NFL ATS Picks & O/U Bets for Week 11 – Top A.I. Predictions

Published: November 10, 2025 at 2:07 pm EST

Baltimore Ravens wide receiver DeAndre Hopkins catching a TD pass against the Cleveland Browns — Sep 14, 2025; Baltimore, Maryland, USA; Baltimore Ravens wide receiver DeAndre Hopkins (10) makes a catch for a touchdown during the fourth quarter at M&T Bank Stadium. Mandatory Credit: Mitch Stringer-Imagn Images

The NFL Week 11 odds are out for all 15 games
I have asked our internal A.I. to provide its best NFL ATS picks and O/U predictions for each Week 11 matchup
See our A.I.’s NFL ATS picks and O/U predictions for all 15 games in Week 11

The Week 11 NFL slate is undoubtedly the best of the season so far, featuring no fewer than four games between legitimate contenders in the Super Bowl odds.

Though Week 10 isn’t quite in the books just yet – a marquee matchup between the Eagles and Packers awaits on MNF and readers can tail a host of bets on SBD, like my Eagles vs Packers player props and John Hyslop’s Eagles vs Packers SGP – the Week 11 odds are out for all 15 games, and I have already asked our internal A.I. to generate its ATS and O/U prediction for each matchup.

The table below lists the A.I. ATS picks and O/U best bets for all 15 games, plus the sportsbook currently offering the best price. Under the table, find one-click options to tail each bet.

A.I. NFL ATS & O/U Picks (Week 11)

Game	ATS Pick	O/U Pick
NY Jets vs NE Patriots	NE -11.5 (-107 at Caesars)	O 43.0 (-113 at BetRivers)
WSH Commanders vs MIA Dolphins	WSH +2.5 (+101 at Underdog)	U 47.5 (-110 at SI)
LA Chargers vs JAX Jaguars	LAC -2.5 (-117 at Caesars)	U 44.5 (-110 at bet365)
TB Buccaneers vs BUF Bills	BUF -5.5 (-108 at Caesars)	O 49.0 (-110 at BetRivers)
CHI Bears vs MIN Vikings	CHI +3.5 (-129 at Underdog)	O 47.5 (-120 at FanDuel)
GB Packers vs NY Giants	GB -7.5 (-120 at FanDuel)	U 44.5 (-109 at Caesars)
HOU Texans vs TEN Titans	HOU -7.0 (-110 at bet365)	U 39.5 (-110 at BetMGM)
CAR Panthers vs ATL Falcons	ATL -3.5 (-110 at DraftKings)	U 42.5 (+100 at ESPN)
CIN Bengals vs PIT Steelers	CIN +6.0 (-110 at at BetMGM)	U 49.5 (-115 at FanDuel)
SF 49ers vs ARI Cardinals	ARI +3.0 (-114 at Caesars)	O 48.0 (-110 at BetMGM)
SEA Seahawks vs LA Rams	LAR -2.5 (-110 at bet365)	O 48.0 (-112 at BetRivers)
KC Chiefs vs DEN Broncos	KC -3.5 (-110 at FanDuel)	O 44.5 (-115 at DraftKings)
BAL Ravens vs CLE Browns	CLE +9.0 (-110 at SI)	U 41.5 (-105 at FanDuel)
DET Lions vs PHI Eagles	DET +2.0 (-114 at BetRivers)	O 48.5 (-110 at FanDuel)
DAL Cowboys vs LV Raiders	DAL -3.0 (-120 at bet365)	U 50.5 (-110 at Caesars)

The A.I. is coming off a solid 9-4 ATS performance in Week 10 but it’s still an ugly 61-74 ATS on the season.

It went 6-7 O/U in Week 10 (ahead of MNF) and is a comically bad 58-77 O/U during the 2025 regular season.

Odds and best prices as of 2:03 pm ET, November 10th. Bookmark SBD’s BetMGM Missouri page to see the latest offers prior to launch in December.

Jets vs Patriots Picks

Commanders vs Dolphins Picks

Chargers vs Jaguars Picks

Buccaneers vs Bills Picks

Bears vs Vikings Picks

Packers vs Giants Picks

Texans vs Titans Picks

Panthers vs Falcons Picks

Bengals vs Steelers Picks

49ers vs Cardinals Picks

Seahawks vs Rams Picks

Chiefs vs Broncos Picks

Ravens vs Browns Picks

Lions vs Eagles Picks

Cowboys vs Raiders Picks

Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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