown Rate: 66.7% (2-for-3)
• Points: 23
• Total Yards: 361 yards

This ability to sustain drives and capitalize on scoring opportunities becomes crucial for road underdogs facing significant point spreads. While ball security remains a concern, their third-down success rate indicates an offense capable of controlling the clock and responding under pressure. With a clean injury report, the 49ers deploy their complete offensive arsenal, anchored by do-it-all weapon Christian McCaffrey.

Given the substantial point cushion and San Francisco’s proven offensive rhythm against the complete unknown of Seattle’s 2025 season debut, taking the points represents the logical betting value.

Best Spread Bet: San Francisco 49ers +7.5 (-110) at Bet365

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Game Total: Under 45.5 (-110) at BetMGM

The logic aligns with our primary handicap. The teams combined to score 30 points in Week 1 and just 16 to close the regular reason. While it’s reasonable to expect more points, familiarity could keep the winning team’s score in the mid-20s.

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San Francisco 49ers vs Seattle Seahawks Odds

Odds as of January 12, 2026 from consensus odds.

The betting market establishes the Seattle Seahawks as substantial home favorites in this Division Round battle. The -373 moneyline indicates strong market belief in an outright victory, while the San Francisco 49ers sit as considerable underdogs at +293. The point spread holds firm at 7.5 points, requiring Seattle to win by more than a touchdown to cover. The game total lands at 45.5 points, with slight value placed on the Over (-112).

After removing the vig, consensus odds suggest a 75.6% implied probability for a Seahawks victory compared to 24.4% for the visiting 49ers.

49ers vs Seahawks Injury Report

According to the January 12, 2026 update, both rosters maintain full strength, representing a major factor. All key contributors are expected to be active and available.

Team Statistics Comparison: 49ers vs Seahawks

Who has the edge? Here’s a look at several key 2025 regular-season statistics.