Skip to content

Opening NFL Week 16 Odds – Points Spread, Moneyline, Total for All Games

Sascha Paruk

By Sascha Paruk in NFL News

Published:


Seattle Seahawks quarterback Sam Darnold throwing on the run against the LA Rams
Nov 16, 2025; Inglewood, California, USA; Seattle Seahawks quarterback Sam Darnold (14) is pressured by Los Angeles Rams linebacker Jared Verse (8) at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images
  • The NFL Week 16 odds have been posted
  • Two marquee matchups will take place on Saturday, Dec. 20
  • See the opening NFL Week 16 odds, including spread, moneyline, and total for all 16 games

The NFL Week 16 odds have been posted for all games on the slate. The antepenultimate week of the season features some massive games in both the AFC and NFC playoff races. The table below sets out the opening spread, moneyline, and total for all 16 games on the docket.

With the NCAAF entering bowl season, the NFL will takeover Saturday with a pair of divisional matchups: Eagles vs Commanders (5:00 pm ET) and Packers vs Bears (8:20 pm ET).

NFL Week 16 Odds

TeamSpreadMoneylineTotal
LA Rams+1.0 (-115)-110O 46.5 (-110)
SEA Seahawks-1.0 (-105)-110U 46.5 (-110)
TeamSpreadMoneylineTotal
PHI Eagles-5.0 (-110)-258O 45.5 (-105)
WSH Commanders+5.0 (-110)+210U 45.5 (-115)
TeamSpreadMoneylineTotal
GB Packers-3.0 (-110)-166O 46.5 (-110)
CHI Bears+3.0 (-110)+140U 46.5 (-110)
TeamSpreadMoneylineTotal
BUF Bills-9.5 (-108)-485O 41.5 (-110)
CLE Browns+9.5 (-112)+370U 41.5 (-110)
TeamSpreadMoneylineTotal
LA Chargers+2.5 (-110)+114O 48.5 (-110)
DAL Cowboys-2.5 (-110)-135U 48.5 (-110)
TeamSpreadMoneylineTotal
NY Jets+3.5 (-110)+154O 39.5 (-110)
NO Saints-3.5 (-110)-185U 39.5 (-110)
TeamSpreadMoneylineTotal
TB Buccaneers-1.5 (-115)-125O 44.5 (-110)
CAR Panthers+1.5 (-105)+105U 44.5 (-110)
TeamSpreadMoneylineTotal
MIN Vikings-1.5 (-108)-118O 42.5 (-118)
NY Giants+1.5 (-112)-102U 42.5 (-102)
TeamSpreadMoneylineTotal
KC Chiefs-10.5 (-110)-675O 40.5 (-115)
TEN Titans+10.5 (-110)+490U 40.5 (-105)
TeamSpreadMoneylineTotal
CIN Bengals-1.5 (-102)-115O 50.5 (-108)
MIA Dolphins+1.5 (-118)-105U 50.5 (-112)
TeamSpreadMoneylineTotal
JAX Jaguars+2.5 (-102)+130O 44.5 (-110)
DEN Broncos-2.5 (-118)-155U 44.5 (-110)
TeamSpreadMoneylineTotal
ATL Falcons+1.5 (-120)-108O 45.5 (-115)
ARI Cardinals-1.5 (-100)-112U 45.5 (-105)
TeamSpreadMoneylineTotal
LV Raiders+11.5 (-108)+525O 37.5 (-110)
HOU Texans-11.5 (-112)-750U 37.5 (-110)
TeamSpreadMoneylineTotal
PIT Steelers+6.5 (-105)+240O 49.5 (-110)
DET Lions-6.5 (-115)-300U 49.5 (-110)
TeamSpreadMoneylineTotal
NE Patriots+2.5 (-115)+110O 47.5 (-110)
BAL Ravens-2.5 (-105)-130U 47.5 (-110)
TeamSpreadMoneylineTotal
SF 49ers-6.5 (-120)-340O 45.5 (-110)
IND Colts+6.5 (-100)+270U 45.5 (-110)

The biggest spread of the week comes from the Raiders/Texans game in Houston, where the Texans (winners of five straight) have opened as 11.5-point home chalk over the Raiders (losers of seven in a row).

The Chiefs/Titans mismatch in Tennessee also has a double-digit spread, with Kansas City opening as an 11.5-point road favorite.

The highest total is 50.5 in Bengals/Dolphins, despite Cincinnati currently getting shutout at home in Week 15 by the Ravens (17-0 late in the 4th quarter).

The lowest total is a meager 37.5 points in Raiders/Texans. It’s a serious rarity that the highest spread and lowest total come from the same game.

Odds as of 3:30 pm ET at bet365, theScore Bet, and DraftKings. Bookmark SBD’s NFL odds page to see the latest lines for every game.

Opening Rams vs Seahawks Odds

In arguably the biggest game of the week, Rams vs Seahawks has opened as a pick’em, with both teams listed at -110 on the moneyline.

The total has opened at 46.5 points, a number these teams stayed well under in their Week 11 meeting – a 21-19 Rams victory at home, which included a long missed field goal by the Seahawks on the final play of the game.

If both teams hold serve in Week 15, the winner of this game will hold top seed (and lone bye) in the NFC with just two games to play.

Opening Packers vs Bears Odds

The other game with a strong argument for the “game of the week” mantle is Packers vs Bears in Chicago.

Green Bay has opened as a field-goal favorite on the road, with the total at 46.5.

Green Bay held on for a 28-21 home win when they met on Thanksgiving.

  • BETMGM SPORTSBOOK

    USE CODE SBD1500 & GET $1,500 BACK IN BONUS BETS

  • BET365 SPORTSBOOK

    BET $5 & GET $150 IN BONUS BETS WITH CODE DIME365

  • FANATICS SPORTSBOOK

    BET & GET UP TO $2,000 IN FANCASH

  • DRAFTKINGS SPORTSBOOK

    BET $5 & GET $200 IN BONUS BETS IF YOUR BET WINS

  • FANDUEL SPORTSBOOK

    BET $5 & GET $150 IF YOUR BET WINS

  • CAESARS SPORTSBOOK

    USE CODE SBD20X & BET $1 TO DOUBLE THE WINNINGS ON YOUR FIRST 20 WAGERS!

  • THESCORE BET SPORTSBOOK

    USE CODE DIME TO UNLOCK BET $10, GET $100 BONUS

  • DRAFTKINGS SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $200 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Token expires 1/11/26. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 1/4/26 at 11:59 PM ET. Sponsored by DK.

  • BET365 SPORTSBOOK T&Cs: Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply. GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ only (18+ KY).

  • BETMGM SPORTSBOOK T&Cs: Gambling problem? Call 1-800-GAMBLER (Available in the US), Call 877-8-HOPENY or text HOPENY (467369) (NY), Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

NFL NBA MLB NHL NCAAF NCAAB Politics Tennis MMA Sportsbooks Gambling

Recommended Reading