Jacksonville Jaguars vs Cincinnati Bengals Predictions, Prop Picks & Closing Odds

• The Cincinnati Bengals host the Jacksonville Jaguars in Week 2 with both teams looking to improve to 2-0
• After getting shredded by the Brows, the Cincinnati O-line gets another stiff test from Josh Hines-Allen and Travon Walker
• See the closing Jaguars vs Bengals odds plus my JAX vs CIN predictions and player props to bet

Two AFC contenders aiming to build on 1-0 starts clash in Week 2 as Joe Burrow and the Cincinnati Bengals (1-0, 0-0 home, 0-1 ATS, 0-1 O/U) welcome Trevor Lawrence and the Jacksonville Jaguars (1-0, 0-0 away, 1-0 ATS, 0-1 O/U) to the Queen City at 1:00 pm ET on Sunday, Sep. 14.

While both teams secured victories in the opening week, they did so in starkly different fashions. The Bengals eked out a 17-16 win over the Browns despite their high-powered offense looking out of sync, while the Jaguars bulldozed the Panthers 26-10 behind a dominant ground game.

This matchup presents a classic strength-on-weakness scenario: can Cincinnati’s beleaguered offensive line protect Burrow from a Jaguars front that is built to hunt quarterbacks? Below, I’ll dissect the betting odds, analyze critical matchups, and set out my Jaguars/Bengals prediction and best player prop to target.

Jump to: Odds | Player Props | Prediction & Picks

Jaguars vs Bengals Odds

As of 1:15 am ET on Sunday morning, the Bengals were -174 favorites (or shorter) with FanDuel offering the best price. The Jaguars were as long as +158 on the moneyline. All books had the spread a CIN -3.5 with only slight variations in price. The game total still showed a half-point range with bet365 offering the best over line (49.0 at -110) and DraftKings offering the best under line (49.5 at -115). The interactive table, above, will update in real time to display the best available odds.

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Trends suggest the Jaguars perform well in this spot, boasting a 7-3 ATS record in their last ten games as an underdog.

Jacksonville vs Cincinnati Odds Movement

This spread and moneyline have hardly moved over the course of the week. The opening NFL Week 2 odds established Cincinnati as a -180 moneyline favorite and -3.5 (-110) ATS, which are almost identical to the current odds. The total, however, has been bet down by as much as a point-and-a-half after opening at 50.5.

The total has dropped from 50.5 to 49.0 at some books, suggesting a slight lean towards the defenses or a run-heavy game script from Jacksonville that could bleed the clock.

JAX vs CIN Key Matchups to Watch

Jaguars Run Game vs Bengals Rush Defense

This is a marquee matchup. The Jaguars unleashed a punishing ground-and-pound attack in Week 1, racking up 200 yards at an explosive 6.3 yards per carry, led by Travis Etienne Jr. They will look to establish that dominance again to control the clock and set up play-action. On the other side, the Bengals’ run defense was stout, yielding a mere 49 rushing yards at 2.0 yards per carry. This battle of strength versus strength could determine the flow of the game.

Jaguars Pass Rush vs Bengals O-Line

This is the game within the game. The Bengals’ offensive line was a liability in Week 1, consistently losing battles at the point of attack. That’s a frightening prospect against a Jaguars front headlined by Josh Hines-Allen and Travon Walker, who can wreck a game plan from the edge.

The Jaguars’ defensive front looked ferocious in Week 1. Cincinnati must find schematic answers – e.g. quicker passes and screens – to keep Burrow upright. If they can’t, the Jaguars’ pass rush could single-handedly decide this contest.

JAX vs CIN Player Props

NFL player props as of September 14 at MGM.

The most glaring value on the board is Travis Etienne Jr’s rushing yards prop of 54.5. After a week where he looked explosive (143 yards on 16 carries) and the team rushed for exactly two bills, this number feels far too low, even against a solid Cincinnati run defense.

Joe Burrow’s passing-yards prop is ambitious given the offensive line’s struggles and the strength of Jacksonville’s pass rush. The under at 276.5 yards is tempting, as the Bengals may lean on a quick, short passing game to mitigate pressure.

Trevor Lawrence’s line of 241.5 yards is more achievable, but if the Jaguars establish the run early, they may not need him to air it out, putting the under in play for him as well.

Ja’Marr Chase’s line of 83.5 receiving yards is a solid bounce-back spot for a superstar receiver playing at home.

Jacksonville Jaguars vs Cincinnati Bengals Prediction & Picks

The outcome of this game will be decided in the trenches. While the Bengals have the star power at quarterback and receiver to light up any opponent, their offensive line’s performance in Week 1 raises major red flags. The Jaguars are built to exploit that exact weakness with a relentless pass rush led by Josh Allen and Travon Walker. If Cincinnati cannot protect Burrow, their offense will sputter just as it did last week, regardless of the talent on the perimeter. The Jaguars’ offensive gameplan should provide the perfect counterbalance: a heavy dose of Travis Etienne Jr to control the clock, wear down the Bengals’ defense, and keep their own defense fresh to attack Burrow.

Several betting trends support the road underdog. The Jaguars are an impressive 7-3 ATS in their last ten games as an underdog and 5-2 ATS in their last seven when getting fewer than seven points. Conversely, the Bengals have struggled against quality opponents, going just 1-3 ATS in their last four games against teams with a winning record.

While Cincinnati is tough at home, the schematic advantage for Jacksonville is too significant to ignore. The Jaguars have the blueprint to not only cover but win this game outright.

JAX vs CIN Picks:

• Jaguars +3.5 (-115) at bet365
• Under 49.5 (-115) at DraftKings
• Travis Etienne Jr over 54.5 rushing yards (-115) at BetMGM