Opening 49ers vs Seahawks Odds for Divisional Round

• The San Francisco 49ers will visit the Seattle Seahawks in the 2026 NFL Divisional Round
• The 49ers and Seahawks split their two regular-season meetings
• See the opening 49ers vs Seahawks odds for the Divisional playoffs

A fierce NFC West rivalry will be renewed in the 2026 NFL Divisional Round as the Seattle Seahawks (14-3, 6-2 home) get set to host the San Francisco 49ers (13-5, 8-2 away) on either Saturday, January 17th, or Sunday, January 18th.

The 49ers advanced with a narrow 23-19 victory over the Philadelphia Eagles (covering as six-point underdogs) while the Seahawks got a bye as the NFC’s #1 seed.

The opening 49ers vs Seahawks odds for the Divisional Round heavily favor Seattle holding serve at home.

Opening 49ers vs Seahawks Odds (Divisional Round)

The point spread has opened at SEA -6.5 with -110 odds each way. The game total is 47.5, again with -110 odds both ways. On the moneyline, Seattle is a -270 favorite with San Francisco +220 to pull off a second road upset in as many weeks.

Odds as of 7:51 pm ET at DraftKings. Claim the top NFL betting promos for the Divisional Round.

The teams split their two regular-season meetings, with the Niners winning 17-13 all the way back in Week 1, and the Seahawks taking a 13-3 decision in the Week 18 finale.

A head-to-head statistical comparison shows the Seahawks with an advantage in almost every category.

SF 49ers vs SEA Seahawks H2H Statistical Comparison

The Seahawks average nearly a field goal more per game while allowing 4.6 fewer points. They also surrender 55 fewer yards per game, while equalling the Niners in offensive yardage.

Bookmark SBD’s NFL odds page to see up-to-the-minute lines for every 2026 playoff game.

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